Clinical outcome and prognostic factors for central neurocytoma, a study of 14 cases

Abstract

Background: Since they’re rare, the intraventricular neoplasms “central neurocytoma” best management got diverse, and mystifying. Aim of the work: to assess outcome for patients with central neurocytoma and value of specific factors like tumor size, surgical resection extent, atypia, and concomitant other modality of treatments by radiotherapy in their survival. Patients & methods: 14 patients (8 males, 6 females) were managed surgically between 2012 and 2016. They were assessed clinically, radiologically and their outcome in relation to selected factors. Results: Median age at diagnosis was 28.3 years in average (range 16–58). Median follow-up was 32.2 months.we lost 2 cases to follow-up in post-operative period. Six patients had recurrent of neurocytoma tumours.Five patients (35.7 %) obtained gross total resections (GTR) while 9 patients (64.2 %) had subtotal resections (STR). Two STR patients (14.2 %) received dose of radiation post operatively that significantly enhanced overall PFS (p =0.047). our series data propose that radiation therapy following (STR) usually increase (PFS). Two patients proved to have atypical neurocytoma by pathological reports died at 2.3 and 10.2 months after the microsurgical procedures. MIB-1 tagging index higher than 4 % is an indicator for poor outcome. We used Kaplan–Meier beside Cox proportional hazards methods in determining the Progression-free survival (PFS) in our study. Conclusion: the extent of surgical resection may improve the neurological condition but not the survival, Atypia was the most important factor determine the recurrence & survival while radiotherapy improve the survival quietly.

Long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy – Case report from a Tertiary Kenyan Cancer Hospital

“…[ 9 ] Gross resection has better outcome than a subtotal resection. [ 18 ] Extent of resection is considered as the most important prognostic factor in the central neurocytoma. [ 27 ] Recurrence rate of central neurocytoma, even after complete resection has been shown in long-term follow- up studies.…”