Clinical performance of a hybrid presbyopia-correcting intraocular lens in patients undergoing cataract surgery in a multicenter trial

Abstract

Purpose: To compare the clinical performance of TECNIS Synergy intraocular lens (IOL), model ZFR00V, vs TECNIS IOL, model ZCB00, in cataract patients. Setting: Multicenter clinical setting. Design: Prospective, randomized, subject/evaluator-masked clinical trial. Methods: Cataract patients aged ≥22 years were randomly assigned 1:1 to bilateral implantation with ZFR00V or ZCB00. Key end points at 6 months postsurgery included monocular and binocular visual acuities at 4 m, 66 cm, 33 cm, and/or 40 cm, binocular distance-corrected defocus testing, patient-reported outcomes, and safety. Results: 272 patients were implanted with ZFR00V (135) or ZCB00 (137). At 6 months, 83/131 (63.4%) ZFR00V patients demonstrated 20/25 or better combined monocular distance-corrected vision at far, intermediate, or near, compared with 5/130 (3.8%) ZCB00 patients. ZFR00V demonstrated excellent binocular uncorrected vision at intermediate (0.022 logMAR) and distance-corrected vision at 40 cm (0.047 logMAR). Strong ZFR00V performance persisted under mesopic conditions (0.244 logMAR or ∼20/32 Snellen), where improvement over ZCB00 with distance-corrected vision at near was 3.5 lines. ZFR00V provided a broad range of functional vision (20/32 or better) through −3.5 diopters of defocus (29 cm). Most ZFR00V patients reported no spectacle wear overall (93.1%) or at all 4 viewing distances combined (87.8%), and 55.7% qualified as completely spectacle independent. Relatively low proportions of ZFR00V patients reported being very/extremely bothered by halos (13.7%), starbursts (11.5%), or night glare (8.4%). The safety profile was similar between IOL groups. Conclusions: TECNIS Synergy ZFR00V demonstrated improved intermediate and near vision, increased range of vision, and greater spectacle independence vs TECNIS monofocal ZCB00.

Comparative Analysis of two presbyopia correction IOLs: Objective and Subjective Visual Outcomes

“…[4,10,11] In this study, the results obtained in the defocus curve of the Panoptix lens matched those reported in previous studies on the comparison of other trifocal lenses. [2,3,[6][7][8][9][11][12][13][14][15][16][17][18][19][20] Panoptix lens has achieved superior results to the ATLISA IOL (Zeiss, Germany)) in the near (40 cm) and intermediate (60 cm) views and still showed similar performances at medium distance (80 cm) and far distances. [2] A systematic review concluded the improved visual results of Panoptix IOL for near distances (40 cm) compared with those of Symfony lens (ZXR00-J&J).…”

“…The clinical results obtained in our defocus curve for the Synergy lens were compatible with those of previous studies on the same lens, which demonstrated good continuous VA from a distance, near (40 cm), and intermediate vision (60 cm). [4,10,11,19,20] In both groups, the two patients with the lowest degree of postoperative visual satisfaction reported di culty in activities from near vision because of the need for increased light for extended reading or manual activities, which caused di culty in performing these tasks. However, both patients could read the 0.1 line of the logMAR scale during clinical evaluation without di culty under adequate lighting conditions.…”

Comparison of Distance-Based Uncorrected Visual Acuity Based on the Optical Profile of Same Platform IOLs

“…By comparison, the continuous focus lens ensures optimal UCVA from near to far distances and aims for spectacle independence. [10][11][12] However, it is suggested that the contrast sensitivity may decrease relative to those of the other three IOL types.…”