Clinical parameters associated with collateral development in patients with chronic total coronary occlusion

Abstract

In this unique cohort, high serum leucocytes and high diastolic blood pressure are associated with poorly developed collaterals. Interestingly, the use of β blockers is associated with well-developed collaterals, shedding new light on the potential action mode of this drug in patients with CAD.

Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion

“…Consistent with previous angiographic studies (Boodhwani et al, 2006;Wang et al, 2013;van der Hoeven et al, 2013), our results indicated that coronary collateral development was lower in females and declined with increasing age of the patients. In contrast, well-developed collaterals were more frequently detected in hypertensive patients than in their non-hypertensive counterparts.…”

“…In experimental animal studies, hyperlipidemia, particularly hypercholesterolemia, was shown to be an inhibitor of arteriogenesis (Lin et al, 2010). However, data on the relationship between coronary collateral formation and hyperlipidemia remain controversial, partly because of the use of different techniques for grading the collateral flow (van der Hoeven et al, 2013).…”

A new risk scoring model for prediction of poor coronary collateral circulation in acute non-ST-elevation myocardial infarction

“…A recent study relieved that increased CD14++CD16-monocyte count predicts good collateralization in patients with stable angina [15]. On the other hand, two previous papers found increased leukocyte counts to be associated with poorly developed CCC in chronic total occlusion [16,17]. In contrast to these findings, some investigators think that proinflammatory enzymes and cytokines released from these cells rather than leukocytes may play a role on collateral development in chronic total occlusion [18].…”

Coronary artery dominance dependent collateral development in the human heart

“…The result of the present study corroborated the finding of Fujita et al [4] who also used a cut-off age of 60 years and reported that the extent of coronary collateral development was similar in patients regardless of their age. Furthermore, van der Hoeven et al [22] in their study divided patients into two groups (≤ 64 years and ≥ 65 years) and also found no association between higher age and the development of poor collaterals. Conversely, it differed from the reports of Nakae et al [14] and Sun et al [19] who stated that well-developed collaterals were significantly lower in patients older than > 65 years of age.…”