Clinical, pathological, and radiological characteristics of solitary ground-glass opacity lung nodules on high-resolution computed tomography

Qiu, Zhixin; Cheng, Yue; Liú, Dan; Wang, Wei-Ya; Wu, Xia; Wu, Weilu; Li, Weimin

doi:10.2147/tcrm.s110363

Cited by 32 publications

(26 citation statements)

References 15 publications

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“…Numerous studies proved that the CT findings were useful for evaluating the histological nature of the tumors and correlated with the IASLC/ATS/ERS classification [ 8 – 10 ]. Our results showed that benign lesions only accounted for 7.1%, the reason may be the selection of candidate patients for surgery.…”

Section: Discussionmentioning

confidence: 99%

Identification of preoperative prediction factors of tumor subtypes for patients with solitary ground-glass opacity pulmonary nodules

Wang

Chen

et al. 2018

J Cardiothorac Surg

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BackgroundRecent wide spread use of low-dose helical computed tomography for the screening of lung cancer have led to an increase in the detection rate of very faint and smaller lesions known as ground-glass opacity nodules. The purpose of this study was to investigate the clinical factors of lung cancer patients with solitary ground-glass opacity pulmonary nodules on computed tomography.MethodsA total of 423 resected solitary ground-glass opacity nodules were retrospectively evaluated. We analyzed the clinical, imaging and pathological data and investigated the clinical differences in patient with adenocarcinoma in situ / minimally invasive adenocarcinoma and those with invasive adenocarcinoma.ResultsThree hundred and ninety-three adenocarcinomas (92.9%) and 30 benign nodules were diagnosed. Age, the history of family cancer, serum carcinoembryonic antigen level, tumor size, ground-glass opacity types, and bubble-like sign in chest CT differed significantly between adenocarcinoma in situ / minimally invasive adenocarcinoma and invasive adenocarcinoma (p:0.008, 0.046, 0.000, 0.000, 0.000 and 0.001). Receiver operating characteristic curves and univariate analysis revealed that patients with more than 58.5 years, a serum carcinoembryonic antigen level > 1.970 μg/L, a tumor size> 13.50 mm, mixed ground-glass opacity nodules and a bubble-like sign were more likely to be diagnosed as invasive adenocarcinoma. The combination of five factors above had an area under the curve of 0.91, with a sensitivity of 82% and a specificity of 87%.ConclusionThe five-factor combination helps us to distinguish adenocarcinoma in situ / minimally invasive adenocarcinoma from invasive adenocarcinoma and to perform appropriate surgery for solitory ground-glass opacity nodules.

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Section: Discussionmentioning

confidence: 99%

Identification of preoperative prediction factors of tumor subtypes for patients with solitary ground-glass opacity pulmonary nodules

Wang

Chen

et al. 2018

J Cardiothorac Surg

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“…mGGNs are more frequently pathologically diagnosed as invasive adenocarcinoma; however, AIS and MIA more often present as pGGNs on the contrary. 8 In malignant part-solid GGNs, the solid part histologically represents invasion, whereas the pure GGO areas are considered as lepidic components of adenocarcinoma. Solid transformation of GGNs is thus considered a strong indicator of malignancy.…”

Section: Categories Of Ggnsmentioning

confidence: 99%

New horizons in surgical treatment of ground-glass nodules of the lung: experience and controversies

Chen¹,

Dai²,

Kadeer³

et al. 2018

TCRM

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Ground-glass nodule (GGN) is defined as a nodular shadow with ground-glass opacity that is generally associated with the early-stage lung adenocarcinoma. Nowadays, GGNs of the lung are increasingly detected with thin-section computed tomography scan. GGNs are categorized as pure GGNs and mixed GGNs according to the images from a high-resolution computed tomography. Meanwhile, it is routine to divide GGNs into different categories according to the number, solitary, or multiple, the management of which there is very different. A great number of studies have been conducted to analyze the different characteristics of GGNs in various aspects ranging from radiology, pathology, and surgery to molecular biology. However, plenty of problems still remain unsolved, ranging from the preoperative localization to intraoperative surgical resection procedure, the lymphadenectomy, and sampling of lymph nodes, as well as the accuracy of frozen sections. There has been a large volume of updated published information summarizing recently emerging and rapidly progressing aspects of surgical treatment of solitary and multiple GGNs with the unsolved problems mentioned above. However, there have been few specific reviews of surgical treatment of GGNs so far. This review presents a timely outline of advances in relevant experience and controversies of GGNs for a better understanding of this kind of lesion.

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“…Based on their density features on computed tomography (CT) images, cancerous nodules can be generally divided into solid and subsolid nodules, each with significantly different morphological and pathological features [3]. Several studies have been conducted on the differential diagnosis of benign and malignant subsolid nodules [4][5][6][7][8] and the solid ones [9][10][11][12][13]. Compared with subsolid lung cancerous nodules, the solid ones have a worse prognosis because of their rapid growth [14][15][16] and earlier metastases [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Primary solid lung cancerous nodules with different sizes: computed tomography features and their variations

Chu

Zhang

et al. 2019

BMC Cancer

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Background:The computed tomography (CT) features of small solid lung cancers and their changing regularity as they grow have not been well studied. The purpose of this study was to analyze the CT features of solid lung cancerous nodules (SLCNs) with different sizes and their variations. Methods: Between February 2013 and April 2018, a consecutive cohort of 224 patients (225 nodules) with confirmed primary SLCNs was enrolled. The nodules were divided into four groups based on tumor diameter (A: diameter ≤ 1.0 cm, 35 lesions; B: 1.0 cm < diameter ≤ 1.5 cm, 60 lesions; C: 1.5 cm < diameter ≤ 2.0 cm, 63 lesions; and D: 2.0 cm < diameter ≤ 3.0 cm, 67 lesions). CT features of nodules within each group were summarized and compared.Results: Most nodules in different groups were located in upper lobes (groups A − D:50.8%-73.1%) and had a gap from the pleura (groups A − D:89.6%-100%). The main CT features of smaller (diameter ≤ 1 cm) and larger (diameter > 1 cm) nodules were significantly different. As nodule diameter increased, more lesions showed a regular shape, homogeneous density, clear but coarse tumor-lung interface, lobulation, spiculation, spinous protuberance, vascular convergence, pleural retraction, bronchial truncation, and beam-shaped opacity (p < 0.05 for all). The presence of halo sign in all groups was similar (17.5%-22.5%; p > 0.05). Conclusions:The CT features vary among SLCNs with different sizes. Understanding their changing regularity is helpful for identifying smaller suspicious malignant nodules and early determining their nature in follow-up.

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Clinical, pathological, and radiological characteristics of solitary ground-glass opacity lung nodules on high-resolution computed tomography

Cited by 32 publications

References 15 publications

Identification of preoperative prediction factors of tumor subtypes for patients with solitary ground-glass opacity pulmonary nodules

Identification of preoperative prediction factors of tumor subtypes for patients with solitary ground-glass opacity pulmonary nodules

New horizons in surgical treatment of ground-glass nodules of the lung: experience and controversies

Primary solid lung cancerous nodules with different sizes: computed tomography features and their variations

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