Clinical outcome of non–hCG-primed oocyte in vitro maturation treatment in patients with polycystic ovaries and polycystic ovary syndrome

Vos, Michel De; Ortega-Hrepich, Carolina; Albuz, F. K.; Guzmán, Luis; Polyzos, Nikolaos P.; Smitz, Johan; Devroey, Paul

doi:10.1016/j.fertnstert.2011.07.1108

Cited by 80 publications

(50 citation statements)

References 29 publications

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“…Several studies have reported pregnancies after IVM in PCOS with unstimulated cycles, also in cycles with FSH and hCG priming [2][3][4][5]. We believe that this is the first case report in which FSH priming was delayed until 13 th day of the cycle, when endometrial thickness reached 7 mm by endogenous estrogen.…”

Section: Discussionmentioning

confidence: 79%

See 1 more Smart Citation

Successful pregnancy following a novel endometrial preparation in a PCOS patient undergoing IVM: a case report

Eftekhar

Khalili

Aflatoonian

et al. 2012

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 79%

“…It was shown that pretreatment with FSH in the early days of folliculogenesis phase may increase the number of retrieved immature oocytes and/or maturation potential [5,6]. In addition, hCG priming promotes some GV oocytes to reach the MI stage and increases the maturation rate of immature oocytes in vitro setting.…”

Section: Introductionmentioning

confidence: 99%

Successful pregnancy following a novel endometrial preparation in a PCOS patient undergoing IVM: a case report

Eftekhar

Khalili

Aflatoonian

et al. 2012

J Assist Reprod Genet

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“…In our IVM protocol, we do not use hCG in vivo. We mature the oocyte in vitro putting them in the presence of FSH and hCG in the medium and satisfactory results with this technique were found (De Vos et al, 2011). The advantage of combining IVM of oocytes and vitrification of the embryos, is to postpone embryo transfer when the endometrium is sufficiently receptive.…”

Section: Discussionmentioning

confidence: 99%

In vitro Maturation of Oocytes in High Altitude Women with Polycystic Ovaries

Tominaga¹,

Pella²,

Lechuga³

et al. 2015

JBRA Assisted Reproduction

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Objective: Determine the effectiveness of in vitro maturation of oocytes in the infertility treatment in high altitude women with polycystic ovaries. Methods: Design: descriptive and retrospective study. Participants: Women with polycystic ovaries and infertility. Interventions: there were 11 women from locations above 7,546 feet above sea level with polycystic ovaries and infertility in which were performed in vitro maturation of oocytes, followed by intracytoplasmic sperm injection, culture and embryo vitrification. After that, the endometrium was prepared and the embryos were thawed and transferred. Main results mesurements: oocytes maturation, fertilization, clinical pregnancy and implantation rates. Results: Oocytes maturation rate was 86.1%; fertilization rate 90.3%; clinical pregnancy rate 36.4% and implantation rate 17.4%. Conclusions: In vitro maturation of oocytes is an effective technique in the infertility treatment of high altitude women with polycystic ovaries.

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“…Moreover, the huge increase in oestradiol secretion, that characterizes the late follicular expansion, plays a crucial role in triggering the LH surge, crucial for ovulation, and promoting endometrial receptivity [24]. The endometrium has been suggested to be a limiting factor in IVM cycles performed in the absence of hCG priming, as indicated by the fact that cryopreserved embryos display a higher implantation ability in comparison to fresh embryos [25]. However, such element does not not seem relevant to the present study, because our analysis included only IVM cycles primed with FSH and hGC.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes from mature oocytes derived from preovulatory and antral follicles: reflections on follicle physiology and oocyte competence

Fadini

Coticchio

Brambillasca

et al. 2014

J Assist Reprod Genet

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Purpose The aim of this retrospective study was to compare the competence of oocytes obtained from preovulatory and antral follicles. Methods Mature oocytes from preovulatory follicles were retrieved from women selected for standard IVF treatment (Group A). Mature oocytes from antral follicles were recovered from women undergoing hCG-primed in vitro maturation (IVM) treatment (Group B). Patients groups were matched for age, BMI, FSH, AMH and antral follicle count (AFC) values. In vivo matured oocytes from both groups were microinjected and resulting embryos were culture and selected on day 3 for embryo transfer. Results Oocyte pick-ups (OPU) were 315 and 204 in Groups A and B, respectively. Fertilization rates were comparable (72.8 and 75.9 %, respectively; P=0.137). In Group A, in which the average number of embryos transferred was higher, clinical pregnancy rates per OPU (37.5 %) and embryo transfer (38.4 %) were superior in comparison to Group B (27.0 %, P=0.013; 29.4 %, P=0.041; respectively). On the other hand, implantation rates (Group A, 23.7 %; Group B, 20.8 %) and proportions of babies born per transferred embryo (Group A, 19.5 %; Group B, 16.9 %) were similar (P=0.528 and 0.332, respectively). Conclusions Overall, this suggests that oocyte competence is already achieved at the antral stage of follicle development.

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Clinical outcome of non–hCG-primed oocyte in vitro maturation treatment in patients with polycystic ovaries and polycystic ovary syndrome

Cited by 80 publications

References 29 publications

Successful pregnancy following a novel endometrial preparation in a PCOS patient undergoing IVM: a case report

Successful pregnancy following a novel endometrial preparation in a PCOS patient undergoing IVM: a case report

In vitro Maturation of Oocytes in High Altitude Women with Polycystic Ovaries

Clinical outcomes from mature oocytes derived from preovulatory and antral follicles: reflections on follicle physiology and oocyte competence

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