Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy

Naqi, S. A.; Ashfaq, Ahmed Hassan; Umar, Mumtaz Ahmad; Karmani, Jais Kumar; Arshad, Naveed

doi:10.12669/pjms.37.2.2670

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…It mainly benefits from the enhanced inhibitory effect of montelukast sodium on leukotrienes, which reduces the destructive impact of leukotrienes on the immune system, improves immune capacity, and effectively promotes the rehabilitation of children. 30,31 This result is consistent with similar reports at home and abroad. In this study, we also found that the recovery time of related symptoms in the study group was shorter than that in the control group (P < 0.05), and the difference was prominent.…”

Section: Comparison Of Symptom Recovery Between Both Groupssupporting

confidence: 92%

Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma

Chu

Liang

Chen

2023

Allergol Immunopathol

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Background and aim: Bronchial asthma is a prevalent type of respiratory disease that affects a large proportion of pediatric patients. The purpose of this study is to further investigate the clinical effects of budesonide combined with montelukast sodium in treating bronchial asthma. Methods: Eighty-six children with bronchial asthma were equally divided into study and control groups via randomized double-blind controlled trial. The control group was treated with aerosol inhalation of budesonide combined with placebo, while the study group was treated with budesonide combined with montelukast sodium. Pulmonary function parameters, immunoglobulin, and recovery of related symptoms, along with the adverse reaction rate, were observed and compared between both groups. Results: Before treatment, there was no marked difference in pulmonary function parameters and immunoglobulin indexes between both groups (P > 0.05). All pulmonary function indicators and immunoglobulin indexes in both groups improved following therapy, with the study group outperforming the control group (P < 0.05). The recovery time of related symptoms in the study group was shorter than that in the control group (P < 0.05). The incidence of adverse reactions in both groups was compared, with notable differences (P < 0.05). Conclusion: Budesonide combined with montelukast sodium in the treatment of bronchial asthma has the value of clinical application and promotion.

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Section: Comparison Of Symptom Recovery Between Both Groupssupporting

confidence: 92%

Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma

Chu

Liang

Chen

2023

Allergol Immunopathol

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“…Our study contains seven RCTs 13–19 with 742 included children. Among them, there were 347 males and 395 females.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, seven studies matched our inclusion criteria and were included in the final analysis. [14][15][16][17][18][19][20] The process of our study selection is shown in the PRISMA flow diagram (Figure 1).…”

Section: Literature Searchmentioning

confidence: 99%

“…Among them, there were 347 males and 395 females. Three included studies compared montelukast versus placebo, 16,17,20 another three compared montelukast versus mometasone furoate 15,16,20 and only one study compared montelukast versus mometasone furoate versus no treatment. 18 Five studies assessed snoring and mouth breathing as signs of adenoid hypertrophy improvement.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Efficacy of montelukast for adenoid hypertrophy in paediatrics: A systematic review and meta‐analysis

Alanazi,

Alruwaili,

Alanazy

et al. 2024

Clinical Otolaryngology

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IntroductionLeukotrienes play a significant role in the pathogenesis of adenoid hypertrophy (A.H.). Therefore, we aimed to analyse the role of montelukast, a leukotriene receptor antagonist, alone or in combination with mometasone, a potent local intranasal steroid, for the treatment of A.H.MethodsParticipants were children with A.H. were treated with montelukast alone or montelukast and mometasone furoate. The main outcome measures were effect of montelukast on clinical symptoms of A.H. A literature review was conducted using online search engines, Cochrane Library, PubMed, Web of Science and Scopus, for randomized clinical trials assessing children with A.H. treated with montelukast alone or montelukast and mometasone furoate. Seven randomized clinical trials (RCTs) were included with 742 children.ResultsOur study reveals that montelukast alone or in combination with intranasal mometasone furoate significantly improves clinical symptoms of adenoid hypertrophy such as snoring, sleeping disturbance, mouth breathing and A/N ratio. Montelukast was superior to placebo in decreasing snoring (SMD = −1.00, 95% CI [−1.52, −0.49]), sleep discomfort (SMD = −1.26, 95% CI [−1.60, −0.93]), A/N ratio (MD = −0.11, 95% CI [−0.14, −0.09]) and mouth breathing (SMD = −1.36, 95% CI [−1.70, −1.02]). No difference was detected between montelukast and mometasone versus mometasone alone in snoring (SMD = −0.21, 95%CI [−0.69, 0.27]); however, the combination group was superior to the mometasone alone in mouth breathing (SMD = −0.46, 95% CI [−0.73, −0.19]).ConclusionsThe limitation of studies included a small sample size, with an overall low to medium quality. Thus, further larger, higher‐quality RCTs are recommended to provide more substantial evidence.

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“…[ 8 , 9 ] Therefore, non-surgical treatments are often the first choice of parents. Montelukast [ 19 , 20 ] and intranasal corticosteroids are important treatment options for AH. However, montelukast is associated with potential risks, including hyperactivity, sleep disorders, and depression.…”

Section: Discussionmentioning

confidence: 99%

Effect of oral Xiao-xian decoction combined with acupoint application therapy on pediatric adenoid hypertrophy: A randomized trial

Zhao

Wang

et al. 2023

Medicine

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Background: This study aimed to observe the clinical effects of Xiao-xian decoction combined with acupoint application therapy (AAT) for treating pediatric adenoid hypertrophy (AH). Methods: We randomly divided 93 AH children into 3 groups: AAT alone; Xiao-xian decoction + AAT; control: Montelukast oral therapy. All participants were treated for a month. We used the traditional Chinese medicine syndrome score to evaluate the clinical efficacy and the obstructive sleep apnea-18 scale to evaluate the quality of life. Results: The major symptoms (nasal congestion, open mouth breathing, snoring, and tongue image) and secondary symptoms of patients treated with Xiao-xian decoction + AAT significantly improved compared to before treatment. The pairwise comparison between groups showed that snoring, tongue, secondary symptoms, and total effective rate of the combined treatment group were better than the control and AAT alone. Additionally, the open-mouth breathing, quality of life, and recurrence rate did not differ after treatment. Conclusion: Oral Xiao-xian decoction combined with AAT significantly improved the symptoms and signs of nasal congestion, open-mouth breathing, snoring, tongue, and quality of life of AH children and may be used as a long-term treatment for AH.

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Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy

Cited by 4 publications

References 13 publications

Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma

Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma

Efficacy of montelukast for adenoid hypertrophy in paediatrics: A systematic review and meta‐analysis

Effect of oral Xiao-xian decoction combined with acupoint application therapy on pediatric adenoid hypertrophy: A randomized trial

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