Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: A study of 133 patients diagnosed with new standard criteria

Montplaisir, Jacques; Boucher, Sylvie; Poirier, Gaétan; Lavigne, Gilles; Lapierre, O; Lespérance, Paul

doi:10.1002/mds.870120111

Cited by 850 publications

(557 citation statements)

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“…Generally, PLMS have been found in approximately 80-90% of patients with RLS (37,38) and previously, PLMS was associated with sleep disruption in MS (39). Neurophysiological examination, such as polysomnography, is essential for the diagnosis of PLMS and can contribute to diagnosis in uncertain RLS cases.…”

Section: Discussionmentioning

confidence: 95%

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Moreira

Damasceno

Medeiros

et al. 2008

Braz J Med Biol Res

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27), quality of sleep by the Pittsburgh Sleep Quality Index (PSQI >6), excessive daytime sleepiness by the Epworth Sleepiness Scale (ESS >10) and clinical disability by the Expanded Disability Status Scale (EDSS). Forty-four patients (32 women) aged 14 to 64 years (43 ± 14) with disease from 0.4 to 23 years (6.7 ± 5.9) were evaluated. Thirty-five were classified as relapsing-remitting, 5 as primary progressive and 4 as secondary progressive. EDSS varied from 0 to 8.0 (3.6 ± 2.0). RLS was detected in 12 cases (27%). Patients with RLS presented greater disability (P = 0.01), poorer sleep (P = 0.02) and greater levels of fatigue (P = 0.03). Impaired sleep was present in 23 (52%) and excessive daytime sleepiness in 3 cases (6.8%). Fatigue was present in 32 subjects (73%) and was associated with clinical disability (P = 0.000) and sleep quality (P = 0.002). Age, gender, disease duration, MS pattern, excessive daytime sleepiness and the presence of upper motor neuron signs were not associated with the presence of RLS. Fatigue was best explained by clinical disability and poor sleep quality. Awareness of RLS among health care professionals may contribute to improvement in MS management.]]>

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Section: Discussionmentioning

confidence: 95%

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Moreira

Damasceno

Medeiros

et al. 2008

Braz J Med Biol Res

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“…However, idiopathic RLS itself has not been shown to be a risk factor for cardiovascular morbidity [40,41] unless perhaps when duration of RLS symptoms is taken into account [17]. It is well known that patients with RLS (either secondary or idiopathic) also experience increased leg movement activity during the night, known as periodic limb movements in sleep (PLMS), which is reportedly present in 80% of cases [42,43]. PLMS severity was reported to be associated with high mortality in patients with end-stage renal disease [44].…”

Section: Page 12 Of 35mentioning

confidence: 99%

Restless legs syndrome does not affect 3-year mortality in hemodialysis patients

et al. 2015

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Original Highlights of the studyWe evaluated the relationship of RLS and mortality in chronic hemodialysis patients For the diagnosis of RLS we implemented standard methodology, i.e. the essential clinical criteria of the International RLS Study Group. This is the first time this issue is investigated in an epidemiological survey in Greece.In contrast to previous reports the diagnosis of RLS does not influence the 3-year mortality in HD patients. ABSTRACTObjective: In chronic hemodialysis (HD) patients, the prevalence of restless legs syndrome (RLS) is significantly higher than in the general population. Uremic RLS has been related to an enhanced mortality of HD patients. In the general population, however, studies of this association have yielded inconsistent results. The aim of the present study was to re-evaluate the relationship of RLS and mortality in HD patients. Methods:We recorded the 3-year mortality rate in a population of 579 HD patients after assessment for RLS symptoms. In addition we analyzed the 5-year mortality rate after end-stage renal disease onset (i.e., commencement of HD). This HD patient population has been previously included in a cross-sectional survey of RLS prevalence in which RLS diagnosis was based on the essential clinical criteria of the International RLS Study Group. Mortality data were acquired from the national endstage renal disease registry. Survival probability was calculated by means of the Kaplan-Meier method and analyzed by the log-rank (Mantel-Cox) test. For multivariate survival analysis, we implemented a proportional hazards regression Conclusion: Diagnosis of RLS according to the essential clinical criteria of theInternational RLS Study Group does not seem to influence the 3-year mortality in HD patients. Our findings are in contrast to those in some previous reports, and reinforce the need for further studies of RLS and mortality in HD patients.

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“…Therefore, the PSG is not necessary for diagnosis. However, in situations where the clinical diagnosis is doubtful, the PSG provides additional resources, since about 80% of RLS patients have PLMS 32 . The PLMs are described as rhythmic hallux extensions with the heel dorsiflexion and occasional bending of the knee and hip joint, occurring during sleep or wakefulness, with a tendency to concentrate during NREM sleep, in series at regular intervals.…”

Section: Role Of the Psg Test In The Evaluation Of Rlsmentioning

confidence: 99%