Clinical Outcomes of ABO-Incompatible Kidney Transplantation in Patients with End-Stage Kidney Disease due to Diabetes Nephropathy

Uchida, Junji; Kosoku, Akihiro; Kabei, Kazuya; Nishide, Shunji; Shimada, Hideaki; Iwai, Tomoaki; Kuwabara, N.; Naganuma, Takeshi; Maeda, Keisuke; Kumada, Norihiko; Takemoto, Yoshiaki; Nakatani, Tatsuya

doi:10.1159/000496029

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…13 Although gender specificity is seen in most renal transplant cases, the exact underlying genetic cause leading up to it is still unknown. Along with gender, the mean age of patients with rejection issues are usually between 20-40 years, 14 which was in line with the results obtained in our study (mean age: 36.79 ± 10.65 years).…”

Section: Discussionsupporting

confidence: 91%

Frequency of Histological Patterns of Renal Allograft Biopsies– One Year of Renal Allograft Experience

Ahsan

Asif²,

Chauhan³

et al. 2022

PAFMJ

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Objective: To ascertain the frequency and spectrum of histopathological findings in renal allograft rejection cases received in one year. Study Design: Cross-sectional study. Place and Duration of Study: Histopathology Department of Armed Forces Institute of Pathology, Rawalpindi Pakistan from Jun 2020 to May 2021. Methodology: Renal allograft rejection biopsy cases of 62 male and female patients between the ages of 15-60 years having undergone renal transplant with prior end-stage renal disease over one year were collected. Frequency and histopathological findings were studied after classifying them according to the Banff Classification. Results: Cellular (T-cell mediated) rejection accounted for more than half of the cases under study, making it the most common cause of transplant rejection in our demographical area. It accounted for 28 (45.2%) slides of all the biopsies studied. Antibody-mediated rejection followed next with 17 (27.4%) slides, with seven slides (11.3%) of the cases borderline for changes accounting for a T-Cell mediated rejection. About 10 (16.2%) were non-specific changes negative for transplant rejection criteria. Conclusion: Our study was instrumental in establishing rejection patterns and major rejection sub-types while classified under the Banff Classification in our demographical area. The cataloguing of the cases and the major underlying cause would help minimize rejection rates resulting in better clinical outcomes and increased patient survival.

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Section: Discussionsupporting

confidence: 91%

Frequency of Histological Patterns of Renal Allograft Biopsies– One Year of Renal Allograft Experience

Ahsan

Asif²,

Chauhan³

et al. 2022

PAFMJ

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“…In Japan, ABO-incompatible kidney transplantation has become a popular alternative to deceased kidney transplantation due to the shortage of deceased donors [1, 2]. Splenectomy had been performed to reduce the B cell pool in ABO-incompatible kidney transplant recipients but is now being replaced by the administration of rituximab, an anti-CD20 antibody [3-5]. During the early era of ABO-incompatible kidney transplantation in Japan, splenectomy had been performed in ABO-incompatible kidney transplant recipients because Japanese insurance had not covered administration of rituximab for kidney transplantation.…”

Section: Introductionmentioning

confidence: 99%

Splenectomy for ABO-Incompatible Kidney Transplantation and Very Late-Onset Cytomegalovirus Disease

et al. 2020

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Introduction: Splenectomy had been previously performed in ABO-incompatible kidney transplantation to reduce the B cell pool. However, studies have shown that patients undergoing splenectomy may have a lifelong susceptibility to infection and mortality. Splenectomy may affect the incidence of cytomegalovirus (CMV) disease even at a very late stage after transplantation in ABO-incompatible recipients. Patients and Methods: Seven patients received their graft from an ABO-incompatible living donor at our institution and underwent splenectomy for B cell reduction. Among them, 3 recipients experienced very late-onset CMV disease approximately 10 years after their transplant and were enrolled in this study. Results: Very late-onset CMV disease occurred at 9 years and 9 months, 15 years, and 13 years and 5 months after transplantation, respectively. Two recipients suffered from CMV retinitis, while one experienced colitis. The age of the patients at onset of CMV disease was 69 years, 42 years, and 71 years, respectively. Conclusion: This may be the first report on very late-onset CMV disease after splenectomy in ABO-incompatible kidney transplantation. We should be aware that these recipients can experience very late-onset CMV disease even approximately 10 years after their transplant.

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Clinical Outcomes of ABO-Incompatible Kidney Transplantation in Patients with End-Stage Kidney Disease due to Diabetes Nephropathy

Cited by 4 publications

References 28 publications

Frequency of Histological Patterns of Renal Allograft Biopsies– One Year of Renal Allograft Experience

Frequency of Histological Patterns of Renal Allograft Biopsies– One Year of Renal Allograft Experience

Splenectomy for ABO-Incompatible Kidney Transplantation and Very Late-Onset Cytomegalovirus Disease

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