Clinical Pharmacology of Oral Cephradine

Spectroscopic, Thermal and Biological Studies of the Coordination Compounds of Sulfasalazine Drug: Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) Transition Metal Complexes

“…Antibiotics that interact with metal ions constitute a class of drugs which has been widely used in medicine both towards human beings and animals. 5,6) In particular, the interaction between transition metals and b-lactamic antibiotics such as cephalexin has been recently investigated by several physicochemical and spectroscopic methods, and with detailed biological data. [7][8][9][10] Many drugs possess modified pharmacological and toxicological properties when administered in the form of metallic complexes.…”

Fluorimetric assay of cephradine, cephalexin and cephaloglycin.

“…Although the fluorescent material is derived from hydrolysis, it is unlikely that interference will occur from metabolites of cephradine and cephalexin as they do not appear to be metabolized in man (Kirby, DeMaine & Serill, 1971;Weliky, Gadebusch, Kripalani, Amow & Schreiber, 1974;Zaki, Schreiber, Weliky, Knill & Hubsher, 1974;Brogard, Pinget, Dorner & Lavillaireix, 1975;Greene, Flannagan, Quintiliani & Nightingale, 1976;Nightingale, Greene & Quintiliani, 1976). However, cephaloglycin is deacetylated in man (Newton & Hamilton-Miller, 1967;Shimizu & Nishimura, 1970;Wick, Wright & Kuder, 1971) and possible interference of this metabolite with the assay procedure awaits investigation.…”

Synthesis, Characterization and Antibacterial Activity of a Tridentate Schiff Base Derived from Cephalexin and 1,6-Hexanediamine and its Transition Metal Complexes

“…Thus, the Schiff base ligand acts as tridentate ligand through the imine, amino and carboxylic groups. Due to their low solubility it was not possible to record satisfactory 13 C−NMR spectrum for the diamagnetic complex.…”

“…In particular, the interaction between transition metals and β-lactamic antibiotics such as cephalexin has been recently investigated [13][14][15]. Continuing with our metal-based antibiotics studies [16][17][18][19], we report herein the preparation and characterization of metal(II) coordination compounds containing a Schiff base ligand derived from the condensation of cephalexin antibiotic with 1,6-hexanediamine.…”