Clinical Predictors of Excessive Daytime Sleepiness in Patients with Parkinson's Disease

Junho, Bruno Terra; Kümmer, Arthur; Cardoso, Francisco; Teixeira, Antônio Lúcio; Rocha, Natália Pessoa

doi:10.3988/jcn.2018.14.4.530

Cited by 18 publications

(15 citation statements)

References 53 publications

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“…Factors associated with formal ID diagnosis in PD have received little attention. Nevertheless, similar to the general population, age, female gender, medical comorbidities, poor quality of life, anxiety, symptoms of depression, fatigue, and daytime sleepiness have been associated with insomnia complaint severity in PD (Chung et al, ; Gjerstad, Wentzel‐Larsen, Aarsland, & Larsen, ; Junho, Kummer, Cardoso, Teixeira, & Rocha, ; Kurtis, Rodriguez‐Blazquez, & Martinez‐Martin, ; Ratti et al, ; Tholfsen, Larsen, Schulz, Tysnes, & Gjerstad, ; Zoccolella et al, ). In contrast, clinical features of the disease (i.e.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

et al. 2019

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Objective To test the efficacy of cognitive behavioral therapy for insomnia (CBT‐i) in Parkinson's Disease (PD) and to evaluate its impact on indices of daytime and psychological functioning. Method Fifteen patients with insomnia disorder (ID) comorbid to PD were enrolled in a single‐case design with multiple baselines. Total wake time, sleep efficiency, and daytime sleepiness were recorded on a sleep diary. Self‐reported measures of insomnia, anxiety and depressive symptoms, health‐related quality of life, and psychological variables perpetuating ID were completed. All patients also underwent a clinical interview for ID diagnosis. Results CBT‐i was associated with significant changes in sleep variables and ID criteria. Significant positive treatment‐related effects were also noted for all indices of daytime and psychological functioning, and for variables perpetuating ID. All of these improvements were well maintained at 3‐month follow‐up. Conclusion CBT‐i is a promising therapeutic avenue for patients with PD.

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Section: Introductionmentioning

confidence: 99%

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

et al. 2019

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“…Recent polysomnography studies by Lee et al have found an association between depression and insomnia [24], and an association between depression and restless legs syndrome has also been found in other studies [25][26][27]. Depression has been shown to be a risk factor for excessive daytime sleepiness [28,29]. Christopher et al demonstrated that nightmares were significantly associated with depressive symptoms [30], although this needs to be confirmed using polysomnography.…”

Section: Discussionmentioning

confidence: 93%

Risk factors for sleep disorders in patients undergoing peritoneal dialysis

Liu

Zhan

Zhao

et al. 2021

Sleep Biol. Rhythms

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Sleep disorders in patients with end-stage renal disease are common but have rarely been reported in previous studies. Therefore, we examined the prevalence of sleep disorders and the risk factors for declining sleep quality in patients undergoing peritoneal dialysis (PD). A multicenter prospective cohort study was conducted at five PD centers across different provinces in China. A total of 449 patients who underwent PD between March to November 2013 were enrolled. Demographic data, laboratory indicators, presence of depression, and sleep assessment data were collected. Sleep questionnaires reflecting five categories of sleep disorders, namely, insomnia, restless legs syndrome, excessive daytime sleepiness, possible narcolepsy, and sleepwalking and nightmares, were administered at baseline and at 24 months postoperatively. Sleep disorders were diagnosed when a patient had at least one sleep problem. At baseline, 335 (74.6%) patients had at least one type of sleep disorder. Depression, diabetes mellitus (DM), and male were found to be associated with the presence of a sleep disorder. At follow-up, the prevalence of insomnia, restless legs syndrome, and excessive daytime sleepiness had significantly increased in 285 patients. Furthermore, cardiovascular disease (CVD) was found to be associated with the presence of sleep disorders in patients with one or more disorders at baseline, whereas a low serum albumin level was found to be associated with sleep disorders in patients without any sleep disorders at baseline. The prevalence of sleep disorders was relatively high among PD patients at baseline and increased afterthe2-year follow-up. Depression, DM, and male were associated with all sleep disorders at baseline. CVD was associated with the presence of a sleep disorder at baseline and worse sleep quality at the 2-year follow-up; whereas a low serum albumin level was associated with the risk of acquiring a sleep disorder at the 2-year follow-up among patients with normal sleep status at baseline.

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“…EDS was known as one of the most frequent sleep disorders in PD. Usually, male gender, older age, nighttime sleep problems, and dopaminergic agonist usage were related to increased risk of EDS in PD (26,27). However, there were other studies indicating that apart from dopaminergic agonist, larger levodopa dosage was more significantly associated with EDS (26,28,29).…”

Section: Discussionmentioning

confidence: 98%

Quality of Life in Newly Diagnosed Patients With Parkin-Related Parkinson's Disease

et al. 2020

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Introduction: Mutations in the Parkin gene are the most common cause of autosomal recessive early-onset Parkinson's disease (PD). However, little is known about the quality of life (QoL) in Parkin-related PD. Here, we investigated the patterns of QoL in newly diagnosed Parkin-related PD patients.Methods: Newly diagnosed PD patients (diagnosis made within 12 months) who had an age of onset (AOO) below 40 and underwent a PD-related genetic testing, were recruited (n = 148). Among them, 24 patients carried bi-allelic variants in Parkin (PD-Parkin) and 24 patients did not have any known causative PD mutations, or risk variants (GU-EOPD). The clinical materials, relevant factors and determinants of QoL were analyzed.Results: PD-Parkin patients had a younger AOO (p = 0.003) and longer disease duration (p = 0.005). After adjustment for AOO and disease duration, more dystonia (p = 0.034), and worse scores of non-motor symptoms including Beck depression inventory (BDI, p = 0.035), Epworth sleepiness scale (ESS, p = 0.044), and subdomains of depression/anxiety (p = 0.015) and sleep disorders (p = 0.005) in Non-motor symptoms questionnaire, were found in PD-Parkin comparing with GU-EOPD. PD-Parkin patients had poorer QoL (adjusted p = 0.045), especially in the mobility (adjusted p = 0.025), emotional well-being (adjusted p = 0.015) and bodily discomfort dimensions (adjusted p = 0.016). BDI scores (p = 0.005) and ESS scores (p = 0.047) were significant determinants of QoL in PD-Parkin.Conclusion: Newly diagnosed PD-Parkin patients showed worse QoL. More depression and excessive daytime sleepiness predicted worse QoL. For clinicians, management of depression and excessive daytime sleepiness is suggested to better improve QoL in patients with Parkin mutations.

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Clinical Predictors of Excessive Daytime Sleepiness in Patients with Parkinson's Disease

Cited by 18 publications

References 53 publications

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

Risk factors for sleep disorders in patients undergoing peritoneal dialysis

Quality of Life in Newly Diagnosed Patients With Parkin-Related Parkinson's Disease

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