Clinical picture and treatment of bipolar affective disorder in children and adolescents

Cichoń, Lena; Janas–Kozik, Małgorzata; Siwiec, Andrzej; Rybakowski, Janusz

doi:10.12740/pp/onlinefirst/92740

Cited by 34 publications

(32 citation statements)

References 45 publications

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“…A recent meta-analysis showed the efficacy of typical and atypical antipsychotic agents in the treatment of mania, suggesting that disrupted signaling of DA may contribute to the presentation of manic symptoms in patients with BD [316,317]. Atypical antipsychotic agents, including olanzapine, clozapine, risperidone, quetiapine, aripiprazole, cariprazine, and ziprasidone, are classified as first-line medications for psychotic depression [314,[318][319][320][321]. They are the preferred antipsychotic agents for long-term maintenance therapy [318][319][320][321].…”

Section: Antipsychotic Agentsmentioning

confidence: 99%

Therapeutic Interventions to Mitigate Mitochondrial Dysfunction and Oxidative Stress–Induced Damage in Patients with Bipolar Disorder

Madireddy

2022

IJMS

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Bipolar disorder (BD) is characterized by mood changes, including recurrent manic, hypomanic, and depressive episodes, which may involve mixed symptoms. Despite the progress in neurobiological research, the pathophysiology of BD has not been extensively described to date. Progress in the understanding of the neurobiology driving BD could help facilitate the discovery of therapeutic targets and biomarkers for its early detection. Oxidative stress (OS), which damages biomolecules and causes mitochondrial and dopamine system dysfunctions, is a persistent finding in patients with BD. Inflammation and immune dysfunction might also play a role in BD pathophysiology. Specific nutrient supplements (nutraceuticals) may target neurobiological pathways suggested to be perturbed in BD, such as inflammation, mitochondrial dysfunction, and OS. Consequently, nutraceuticals may be used in the adjunctive treatment of BD. This paper summarizes the possible roles of OS, mitochondrial dysfunction, and immune system dysregulation in the onset of BD. It then discusses OS-mitigating strategies that may serve as therapeutic interventions for BD. It also analyzes the relationship between diet and BD as well as the use of nutritional interventions in the treatment of BD. In addition, it addresses the use of lithium therapy; novel antipsychotic agents, including clozapine, olanzapine, risperidone, cariprazine, and quetiapine; and anti-inflammatory agents to treat BD. Furthermore, it reviews the efficacy of the most used therapies for BD, such as cognitive–behavioral therapy, bright light therapy, imagery-focused cognitive therapy, and electroconvulsive therapy. A better understanding of the roles of OS, mitochondrial dysfunction, and inflammation in the pathogenesis of bipolar disorder, along with a stronger elucidation of the therapeutic functions of antioxidants, antipsychotics, anti-inflammatory agents, lithium therapy, and light therapies, may lead to improved strategies for the treatment and prevention of bipolar disorder.

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Section: Antipsychotic Agentsmentioning

confidence: 99%

Therapeutic Interventions to Mitigate Mitochondrial Dysfunction and Oxidative Stress–Induced Damage in Patients with Bipolar Disorder

Madireddy

2022

IJMS

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“…The diagnosis of borderline personality disorder should always be differentiated with other psychiatric disorders, especially with affective disorders, behaviors related to the use of psychoactive substances, anxiety disorders (especially with post-traumatic stress disorder (PTSD)), as well as schizoaffective disorders and schizophrenia, especially when violent behaviors, delusions, and incomprehensible statements are present [38].…”

Section: Discussionmentioning

confidence: 99%

“…Rozpoznanie zaburzenia osobowości typu borderline powinno być zawsze różnicowane z innymi zaburzeniami psychicznymi, przede wszystkim z zaburzeniami afektywnymi, zachowaniami związanymi z używaniem substancji psychoaktywnych, zaburzeniami lękowymi (przede wszystkim z zaburzeniami stresu pourazowego (PTSD)), a także zaburzeniami schizoafektywnymi i schizofrenią, szczególnie wtedy, gdy występują zachowania gwałtowne, urojenia i niezrozumiałe wypowiedzi [38].…”

Section: Dyskusjaunclassified

How to understand and help a person with borderline personality. Case report and literature review on the therapeutic possibilities

Sitarz

Dudek

Karakuła

et al. 2020

Current Problems of Psychiatry

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Introduction: The study aims to present 1) a case report of an 18-year-old female patient with borderline personality disorder (BPD) 2) the diagnostic and treatment difficulties in BPD patients.Materials and methods: The review of the literature from the years 1953-2020 searched from PubMed, Google Scholar, and Web of Science databases.Discussion: Patient, 18-years old, hospitalized five times for psychiatric care, presenting self-injurious behaviours, hurting herself within forearms. A patient attempted suicide eight times. She is living with her divorced parents. The patient’s father has a new partner with whom he has children. The patient used marijuana and she was experiencing psychotic symptoms under its influence. She smokes 10 cigarettes per day and drinks alcohol once a week since she was 16 years old. Psychiatric problems appeared when the patient started learning in high school.Conclusions:1. Borderline personality disorder (BPD) is a serious psychiatric condition of a difficult diagnosis that should be differentiated with many other psychiatric disorders such as an atypical or subclinical course of psychosis, affective disorders, or dissocial personality.2. A therapeutic process of a person with BPD is based on psychotherapy and personalized treatment strategies, whereas, pharmacological treatment plays only a supporting role during BPD treatment.

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“…Dotychczas nie ustalono też jednoznacznie, czy istnieją (a jeśli tak, to jak wyglądają) stany prodromalne BPD. Potwierdzono jednak występowanie przejściowych stanów psychotycznych w przebiegu choroby (Cichoń et al, 2020). Nie bez znaczenia pozostawała sytuacja rodzinna pacjenta, która w ostatnim czasie istotnie się pogorszyła (ze względu na separację rodziców i ujawnienie tajemnic).…”

Section: Omówienieunclassified

Psychotic-like experiences in conduct disorders – a case report

Szmajda¹,

Lewandowska²,

Gmitrowicz³

2020

Pediatr Med Rodz

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Psychotic symptoms in children and adolescents are an important and, at the same time, interesting issue. Current ICD-10 and DSM-5 criteria for mental disorders obviously fail to exhaust the richness of psychopathologies and to fully describe patient’s experiences. Differentiation of psychotic experiences is of particular importance in pediatric psychiatry. A number of phenomena that can be classified as psychotic either occur as a variant of normal or, as reported in studies, have no clinical significance. We describe a case of an adolescent who, with a thoughtless use of criteria, could have been easily diagnosed with schizophrenia; however, a more thorough interview and observation allowed for identification of the phenomenology of psychotic symptoms in the course of conduct disorders. The paper discusses the differential diagnosis, which allowed for the diagnosis of dissociative and conduct disorders in the described patient.

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Clinical picture and treatment of bipolar affective disorder in children and adolescents

Cited by 34 publications

References 45 publications

Therapeutic Interventions to Mitigate Mitochondrial Dysfunction and Oxidative Stress–Induced Damage in Patients with Bipolar Disorder

Therapeutic Interventions to Mitigate Mitochondrial Dysfunction and Oxidative Stress–Induced Damage in Patients with Bipolar Disorder

How to understand and help a person with borderline personality. Case report and literature review on the therapeutic possibilities

Psychotic-like experiences in conduct disorders – a case report

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