Clinical outcome in Japanese elderly patients with non-valvular atrial fibrillation taking warfarin: A single-center observational study

Persistence of oral anticoagulants in japanese patients with atrial fibrillation: non-vitamin k antagonist oral anticoagulant versus warfarin

“…This may also mean that the time in the therapeutic range (TTR) in generally higher in Japan than other countries [17,18]. The previous Japanese guideline for pharmacotherapy of AF (JCS of NOAC treatment was the occurrence of adverse events, including bleeding events; this was similar to the findings for the Dresden cohort [8,11,12].…”

Target International Normalized Ratio Values for Preventing Thromboembolic and Hemorrhagic Events in Japanese Patients With Non-Valvular Atrial Fibrillation

“…6 However, the sample size of the combined study was not large enough to determine the optimal INR values for preventing thromboembolic and hemorrhagic events. 6 A recent retrospective study 7 supported the assertion that lower INR values, such as those suggested in the study by Yasaka et al, 6 are optimal for elderly patients with NVAF in Japan. Lower INR values were also effective at preventing thromboembolic events among Chinese patients with AF.…”

“…In addition, they found that an INR ≥2.5 was associated with a trend toward an increased risk of major hemorrhage. 7 Among Chinese patients receiving warfarin, lower INR values were also suggested to be optimal for preventing embolic and bleeding events. In a retrospective study involving the risk of hemorrhagic events was significantly increased at an INR ≥2.0.…”

Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants vs. Warfarin in Japanese Patients With Atrial Fibrillation

“…20 If the target PT-INR was set between 1.6 and 2.6, the TTR in Japanese patients taking warfarin was not low in practice. 14, 21 Indeed, the TTR in elderly patients (≥70 years) in the J-ROCKET AF trial was 74%, and therefore, a lower TTR (especially PT-INR <2.0) in the 3 trials was not necessarily due to poor warfarin control or warfarin adherence but reflected what was recommended in Japanese guidelines. The data from the J-RHYTHM registry indicate that most INR outside the therapeutic range were below the therapeutic range that applied to patients aged <70 years (ie, <2.0), reflecting the tendency of Japanese physicians to favor lower levels of anticoagulation.…”