Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Moreira, Nuno Canto; Damasceno, Roniel Sousa; Medeiros, Caroline Addison Carvalho Xavier de; Bruin, Pedro Felipe Carvalhedo de; Teixeira, Cláudia Fernanda Almeida; Horta, Wagner G.; Bruin, Veralice Meireles Sales de

doi:10.1590/s0100-879x2008001000017

Cited by 99 publications

(89 citation statements)

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“…The association of RLS and multiple sclerosis (MS) has been so consistent that it has recently been suggested that MS should be another recognized secondary cause for RLS 2 . During the last decade, a few studies [2][3][4][5][6] have suggested that the association of these two neurological conditions seems to be more than fortuitous. However, not all authors have agreed with this hypothesis 7 , which left the matter still open to discussion.…”

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confidence: 99%

Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature

Fragoso

Finkelsztejn

Gomes

et al. 2011

Arq. Neuro-Psiquiatr.

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Objective: The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and meta-analysis of the literature was carried out on the subject of RLS-MS. Method: MS patients and controls were investigated regarding the presence of the four typical symptoms of RLS. A questionnaire assessing RLS severity was also used for patients and controls presenting the four RLS symptoms criteria. The systematic review and meta-analysis on the subject were carried out according to the strict international criteria. Results: In the present report, the RLS-MS association was confirmed as being more than fortuitous in Brazilian MS patients, in a multicenter casecontrol study. MS patients also presented RLS symptoms of greater severity than did the control population. A systematic review and meta-analysis of the literature showed that MS patients had a fourfold higher chance of presenting RLS than did the controls. Conclusion: Although underlying mechanisms to explain the association RLS-MS are still a matter of discussion, there is a clear association of these two neurological conditions. Key words: multiple sclerosis, restless legs syndrome, meta-analysis.Síndrome das pernas inquietas e esclerose múltipla: um estudo brasileiro multicên trico e metanálise da literatura RESUMO Objetivo: A maior prevalência de síndrome das pernas inquietas (SPI) em esclerose múltipla (EM) foi recentemente assunto de algumas publicações. O presente trabalho investigou a prevalência de sintomas de SPI em pacientes com EM e em controles em quatro cidades brasileiras. Além disto, uma revisão sistemática da literatura e metanálise dos dados foi feita considerando o tema SPI-EM. Método: Pacientes com EM e controles foram investigados com relação aos quarto sintomas típicos de SPI. Um questionário avaliando a intensidade da SPI também foi utilizado para pacientes e controles que apresentassem os quatro sintomas para critério diagnóstico de SPI. A revisão sistemática e meta-análise do tema foram realizadas de acordo com os rígidos critérios internacionais. Resultados: No presente estudo, a associação de SPI-EM foi confirmada como sendo mais que coincidência nos pacientes brasileiros com EM, através do estudo caso-controle multicêntrico. Os pacientes com EM também apresentaram maior gravidade dos sintomas de SPI que os controles. A revisão sistemática e metanálise da literatura mostraram que os pacientes com EM tiveram quatro vezes mais chance de apresentar SPI do que controles. Conclusão: Embora os mecanismos envolvidos na associação SPI-EM ainda sejam motivo de discussão, existe uma clara associação entre estas duas condições neurológicas. Palavras-chave: esclerose múltipla, síndrome das pernas inquietas, metanálise. Correspondence Yára Dadalti Fragoso

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confidence: 99%

Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature

Fragoso

Finkelsztejn

Gomes

et al. 2011

Arq. Neuro-Psiquiatr.

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“…Among the patients with MS, 71 (78%) had relapsingremitting MS (RRMS), 8 (8.8%) had secondary progressive MS (SPMS), 3 (3.3%) had progressive relapsing MS (PRMS), and 9 (9.9%) had primary progressive MS (PPMS). The median number of attacks was 3 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and the median EDSS score was 3 (0-9) in the MS group (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…RLS symptoms appear usually after the onset of MS (18)(19)(20)23,26,27). There is no relationship between MS subtypes and the presence of RLS (18,20,(22)(23)(24)(25)31). There are only three studies that investigated the relationship between functional system involvement and the presence of RLS in MS patients (19,23,25).…”

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Restless legs syndrome in multiple sclerosis

Sorgun¹,

Aksun²,

Atalay³

et al. 2015

Turk J Med Sci

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IntroductionRestless legs syndrome (RLS) is a sleep disorder characterized by an urge to move the legs associated with uncomfortable paresthesias. Usually, the symptoms manifest in the evening or at night, when the patients take rest, and are relieved by walking or moving the legs (1). Diagnosis of RLS needs to involve the following clinical features: (a) uncomfortable and unpleasant sensations in the legs, (b) worsening of the symptoms during rest, (c) relief of the symptoms by movement, (d) exacerbation of the sensitive disturbance in the evening or at night (1). The majority of RLS cases are commonly classified as idiopathic and include sporadic and inherited forms. Secondary form of RLS has been associated with iron deficiency, renal failure, pregnancy, antidopaminergic therapy, rheumatoid arthritis, or several neurological disorders, including peripheral neuropathy, spinocerebellar ataxia, essential tremor, Parkinson disease, and myelopathies (2-4). The etiopathogenesis of RLS is unknown, yet there is increasing evidence of dopaminergic neurotransmission dysfunction (5-9).RLS prevalence has been reported to be 1.2%-15% and 12.12%-65.1% in the general population and in MS patients, respectively (10-30). RLS symptoms appear usually after the onset of 23,26,27). There is no relationship between MS subtypes and the presence of RLS (18,20,[22][23][24][25]31). There are only three studies that investigated the relationship between functional system involvement and the presence of RLS in MS patients (19,23,25). Two of them showed that there was a significant relationship between some functional system involvement and RLS (19,25). In contrast, Deriu et al. did not find any relationship between the presence of RLS and functional system involvement (23). Some studies suggested that the expanded disability status scale (EDSS) was not related to RLS in MS patients (22,23). However, other studies showed that EDSS score was higher in MS patients with RLS than in those without RLS (18)(19)(20)30).Lesion localization in brain MRI did not show any relationship with the presence of RLS in MS patients in most studies (18)(19)(20)22,23). There is only one study showing that MS patients with RLS (MS/RLS+) and patients without RLS (MS/RLS-) had similar cervical cord lesion load, but with less fractional anisotropy in cervical and brain MRI in the latter.Background/aim: There have been conflicting results in the literature regarding the relationship between functional system involvement, the expanded disability status scale (EDSS), and the presence of restless legs syndrome (RLS) in patients with multiple sclerosis (MS).Materials and methods: Ninety-one patients with MS and 40 patients in a control group (headache, essential tremor, and benign positional paroxysmal vertigo) were studied. The patients underwent a complete neurological examination and Kurtzke functional system scores were calculated. In order to assess the temporal relation between the onset of RLS and MS, a semistructured interview guided by a questionnaire about R...

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“…Families MS results in many physical, 12 cognitive, 13 economic, 14 psychosocial, 10 and emotional 15 setbacks that inevitably transform the lives of affected patients as well as their families. Physical problems include chronic pain, 16 decreased mobility, 17 fatigue or weakness, 18,19 bowel dysfunction, 20 and sexual dysfunction. 21 Examples of cognitive deficits include memory problems, 22 language comprehension and fluency problems, 23 and attention deficits.…”

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confidence: 99%