2016
DOI: 10.1002/hep.28368
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Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study

Abstract: on behalf of the HCC-NAFLD Italian Study Group* Nonalcoholic fatty liver disease (NAFLD) represents the hepatic manifestation of metabolic syndrome and may evolve into hepatocellular carcinoma (HCC). Only scanty clinical information is available on HCC in NAFLD. The aim of this multicenter observational prospective study was to assess the clinical features of patients with NAFLD-related HCC (NAFLD-HCC) and to compare them to those of hepatitis C virus (HCV)-related HCC. A total of 756 patients with either NAFL… Show more

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Cited by 527 publications
(568 citation statements)
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“…At variance with other etiologies, however, NAFLD-HCC is associated with a less striking prevalence in the male gender and may occur in the absence of cirrhosis [168][169][170]. Given that these NAFLD individuals escape surveillance programs, NAFLD-HCC often undergoes a diagnostic delay which curtails the chances for radical treatment and accounts for a worse prognosis compared to other etiologies of disease, such as hepatitis B virus (HBV)-HCC and HCV-HCC [171,172].…”
Section: Hepatocellular Carcinomamentioning
confidence: 99%
“…At variance with other etiologies, however, NAFLD-HCC is associated with a less striking prevalence in the male gender and may occur in the absence of cirrhosis [168][169][170]. Given that these NAFLD individuals escape surveillance programs, NAFLD-HCC often undergoes a diagnostic delay which curtails the chances for radical treatment and accounts for a worse prognosis compared to other etiologies of disease, such as hepatitis B virus (HBV)-HCC and HCV-HCC [171,172].…”
Section: Hepatocellular Carcinomamentioning
confidence: 99%
“…Развитие ГЦР без цирроза печени является относительно редким явлением и отмечается ори-ентировочно у 5% больных хроническим вирус-ным гепатитом, однако F. Piscaglia et al [38] по-казали, что у 50 % больных НАЖБ ГЦР может возникать и при отсутствии цирроза. R.B.…”
Section: ____________________________________________________________unclassified
“…However, 15-40% of such patients may progress to NASH which can be life threatening [8]. 15% of NASH patients can progress to cirrhosis in 10-15 years [9] and cirrhosis increases the risk of HCC by 10% [10,11]. In addition, NAFLD increases the risk for various other cancers, particularly in the gastrointestinal tract (colon, oesophagus, stomach, and pancreas) and extra-intestinal sites (kidney, prostate, breast) [12].…”
Section: Introductionmentioning
confidence: 99%