“…Long-term use can lead to tolerance, habituation, dependence and withdrawal syndromes. 21,45,58 Withdrawal can give rise to a syndrome that manifests as tremors, diaphoresis, photophobia, insomnia, abdominal discomfort, hypertension, and seizures. 59 Despite concerns about efficacy and substantial evidence of problematic side-effects, antipsychotics and anxiolytics are commonly administered for the calming of agitated older patients, especially when nursing shortages are acute and/or expert review is unavailable.…”