Learning Objectives: On successful completion of this activity, participants should be able to (1) describe the role of myocardial perfusion imaging in preoperative risk assessment and (2) integrate current guidelines into the application of preoperative myocardial perfusion imaging.Financial Disclosure: The authors of this article have indicated no relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNM is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNM designates each JNM continuing education article for a maximum of 1.0 AMA PRA Category 1 Credit. Physicians should claim only credit commensurate with the extent of their participation in the activity.For CE credit, participants can access this activity through the SNM Web site (http://www.snm.org/ce_online) through May 2012.This review considers the changing nature of surgical risk assessment and the definition of risk; discusses the pathophysiology of perioperative myocardial infarction in relation to tests of coronary flow reserve; surveys the extensive literature on preoperative myocardial perfusion imaging (MPI) and outlines key trends; presents practical points on image interpretation; addresses the needs of special populations; compares MPI with other modalities; and integrates recommendations from practice guidelines on the effective use of MPI in the preoperative patient.