Clinical performance of titanium-zirconium implants with a hydrophilic surface in patients with controlled type 2 diabetes mellitus: 2-year results from a prospective case-control clinical study

Cabrera-Domínguez, José; Castellanos-Cosano, Lizett; Torrés-Lagares, Daniel; Pérez-Fierro, Manuel; Machuca-Portillo, Guillermo

doi:10.1007/s00784-019-03110-9

Cited by 17 publications

(15 citation statements)

References 54 publications

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“…This benefit to implant integration was not found in a subsequent study with the same split‐mouth design applied to PC diabetics and non‐diabetic controls 38 . In a prospective study of WC diabetics (mean HbA1c = 7%) and non‐diabetic controls receiving modSLA implants, a 100% success and survival rate was found in both groups, despite a higher prevalence of type III bone in the group with T2DM 39,40 . The present study provides similar findings in a PC population and corroborates these results with dPROs.…”

Section: Discussionsupporting

confidence: 86%

“…Generally, other clinical studies have reported 100% survival rates for mod-SLA, Ti-Zr implants placed in PC patients with T2DM. [38][39][40] Aguilar-Salvatierra and coworkers reported 2-year survival rates of 96.6% and 86.3% for PC individuals with HbA1c levels ranging from 6.1% to 8% and 8.1% to 10%, respectively. 41 When comparing non-diabetic and diabetic individuals, a recent systematic review found no significant difference in implant survival rates.…”

Section: Discussionmentioning

confidence: 99%

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Clinical performance of hydrophilic, titanium‐zirconium dental implants in patients with well‐controlled and poorly controlled type 2 diabetes: One‐year results of a dual‐center cohort study

Latimer,

Roll,

Daubert

et al. 2022

Journal of Periodontology

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Background This study assessed the clinical performance of hydrophilic dental implants in a patient cohort with type 2 diabetes mellitus (T2DM). Methods Subjects with T2DM of ≥2‐years duration were allocated to either the well‐controlled (WC; HbA1c ≤ 7.0%,) or poorly‐controlled (PC; 7.5 < HbA1c < 10%) groups in a dual‐center, prospective cohort study. Each subject received a single, titanium‐zirconium (Ti‐Zr) dental implant with a chemically‐modified, hydrophilic (modSLA) surface in a posterior mandibular site. Postoperatively, subjects were followed at 1, 2, 4, 8, and 12‐week intervals. Post‐loading, subjects were followed at 3, 6, and 12‐months. Clinical and radiographic parameters of implant success, and dental patient‐reported outcomes were collected. Results Twenty‐one dental patients (NWC = 11; NPC = 10; mean age: 66.8 ± 7.5 years) were enrolled and the 1‐year implant success rate was 100%. Peri‐implant bone levels were stable with 0.15 ± 0.06 mm mean marginal loss at 1 year without significant inter‐group differences (P = 0.79). Postoperative pain was minimal at 1‐week, and OHIP‐5 scores decreased significantly over time as compared with preoperative levels (P < 0.001) suggesting significant improvement in patient‐perceived oral health following implant therapy. Conclusions Elevated HbA1c levels > 7.5% did not compromise 1‐year success rates, or oral health‐related quality of life in PC patients receiving modSLA, Ti‐Zr implants. Given that implant placement up to 10% HbA1c significantly enhanced oral health‐related quality of life without complications or morbidity, the safety and efficacy of implants to improve oral function in T2DM is supported, even without ideal glycemic control.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Clinical performance of hydrophilic, titanium‐zirconium dental implants in patients with well‐controlled and poorly controlled type 2 diabetes: One‐year results of a dual‐center cohort study

Latimer,

Roll,

Daubert

et al. 2022

Journal of Periodontology

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“…The implants used in their study had bone level shape without the machined collar such as the tissue level implants. The latter used together with bone level implants revealed a mean MBL of 0.71 ± 0.58 mm and 1.55 ± 0.46 mm, respectively assessed in a clinical trial 2 years after prosthetic loading [32]. A narrative review pointed out that the tissue level implant was positively correlated with crestal bone level maintenance as the distance between bone crest and the margin of prosthetic restoration automatically exceeds 1.5 mm, a factor listed as one of the prerogatives against the onset of peri-implant lesions [33].…”

Section: Discussionmentioning

confidence: 98%

One-year performance of posterior narrow diameter implants in hyperglycemic and normo-glycemic patients—a pilot study

et al. 2021

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Objectives The aim of the study was to compare the performance of narrow diameter implants in patients with uncontrolled diabetes mellitus type 2 (T2DM) and normo-glycemic individuals during the first 12 months after implant loading. Material and methods In 16 T2DM patients with HbA1C > 6.5% (test group) and 16 normo-glycemic patients (HbA1C < 6.0%; control group), one to two narrow diameter tissue level implants were placed in the posterior maxilla or mandible. After 3-month lasting integration period, implants were loaded by fixed dentures. The clinical parameters probing depth (PD), bleeding on probing (BOP), attachment loss (CAL), recession and papilla bleeding index (PBI) were assessed manually at loading and after 12 months of function. The paired digital periapical radiographs were analyzed with regard to the change in marginal bone level (MBL) from baseline to 12 months’ control. The mean values calculated for both patient groups were statistically analyzed. The technical complications were recorded. Results The T2DM group accounted 13 patients due to 3 dropouts. The overall implant survival rate after 12 months was 100%. The differences in means for the clinical parameters and the MBL were statistically non-significant between the T2DM and normo-glycemic patients for the short period of loaded function reported here. No technical complications were recorded. Conclusions The study demonstrated an encouraging clinical outcome with narrow diameter implants in patients with uncontrolled T2DM compared to non-diabetics after 12 months post loading. For the short observation period, no biological and technical complications were reported regardless the glycemic status. Clinical relevance Patients with HbA1C > 6.5% may benefit from the treatment with narrow diameter implants by avoiding complex surgical interventions with augmentation procedures. Trial registration Clinicaltrials.gov: NCT04630691

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“…However, a recent 5-year follow-up [46] concluded that smoking had no effect on peri-implant tissues surrounding Ti-or TiZr-implants, concomitantly highlighting the role of routine oral hygiene maintenance. Also, when it comes to patients with well-controlled diabetes mellitus type 2, the prognosis for TiZr-implants seems to be equally good as for subjects with normal glycemic level [47].…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study with Randomised Controlled Design Comparing TiZr Alloy Dental Implants to Ti Implants

Hultin

Eriksson

Backe

et al. 2020

JOMR

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Objectives Evidence on the clinical performance of recently introduced dental implants in titanium-zirconium alloy is sparse. The aim of the present pilot study with randomized controlled design is to compare changes in supporting structures around dental titanium-zirconium alloy implants to commercially pure titanium implants. Material and Methods The present material includes consecutive patients referred to a specialist clinic in Sweden. Two patient groups treated with dental implants in two different materials - titanium (Ti) and titanium-zirconium (TiZr) - were defined after block randomisation for smoking. In total, 40 implants installed in 21 patients were available for one-year follow-up. Marginal bone level, soft tissue height and width of keratinised mucosa were registered at baseline and at one-year follow-up. Results At implant level, the test group (TiZr) yielded significant marginal bone loss (P < 0.001) after one year. Additionally, marginal bone loss after one year was significantly higher for TiZr implants (P < 0.001) as compared to traditional Ti implants. Soft tissue dimensions were stable throughout the evaluation time for both implant materials. Conclusions One-year results indicate more pronounced initial marginal bone loss for dental implants in titanium-zirconium alloy as compared to implants made of commercially pure titanium.

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Clinical performance of titanium-zirconium implants with a hydrophilic surface in patients with controlled type 2 diabetes mellitus: 2-year results from a prospective case-control clinical study

Cited by 17 publications

References 54 publications

Clinical performance of hydrophilic, titanium‐zirconium dental implants in patients with well‐controlled and poorly controlled type 2 diabetes: One‐year results of a dual‐center cohort study

Clinical performance of hydrophilic, titanium‐zirconium dental implants in patients with well‐controlled and poorly controlled type 2 diabetes: One‐year results of a dual‐center cohort study

One-year performance of posterior narrow diameter implants in hyperglycemic and normo-glycemic patients—a pilot study

A Pilot Study with Randomised Controlled Design Comparing TiZr Alloy Dental Implants to Ti Implants

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