Clinical outcomes of VNS therapy with AspireSR® (including cardiac-based seizure detection) at a large complex epilepsy and surgery centre

Hamilton, Preci; Soryal, Imad; Dhahri, Prince A.; Wimalachandra, Welege Samantha Buddhika; Leat, Anna; Hughes, Denise; Toghill, Nicole; Hodson, James; Sawlani, Vijay; Hayton, Tom; Samarasekera, Shanika; Bagary, Manny; McCorry, Dougall; Chelvarajah, Ramesh

doi:10.1016/j.seizure.2018.03.022

Cited by 86 publications

(54 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, RNS is closed-loop, meaning that stimulation is delivered only when certain conditions are detected by the device [9]. More recent models of VNS have a sensing component, by which stimulation is provided when tachycardia is present [10].…”

Section: Introductionmentioning

confidence: 99%

A Review of Neurostimulation for Epilepsy in Pediatrics

et al. 2019

View full text Add to dashboard Cite

Neurostimulation for epilepsy refers to the application of electricity to affect the central nervous system, with the goal of reducing seizure frequency and severity. We review the available evidence for the use of neurostimulation to treat pediatric epilepsy, including vagus nerve stimulation (VNS), responsive neurostimulation (RNS), deep brain stimulation (DBS), chronic subthreshold cortical stimulation (CSCS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). We consider possible mechanisms of action and safety concerns, and we propose a methodology for selecting between available options. In general, we find neurostimulation is safe and effective, although any high quality evidence applying neurostimulation to pediatrics is lacking. Further research is needed to understand neuromodulatory systems, and to identify biomarkers of response in order to establish optimal stimulation paradigms.

show abstract

Section: Introductionmentioning

confidence: 99%

A Review of Neurostimulation for Epilepsy in Pediatrics

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Seventy percent of patients could have significant additional seizure reduction with the Model 106. 37) Another study also revealed that VNS with AutoStim Mode achieved maintenance of prior-established seizure control with markedly less energy consumption and improved seizure control as compared to the previous models. 38) Patients who did not respond to the previous models only with the open-loop system may obtain seizure reduction by replacement to the Model 106 even though output currents and duty cycles were reduced.…”

Section: Implantable Devices For Medically Refractory Epilepsymentioning

confidence: 93%

Recent Advancement of Technologies and the Transition to New Concepts in Epilepsy Surgery

Yamamoto

2020

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

“…The study involved patients under the care of one surgeon who had received new insertions of the model (51 patients) and those that had old VNS models that were updated at battery change (62 patients). The new (59% at a median of 13 months after insertion) and changed model patients both had better than expected responder rates over the period including a high rate of patients experiencing an additional seizure reduction in the changed model patients (71% had > 50% reduction in seizures following battery change) [106].…”

Section: Closed Loop Neurostimulationmentioning

confidence: 99%

Neural stimulation systems for the control of refractory epilepsy: a review

Bigelow

Kouzani

2019

J NeuroEngineering Rehabil

View full text Add to dashboard Cite

Epilepsy affects nearly 1% of the world’s population. A third of epilepsy patients suffer from a kind of epilepsy that cannot be controlled by current medications. For those where surgery is not an option, neurostimulation may be the only alternative to bring relief, improve quality of life, and avoid secondary injury to these patients. Until recently, open loop neurostimulation was the only alternative for these patients. However, for those whose epilepsy is applicable, the medical approval of the responsive neural stimulation and the closed loop vagal nerve stimulation systems have been a step forward in the battle against uncontrolled epilepsy. Nonetheless, improvements can be made to the existing systems and alternative systems can be developed to further improve the quality of life of sufferers of the debilitating condition. In this paper, we first present a brief overview of epilepsy as a disease. Next, we look at the current state of biomarker research in respect to sensing and predicting epileptic seizures. Then, we present the current state of open loop neural stimulation systems. We follow this by investigating the currently approved, and some of the recent experimental, closed loop systems documented in the literature. Finally, we provide discussions on the current state of neural stimulation systems for controlling epilepsy, and directions for future studies.

show abstract

Clinical outcomes of VNS therapy with AspireSR® (including cardiac-based seizure detection) at a large complex epilepsy and surgery centre

Cited by 86 publications

References 19 publications

A Review of Neurostimulation for Epilepsy in Pediatrics

A Review of Neurostimulation for Epilepsy in Pediatrics

Recent Advancement of Technologies and the Transition to New Concepts in Epilepsy Surgery

Neural stimulation systems for the control of refractory epilepsy: a review

Contact Info

Product

Resources

About