“…Denudation of the cumulus and corona cells prior to ICSI reveal that approximately 15-20 % of the retrieved oocytes in COH protocols are immature [20,21]. However, there are still controversies about the safety of IVM, even though some cases of successful fertilization, embryo development, and pregnancy have been reported using clinical IVM [22,23]. But, in aforementioned studies, the immature oocytes derived from ICSI cycles were usually discarded.…”