Clinical outcome and risk factors of neonatal sepsis among neonates in Felege Hiwot referral Hospital, Bahir Dar, Amhara Regional State, North West Ethiopia 2016: a retrospective chart review

Tewabe, Tilahun; Mohammed, S.; Tilahun, Yibeltal; Melaku, Birhanie; Fenta, Mequanint; Dagnaw, Tsigiereda; Belachew, Amare; Molla, Ashagre; Belete, Habte

doi:10.1186/s13104-017-2573-1

Cited by 82 publications

(72 citation statements)

References 25 publications

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“…The study conducted in Ethiopia indicated that around 15% of meningitis clients might end up with unwanted outs comes of which death is one of it. This finding is relatively lower than the current study result [26]. The difference might be because the study in Bahr Dar, Ethiopia was done for a short period of time that might be associated with difficulties in estimating the exact number within a short time.…”

Section: Fig 1 Organisms Isolated From Csf Cultures Of Patients Of contrasting

confidence: 92%

A Five Years Retrospective Study on Etiology and Clinical Analysis of Meningitis in St. Paul’s Hospital Millennium Medical College Pediatric Ward from 2012-2016

Ayele

Bitew

Temesgen

et al. 2019

IJTDH

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Meningitis is the sever CNS pyogenic infections which primarily affects infants and children. Ethiopia is one of the countries where meningitis is endemic and frequent episodes of meningococcal epidemics are very common in the dry season (December to June). The main purpose of this study was to identify determinants and clinical analysis of meningitis in pediatrics ward admitted to St.Paul’s hospital millennium medical college pediatrics wards from 2012-2016. A retrospective study on etiology and clinical analysis of meningitis was conducted at the pediatric unit. The study population was all pediatric patients admitted with meningitis that were presented in ward during the study period. Those fulfilling the mentioned inclusion criteria were included. The data were collected using a structured format in September /2016. From the study population 95 cases fulfilled the inclusion criteria and 64 & 31 of them were males and females, respectively making a male to female ratio of 2:1. The most significant seasonal variation was observed for N. meningitidis having high incidence in the 2nd quarter (April to June). In the dry season 18 cases were diagnosed using the culture results. Culture findings also revealed that S. pneumonia was one of the commonest causes of bacterial meningitis. The most common symptom was fever with high grade fever (>38oC) recorded in 84 (88.4%) of cases. Most (65.5 %). of clients were recovered from meningitis at the end of the treatment where as death was the second outcome with 17(20.2 %) cases ended up with death. Neurological or other complications were seen in 9(10.7 %) cases.

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Section: Fig 1 Organisms Isolated From Csf Cultures Of Patients Of contrasting

confidence: 92%

A Five Years Retrospective Study on Etiology and Clinical Analysis of Meningitis in St. Paul’s Hospital Millennium Medical College Pediatric Ward from 2012-2016

Ayele

Bitew

Temesgen

et al. 2019

IJTDH

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“…CSF sample collection after prior antimicrobial treatment could obviously contribute to culture negative results. The overall prevalence of bacterial meningitis of the current study was also lower than study conducted in Bahr Dar that reported a prevalence of 69.8% (33). This difference could be due to difference diagnostic method.…”

Section: Discussioncontrasting

confidence: 78%

Bacterial isolates from CSF sample and their antimicrobial resistance patters in among under-five children suspected for meningitis in Dilla University Referral Hospital

Awulachew

Diriba

Awoke

2020

Preprint

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Introduction: Bacterial meningitis is medical emergency that requires immediate medical attention. It is a cause of an estimated 288, 649 deaths worldwide per year, of which 94 883 death occur among Under-five children. Up to 24% of the survivors suffer from long-term sequelae such as epilepsy, mental retardation, or sensorineural deafness especially when the disease is contracted during early childhood.Objective: the aim of this study was to assess bacterial isolates of CSF sample and their antimicrobial resistance patterns among under-five children in Dilla University Referral Hospital. Material and Methods:Hospital based cross-sectional study design was used to collect clinical data and CSF sample from under-five children who was suspected for meningitis. Sediment of CSF sample was inoculated to Blood Agar plate, Chocolate Agar plate and Mackonkey Agar for bacterial isolation and identification. Chemical analysis and cytological analysis was also conducted based on standard operating procedures.Results: From a total of 287 CSF sample cultured, causative bacteria were detected in 38 (13.2%). From culture positive cases the most frequent isolate was Streptococcus pneumoniae 13 (34.2%) followed by Staphylococcus aureas 7 (18.4%), Neisseria meningitidis 6 (16%) and Escherichia coli 6 (16%). Haemophilus influenzae b was isolated in 4 (10.5%) of children with meningitis. The other cause of meningitis was Streptococcus agalactiae which accounted (10.5%). Cryptococcus neoformans have been detected in 4 (1.9%) cases of meningitis. Of all bacterial isolates about 42.1% (16/38) bacterial isolates were multidrug resistant. About 38.5% of S. pneumoniae was multidrug resistance while about 33.3% N. meningitis, 50% of H. influenzae, 57.1% of S. aureas and 40% of E. coli showed multidrug resistance Conclusions: High prevalence of bacterial meningitis and high rate of drug resistance were observed. S. pneumoniae was the leading cause of bacterial meningitis among under-five children.

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“… 46 However, contrasting findings were observed in earlier studies conducted in different parts of the world. 9 44 47 48 49 Early rupture of membrane and prolonged labor increases the chance of ascending microorganisms from the birth canal into the amniotic sac and fetal compromise as well as asphyxia which frequently leads to sepsis in the neonatal period. 50 This finding could serve as justification for prophylactic antibiotic therapy for neonates born to mothers with a history of PROM during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with neonatal sepsis in a tertiary hospital, North West Nigeria

et al. 2020

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Context: Neonatal sepsis is an important cause of morbidity and mortality of newborns, especially in developing countries. Aims: Our study determined the prevalence of neonatal sepsis and its predisposing factors among neonates admitted in Ahmadu Bello University Teaching Hospital (ABUTH). Settings and Design: This was a cross-sectional descriptive study conducted in ABUTH. Subjects and Methods: The data were abstracted from the case notes of neonates admitted from May 2017 to May 2018. A pretested pro forma was used to abstract the data. Statistical Analysis Used: Odds ratios and multivariate logistic regression were used to determine the factors associated with neonatal sepsis among the study population. Results: The prevalence of neonatal sepsis was 37.6%. Escherichia coli was the most commonly isolated organism. Neonates 0–7 days of age were 2.8 times less likely to develop neonatal sepsis than older neonates. Babies born with an Apgar score of <6 within the 1 st min were 2.4 times more likely to develop neonatal sepsis than those whose Apgar score was higher. Neonates of mothers who had urinary tract infection during pregnancy were 2.3 times more likely to have had sepsis and those whose mothers had premature rupture of membranes were 4.6 times more likely. Conclusions: The prevalence of neonatal sepsis was high among the neonates studied. Neonatal and maternal factors were associated with sepsis in the neonates. These findings provide guidelines for the selection of empirical antimicrobial agents in the study site and suggest that a continued periodic evaluation is needed to anticipate the development of neonatal sepsis among neonates admitted.

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Clinical outcome and risk factors of neonatal sepsis among neonates in Felege Hiwot referral Hospital, Bahir Dar, Amhara Regional State, North West Ethiopia 2016: a retrospective chart review

Cited by 82 publications

References 25 publications

A Five Years Retrospective Study on Etiology and Clinical Analysis of Meningitis in St. Paul’s Hospital Millennium Medical College Pediatric Ward from 2012-2016

A Five Years Retrospective Study on Etiology and Clinical Analysis of Meningitis in St. Paul’s Hospital Millennium Medical College Pediatric Ward from 2012-2016

Bacterial isolates from CSF sample and their antimicrobial resistance patters in among under-five children suspected for meningitis in Dilla University Referral Hospital

Prevalence and factors associated with neonatal sepsis in a tertiary hospital, North West Nigeria

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