Clinical predictors of malignancy in patients diagnosed with atypical ductal hyperplasia on vacuum-assisted core needle biopsy.

Hodorowicz-Zaniewska, Diana; Brzuszkiewicz, Karolina; Szpor, Joanna; Kibil, Wojciech; Matyja, Andrzej; Dyląg-Trojanowska, Katarzyna; Richter, Piotr; Szczepanik, Antoni M.

doi:10.5114/wiitm.2018.73528

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…The significant difference in the convergence of mammography and ultrasound results for BI-RADS scores of 4 and 5 in the literature and this study are probably due to the use of non-uniform, conservative and subjective criteria for qualifying breast tumours to particular BI-RADS categories, both in mammography and in ultrasound performed in the Population-based Breast Cancer Early Detection Screening Programme. A study by Hodorowicz-Zaniewska et al [7] showed no difference…”

Section: Discussionmentioning

confidence: 88%

“…In the current study, breast cancer was significantly more frequently diagnosed in the biopsy material in women aged 56 69 (p<0.001). Hodorowicz-Zaniewska et al [7] also showed that the mean age of women with malignant breast lesions was 56.8±13.02. On the other hand, the results of the study by Dobruch-Sobczak [8] differed from the above -the mean age of patients with diagnosed breast cancer was lower and amounted to 55.07.…”

Section: Discussionmentioning

confidence: 91%

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Analysis of diagnostic methods of a population-based breast cancer early detection screening programme

Szymoniak¹,

Pytel²,

Malinowski³

et al. 2021

Med Og Nauk Zdr.

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Introduction and objective.Breast cancer is the most common malignant tumour in women in Poland. In 2006, the Population-based Breast Cancer Early Detection Screening Programme was introduced in Poland to decrease the mortality of women due to this cancer. This study aimed to analyse the diagnostic methods used in the Population-based Breast Cancer Early Detection Screening Programme in the experience of one facility in Poland. Materials and method. The material for the study consisted of 1,411 questionnaires from women aged 50-69 qualified for enhanced diagnostics by a mammography performed in the first stage of the programme. During the study, a retrospective analysis of the documentation was performed. Results. Analysis of the convergence of BI-RADS scores between MMG and USG showed that the highest convergence was confirmed for a BI-RADS score of 4 and the lowest for a BI-RADS score of 5. Comparing the sensitivity and specificity of MMG and USG after the acquisition of BI-RADS, BAC were more frequently chosen for enhanced diagnostics of breast cancer. However, cancer was significantly more often confirmed by BAG. Tumours were biopsied more frequently for BI-RADS scores of 4 and 5 in both MMG and USG. Core-needle biopsy was more frequently used to diagnose a BI-RADS score of 5 tumours in both MMG and USG. In contrast, fine-needle biopsy was more frequently used to diagnose BI-RADS scores of 3, 0 and 4 in mammography. Conclusions. The obtained results showed the highest sensitivity of breast cancer screening methods for BI-RADS MMG (4+5) and ultrasound (3+4+5). The highest convergence of results between MMG and USG is shown for a BI-RADS score of 4. Breast tumours are more often diagnosed by BAC, but cancer is more often confirmed by BAG.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 91%

Analysis of diagnostic methods of a population-based breast cancer early detection screening programme

Szymoniak¹,

Pytel²,

Malinowski³

et al. 2021

Med Og Nauk Zdr.

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“… 2 Precancerous lesion (PL) refers to a lesion with a certain degree of atypical hyperplasia in histomorphology and the potential for canceration. 3 , 4 According to WHO, all kinds of lesions with more than 20% possibility of canceration belong to PL. 5 Breast precancerous lesions refer to a certain degree of morphological atypical hyperplasia of breast duct epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

Based on BATMAN-TCM to Explore the Molecular Mechanism of Xihuang Pill Regulating Immune Function to Treat Breast Precancerous Lesions

Li¹,

Fan²,

Dong³

et al. 2021

BCTT

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Objective:The specific mechanism of Xihuang Pill in the treatment of breast precancerous lesions and breast cancer has not yet been elucidated. Methods: In our study, BATMAN-TCM (a Bioinformatics Analysis Tool for Molecular mechanisms of Traditional Chinese Medicine) was used to forecast the relationship among chemical components, immune targets, and diseases of each herb in Xihuang Pill and constructed a component-target-disease network. Taking breast precancerous lesion model rats as the research object, the molecular mechanism of Xihuang Pill regulating immunity was analyzed. Results: BATMAN-TCM prediction showed that 309 genes were enriched in the biological process of "immune system response", which was the target of Xihuang Pill to regulate the immune system. The target of breast cancer disease and the genes related to Xihuang Pill's immune system response were crossed, and 88 cross genes were obtained. According to the enrichment results of GO/KEGG pathway, T cell activation was found to be the most relevant. We select Th1 cells (IL-2, IFN-γ) and Th2 cells (IL-4, IL-10) among them for animal experiment verification. The results show that Xihuang Pill can upregulate the serum IFN-γ and IL-2 levels, reduce the IL-4 and IL-10 levels, and regulate the balance of Th1/Th2 cells in the peripheral blood of rats with breast precancerous lesions. Conclusion: Xihuang Pill targets a variety of immune-related molecules related to breast precancerous lesions and is a traditional Chinese medicine formula that effectively regulates immune function.

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“…The ultrasound (US) features such as margin, size of the lesions, and echogenicity features, are vital for the detection and discrimination of benign and malignant lesions ( 15 ), and also help in prediction of axillary lymph node metastasis in breast cancer ( 16 ). US has been widely used in imaging-guided breast CNB, especially in developing countries, with the advantage of real-time visualization, less expensive, not using ionizing radiation, and not limited to breast density ( 15 , 17 ). However, only a limited number of studies have investigated the use of US features for predicting the upgrade of ADH ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Simple-to-Use Nomogram for Predicting the Upgrade of Atypical Ductal Hyperplasia on Core Needle Biopsy in Ultrasound-Detected Breast Lesions

Huang

Chen

et al. 2021

Front. Oncol.

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BackgroundThe rate of carcinoma upgrade for atypical ductal hyperplasia (ADH) diagnosed on core needle biopsy (CNB) is variable on open excision. The purpose of the present study was to develop and validate a simple-to-use nomogram for predicting the upgrade of ADH diagnosed with ultrasound (US)-guided core needle biopsy in patients with US-detected breast lesions.MethodsTwo retrospective sets, the training set (n = 401) and the validation set (n = 186), from Fudan University Shanghai Cancer Center between January 2014 and December 2019 were retrospectively analyzed. Clinicopathological and US features were selected using univariate and multivariable logistic regression, and the significant features were incorporated to build a nomogram model. Model discrimination and calibration were assessed in the training set and validation set.ResultsOf the 587 ADH biopsies, 67.7% (training set: 267/401, 66.6%; validation set: 128/186, 68.8%) were upgraded to cancers. In the multivariable analysis, the risk factors were age [odds ratio (OR) 2.739, 95% confidence interval (CI): 1.525–5.672], mass palpation (OR 3.008, 95% CI: 1.624–5.672), calcifications on US (OR 4.752, 95% CI: 2.569–9.276), ADH extent (OR 3.150, 95% CI: 1.951–5.155), and suspected malignancy (OR 4.162, CI: 2.289–7.980). The model showed good discrimination, with an area under curve (AUC) of 0.783 (95% CI: 0.736–0.831), and good calibration (p = 0.543). The application of the nomogram in the validation set still had good discrimination (AUC = 0.753, 95% CI: 0.666–0.841) and calibration (p = 0.565). Instead of surgical excision of all ADHs, if those categorized with the model to be at low risk for upgrade were surveillanced and the remainder were excised, then 63.7% (37/58) of surgeries of benign lesions could have been avoided and 78.1% (100/128) malignant lesions could be treated in time.ConclusionsThis study developed a simple-to-use nomogram by incorporating clinicopathological and US features with the overarching goal of predicting the probability of upgrade in women with ADH. The nomogram could be expected to decrease unnecessary surgery by nearly two-third and to identify most of the malignant lesions, helping guide clinical decision making with regard to surveillance versus surgical excision of ADH lesions.

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Clinical predictors of malignancy in patients diagnosed with atypical ductal hyperplasia on vacuum-assisted core needle biopsy.

Cited by 4 publications

References 35 publications

Analysis of diagnostic methods of a population-based breast cancer early detection screening programme

Analysis of diagnostic methods of a population-based breast cancer early detection screening programme

Based on BATMAN-TCM to Explore the Molecular Mechanism of Xihuang Pill Regulating Immune Function to Treat Breast Precancerous Lesions

Development and Validation of a Simple-to-Use Nomogram for Predicting the Upgrade of Atypical Ductal Hyperplasia on Core Needle Biopsy in Ultrasound-Detected Breast Lesions

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