Clinical pharmacology of antitussive agents

Bickerman, Hylan A.

doi:10.1002/cpt196233353

Cited by 19 publications

(2 citation statements)

References 14 publications

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“…It is reported that Serritus, in an early sixteenth century article on cough remedies, recommended the use of syrup of horehound to "purge through the sputa" (18). Although it has frequently been used in cough lozenges, little has been reported concerning its efficacy.…”

Section: Miscellaneous Natural Productsmentioning

confidence: 99%

“…The use of goat's milk fresh from the udder for acute and chronic cough was reported in a review of ancient Hebrew medicine (32). Galen, in the second century AD, may have been the first to report a truly effective antitussive preparation, camphorated opium tincture (18). Through the centuries, cough remedies have remained a popular item and are found in most medicine cabinets.…”

Section: Antitussivesmentioning

confidence: 99%

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Expectorants, Antitussives, and Related Agents

Paul

Dobberstein

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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Expectorants enhance the projection of respiratory tract fluid and thus facilitate the mobilization and discharge of bronchial secretions. Stimulant expectorants increase respiratory tract secretion by a direct effect on the bronchial secretory cells, and sedative expectorants act by gastric reflex stimulation. Classes of expectorants discussed include quaiacols, volatile oils, iodides and other inorganic compounds, and miscellaneous natural products. Mucolytics reduce the viscosity of tenacious and purulent mucus, thus facilitating removal. Some agents discussed that chemically depolymerize certain components of mucus include trypsin, other proteolytic enzymes, and cis ‐4‐hydroxymethyl‐2‐iodomethyl‐1,3‐dioxolane. Antitussives control excessive coughing. A brief description of the cough reflex is presented. Centrally active antitussives, both narcotic and nonnarcotic, as well as peripherally active antitussives are presented and discussed.

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Section: Miscellaneous Natural Productsmentioning

confidence: 99%

Section: Antitussivesmentioning

confidence: 99%