Primary lymphomas of the CNS are rare tumors accounting for less than 2% of all extranodal non-Hodgkin's lymphomas. The treatment for this disease has been disappointing. Radiation therapy and surgery have produced consistently poor control of this disease, with a median survival of 15 months. We have reviewed ten cases of primary lymphoma of the CNS treated at the Joint Center for Radiation Therapy or Dana-Farber Cancer Institute (Boston) from 1968 to 1981. All patients had biopsy-proven CNS lymphomas without systemic disease at presentation. In our series, control of CNS lymphoma was seen only in patients receiving craniospinal radiation or CNS-penetrating chemotherapy.

A method has been developed for the estimation of vasopressin in blood. By means of a few simple chemical and chromatographic procedures vasopressin contained in large quantities of blood may be extracted and obtained in small volumes of solution suitable for either bioassay determinations or further purification. These methods coupled with a bioassay procedure have been employed for the studj' of the time course of changes in the concentration of pressor material in the blood after hemorrhage. Evidence is presented that this pressor material is identical with vasopressin. From the results of these studies, an approximate rate and total discharge of vasopressin into blood of dogs subjected to hemorrhage was calculated.

Despite this unexpectedly high incidence of hypersensitivity among Hodgkin's disease patients treated with etoposide, rechallenge with the drug was successful in 78% of cases.

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