“…On the other hand, once occlusion is established, the subsequent risk of cerebrovascular events seems to be lower (2% to 5% per year), even in initially symptomatic patients. [5][6][7][8]11,12 Color-coded Doppler ultrasound (CCDU) imaging is the first-line noninvasive method for the diagnosis of carotid artery disease, 13,14 featuring a high sensitivity (95%), specificity (100%), and accuracy (97%), even in differentiating a true occlusion from a near-occlusion. 15,16 Traditionally, despite a general complication rate as high as 5% and a stroke risk of 1.0%, the accepted reference test to confirm the presence of ICA stenosis or occlusion was selective contrast angiography.…”