Clinical Outcomes in Cytomegalovirus-Positive Posner-Schlossman Syndrome Patients Treated With Topical Ganciclovir Therapy

Su, Chien‐Chia; Hu, Fung‐Rong; Wang, Tsing-Hong; Huang, Jen-Shang; Yeh, Po-Ting; Lin, Chang-Ping; Wang, I‐Jong

doi:10.1016/j.ajo.2014.08.007

Cited by 92 publications

(69 citation statements)

References 22 publications

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“…Similar to CMVR, there is a male predominance with 56-78% of CMV anterior uveitis patients being male. 117-120 CMV anterior uveitis can be acute or chronic. It can present like Posner-Schlossman syndrome or Fuchs’ heterochromic iridocyclitis and may be associated with acute relapsing or chronic raised intraocular pressure (IOP).…”

Section: Infectious Uveitidesmentioning

confidence: 99%

The Role of Sex in Uveitis and Ocular Inflammation

Yeung¹,

Popp²,

Chan³

2015

International Ophthalmology Clinics

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Uveitides can be due to non-infectious and infectious etiologies. It has been observed that there is a gender difference with a greater preponderance of non-infectious uveitis in women than in men. This review will describe both non-infectious and infectious uveitides and describes some of the current autoimmune mechanisms thought to be underlying the gender difference. It will specifically look at non-infectious uveitides with systemic involvement including juvenile idiopathic arthritis, spondyloarthopathies, sarcoidosis, Behçet’s disease, and Vogt-Koyanagi-Harada disease and at uveitides without systemic involvement including sympathetic ophthalmia, birdshot chorioretinitis, and the white dot syndromes. Infectious uveitides like acute retinal necrosis, progressive outer retinal necrosis, and cytomegalovirus mediated uveitis will be mentioned. Different uveitides with female- or male- predominance are presented and discussed.

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Section: Infectious Uveitidesmentioning

confidence: 99%

The Role of Sex in Uveitis and Ocular Inflammation

Yeung¹,

Popp²,

Chan³

2015

International Ophthalmology Clinics

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“…Recently, in clinical practice, PCR (polymerase chain reaction) testing of AH has enabled the detection of viral DNA (deoxyribonucleic acid) and enabled diagnosis of the cause in cases of AU that were previously labelled idiopathic. In addition, several studies have reported the identification of herpes virus in AH samples from patients with hypertensive refractive AU [16][17][18][19] . Among herpes viruses, it has been reported that cytomegalovirus (CMV) has a particularly strong association with PSS, with up to 52.2% of PSS patients testing positive for CMV 18,20 .…”

mentioning

confidence: 99%

Involvement of autotaxin in the pathophysiology of elevated intraocular pressure in Posner-Schlossman syndrome

Igarashi

Honjo

Yamagishi

et al. 2020

Sci Rep

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to examine whether autotaxin (AtX) in the aqueous humor causes elevated intraocular pressure (iop) in patients with posner-Schlossman syndrome (pSS). AtX and transforming growth factor beta (tGf-β) in the aqueous humor were quantified in PSS patients. The expression of ATX and TGF-β in cytomegalovirus (cMV)-infected-human trabecular meshwork (htM) cells was examined. Biological changes in htM cells and monkey Schlemm's canal endothelial (Sce) cells cultured in the conditioned medium of cMV-infected htM cells were analyzed. the expression of AtX and tGf-β1 was upregulated in the aqueous humor of cMV-positive pSS patients, and the level of AtX in the aqueous humor was positively correlated with iop. cMV infection upregulated AtX and tGf-β1 in hTM cells. The conditioned medium induced fibrotic changes in hTM cells and reduced SCE permeability, which was attenuated by an AtX inhibitor, a lysophosphatidic acid receptor antagonist, and a Rho kinase inhibitor. AtX in the aqueous humor induced by cMV infection may trigger elevated iop. Modulating AtX activity may be a novel treatment modality for pSS.

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“…It has previously been reported that GCV is effective in eliminating the CMV viral antigen, maintaining the control of IOP and preventing CEC loss in cases of CMV-positive PSS 16. It has also been reported that in patients with CMV endotheliitis who undergo corneal transplantation surgery, the postoperative recurrence of CMV is a serious complication that can lead to intractable graft failure 9.…”

Section: Discussionmentioning

confidence: 99%