Clinical Pharmacokinetic Evaluation of Optimized Liquisolid Tablets as a Potential Therapy for Male Sexual Dysfunction

Alotaibi, Fayez O; Alhakamy, Nabil A.; Omar, Abdelsattar M.; El-Say, Khalid M.

doi:10.3390/pharmaceutics12121187

Cited by 4 publications

(1 citation statement)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concept of liquisolid tablets was developed initially from powdered solution technology that can be used to formulate liquid medication. A liquisolid system is defined as dry, non-adherent, free-flowing and compressible powder mixtures converted from liquid drugs, drug suspensions or drug solutions in nonvolatile solvents with selected carriers and coating materials [7][8][9]. In this technique, the drug is dissolved in a non-volatile solvent and converted into a dry, free flowing, and compressible solid using carrier and coating materials.…”

Section: Introductionmentioning

confidence: 99%

Formulation Development of Mirtazapine Liquisolid Compacts: Optimization Using Central Composite Design

Naureen

Shah

et al. 2022

Molecules

View full text Add to dashboard Cite

Mirtazapine is a tetracyclic anti-depressant with poor water solubility. The aim of this study was to improve the dissolution rate of mirtazapine by delivering the drug as a liquisolid compact. Central composite design (CCD) was employed for the preparation of mirtazapine liquisolid compacts. In this, the impacts of two independent factors, i.e., excipient ratio (carrier:coating) and different drug concentration on the response of liquisolid system were optimized. Liquisolid compacts were prepared using propylene glycol as a solvent, microcrystalline cellulose as a carrier, and silicon dioxide (Aerosil) as the coating material. The crystallinity of the formulated drug and the interactions between the excipients were examined using X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR), respectively. The dissolution study for the liquisolid compact was carried out as per FDA guidelines. The results showed loss of crystallinity of the mirtazapine in the formulation and was completely solubilized in non-volatile solvent and equally dispersed throughout the powder system. Moreover, drug dissolution was found to be higher in liquisolid compacts than the direct compressed conventional tablets (of mirtazapine). The liquisolid technique appears to be a promising approach for improving the dissolution of poorly soluble drugs like mirtazapine.

show abstract

Section: Introductionmentioning

confidence: 99%

Formulation Development of Mirtazapine Liquisolid Compacts: Optimization Using Central Composite Design

Naureen

Shah

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

Incorporating sodium deoxycholate endorsed the buccal administration of avanafil to heighten the bioavailability and duration of action

El-Say

Al-Hejaili

El-Sawy

et al. 2023

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Development of Liquisolid Technology to Overcome Dissolution/Absorption Limitations of Oral Drugs

Wang,

Zhang

2024

Pharmaceutical Fronts

View full text Add to dashboard Cite

Increasing influx of poorly water-soluble drugs poses a significant challenge to oral drug delivery. Conventional solubilization techniques such as solid dispersion and cyclodextrin inclusion, while capable of improving drug dissolution, suffer from a great predicament in subsequent formulation processing. A novel “powder solution technology,” the liquisolid technique, has come to the forefront in dealing with drug solubilization and formulation of oral “problem” drugs. The liquisolid technique involves the adsorption of liquid medications onto suitable carrier and coating materials, followed by conversion into free-flowing, dry-looking, and compressible powders. In the liquisolid system, the drug is dispersed in an almost molecular state, which greatly contributes to drug dissolution and absorption. This review aims to present the fundamentals of liquisolid technology and update the concept of liquisolid processing to expand its applications. The trend of modern drug discovery, drug solubilization approaches, application of liquisolid technology in formulation innovation, formulation composition, and design of liquisolid systems were discussed in detail. Special emphasis was placed on the application of liquisolid technology to improve the dissolution and bioavailability of poorly water-soluble drugs. Accumulating evidence shows that the liquisolid technology has immense potential to improve oral delivery and facilitate the secondary development of insoluble drugs.

show abstract

Clinical Pharmacokinetic Evaluation of Optimized Liquisolid Tablets as a Potential Therapy for Male Sexual Dysfunction

Cited by 4 publications

References 62 publications

Formulation Development of Mirtazapine Liquisolid Compacts: Optimization Using Central Composite Design

Formulation Development of Mirtazapine Liquisolid Compacts: Optimization Using Central Composite Design

Incorporating sodium deoxycholate endorsed the buccal administration of avanafil to heighten the bioavailability and duration of action

Development of Liquisolid Technology to Overcome Dissolution/Absorption Limitations of Oral Drugs

Contact Info

Product

Resources

About