Clinical Pathology of Yellow Fever

Elton, Norman W.; Romero, A.; Trejos, A.

doi:10.1093/ajcp/25.2.135

Cited by 42 publications

(13 citation statements)

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“…[16][17][18] Microvesicular steatosis is a prominent microscopic feature of YFV infection in liver of susceptible vertebrate hosts, including humans, monkeys, or hamsters. 8,[19][20][21][22][23] In the hamster YF model, small numbers of minute fatty vesicles start to appear in some of the hepatocytes by the third or fourth day after YFV infection; by the fifth or sixth day, the fatty vesicles have spread to involve more cells in larger areas, and they usually occupy the entire cytoplasm ( Figure 3G and H).…”

Section: Discussionmentioning

confidence: 99%

Alteration of Clinical Outcome and Histopathology of Yellow Fever Virus Infection in a Hamster Model by Previous Infection With Heterologous Flaviviruses

Xiao¹,

Guzmán²,

Rosa³

et al. 2003

The American Journal of Tropical Medicine and Hygiene

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Abstract. Using a recently described hamster model of severe yellow fever (YF), we examined the hypothesis that prior infection with heterologous flaviviruses protects against severe or fatal YF. Hamsters were singly or sequentially infected with Japanese encephalitis, St. Louis encephalitis, West Nile, and/or dengue-1 viruses, and then challenged with a virulent strain of yellow fever virus (YFV). In contrast to control (naive) hamsters, many of which appeared clinically ill or died after YFV infection, the flavivirus-immune animals remained asymptomatic. The flavivirus-immune hamsters also had a reduced viremia and lower serum levels of alanine aminotransferase and total bilirubin, compared with naive hamsters, following YFV infection. Histologically, livers of animals in the flavivirus-immune and control groups showed comparable levels of multifocal necrapoptosis. However, steatosis was not observed in the flavivirus-immune animals, whereas naive hamsters developed extensive microvesicular steatosis in the liver following YFV infection. These findings suggest that hepatocytic steatosis is an adverse microscopic feature associated with severe disease in YFV infection. Our experimental results support earlier anecdotal reports that prior exposure of humans to heterologous flaviviruses reduces subsequent risk of fatal YFV infection.

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Section: Discussionmentioning

confidence: 99%

Alteration of Clinical Outcome and Histopathology of Yellow Fever Virus Infection in a Hamster Model by Previous Infection With Heterologous Flaviviruses

Xiao¹,

Guzmán²,

Rosa³

et al. 2003

The American Journal of Tropical Medicine and Hygiene

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“…Furthermore, the laboratory and histopathologic findings in patients with DHF can mimic those of severe cases of yellow fever (YF) and arenaviral hemorrhagic fever (AHF). All three of these diseases can produce leukopenia, thrombocytopenia, elevated serum transaminase levels, liver necrosis, and Councilman bodies (eosinophilic depositions in hepatocytes) (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). This is an important consideration, since correct diagnosis and early recognition of any of these diseases is essential for their treatment, as well as for the appropriate public health response.…”

Section: Dengue Hemorrhagic Fevermentioning

confidence: 99%

“…Clinically, the two diseases may be similar: acutely ill patients with fever, leukopenia and hemorrhagic manifestations (7)(8)(9)(10)(11)(12)(13). Although YF patients often have icterus, this is not always obvious in people with dark skin.…”

Section: Yellow Fevermentioning

confidence: 99%

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Fiebres virales hemorrágicas en Suramérica

Tesh

2002

biomedica

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This paper reviews the epidemiology and distinguishing features of three viral hemorrhagic fevers (dengue hemorrhagic fever, yellow fever and arenaviral hemorrhagic fever) that have emerged as important public health problems in South America. Although the etiology, natural history and control of the three diseases are different, their clinical manifestations and histopathology findings are similar and can be difficult to differentiate. Consequently, early recognition and correct diagnosis are essential for effective control measures to be initiated.

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“…La elevación marcada de las enzimas hepáticas, suele tener una característica especial en los pacientes en fase de intoxicación por fiebre amarilla, que se caracteriza por el predominio de TGO sobre TGP en el examen bioquímico, esto es debido a daño viral a nivel de miocardio y de musculo esquelético que se da en fiebre amarilla. Asimismo, el trastorno de la coagulación, es una característica de esta enfermedad, que le da su nombre de fiebre viral hemorrágica[9,10].El diagnóstico confirmatorio en ambos casos, se realizó mediante serología (inmunoglobulina M). Existen otros métodos diagnósticos como reacción en cadena de polimerasa (PCR) y el aislamiento viral por cultivo, que son útiles durante la fase febril y de remisión donde la carga virémica es más alta.Fiebre amarilla Medina-Collado C & Mejía Cordero F…”

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Fiebre amarilla, dos formas clínicas diferentes de una misma enfermedad. A propósito de 2 casos

Medina-Collado

Mejía

2016

Acta Med Peru

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La fiebre amarilla es una enfermedad infecciosa viral hemorrágica transmitida por la picadura de mosquitos y con un espectro clínico variado. En el Perú se presentan en brotes, en diferentes partes de la selva alta y baja. A pesar de tener elevada mortalidad, es una enfermedad inmunoprevenible con la vacunación que no siempre es seguida por los viajeros. Reportamos dos casos clínicos, con dos espectros clínicos distintos de una misma enfermedad en una pareja de jóvenes previamente sanos, que viajaron por turismo a la selva central del Perú, en la provincia de Chanchamayo, Junín. Se debe recordar a todo viajero a la selva peruana a vacunarse previamente contra la fiebre amarilla.

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Clinical Pathology of Yellow Fever

Cited by 42 publications

References 0 publications

Alteration of Clinical Outcome and Histopathology of Yellow Fever Virus Infection in a Hamster Model by Previous Infection With Heterologous Flaviviruses

Alteration of Clinical Outcome and Histopathology of Yellow Fever Virus Infection in a Hamster Model by Previous Infection With Heterologous Flaviviruses

Fiebres virales hemorrágicas en Suramérica

Fiebre amarilla, dos formas clínicas diferentes de una misma enfermedad. A propósito de 2 casos

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