2013
DOI: 10.1002/cncr.28102
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Clinical predictors of survival in men with castration‐resistant prostate cancer

Abstract: BACKGROUND: This study sought to characterize Modern patients with castration-resistant prostate cancer (CRPC) and identify pretreatment clinical predictors of survival. METHODS: A cohort of men with CRPC with and without metastases (M) treated with secondary hormonal therapy (2eHT) and/or chemotherapy (CT) was identified from the authors' institutional database. Associations of patient and disease characteristics at diagnosis, at androgen-deprivation therapy (ADT) initiation, at CRPC index date, and survival … Show more

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Cited by 39 publications
(16 citation statements)
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“…Historically, a diagnosis of Gleason score 6 cancer was not as predictive of good behavior, with a higher rate of progression and some men even dying of PCa [17,19]. In the current study, Gleason score 6 cancer at RP has a 96% cure rate at 5 yr, even including cases with extraprostatic extension and positive margins.…”
Section: Discussionmentioning
confidence: 51%
“…Historically, a diagnosis of Gleason score 6 cancer was not as predictive of good behavior, with a higher rate of progression and some men even dying of PCa [17,19]. In the current study, Gleason score 6 cancer at RP has a 96% cure rate at 5 yr, even including cases with extraprostatic extension and positive margins.…”
Section: Discussionmentioning
confidence: 51%
“…Поиск факторов прогноза показал значимое вли-яние на ОВ таких факторов, как наличие болевого синдрома, статус по шкале ECOG 2, уровень ПСА ≥ 288 нг/мл, ЛДГ ≥ 450 Ед/л, ЩФ ≥ 250 Ед/л, кальция < 2,28 ммоль/л и гемоглобина < 11,5 г/дл, а также дли-тельность ответа на ГТ < 24 мес. Полученные резуль-таты коррелируют с данными других исследований [8][9][10][11][12]. Следует заметить, что такой параметр, как на-личие висцеральных метастазов, не включенный в многофакторный анализ ввиду малого числа таких пациентов на момент начала лечения мКРРПЖ, без-условно также является значимым с клинической точки зрения.…”
Section: Discussionunclassified
“…46,47 Historically, a diagnosis of Gleason score 6 cancer was not as predictive of good behavior, with a higher rate of progression and some men even dying of prostate cancer. 47,48 Currently, it is recommended that all cribriform glands be considered as Gleason pattern 4. Ill-defined glands with poorly formed glandular lumina were not discussed or depicted by Gleason as either Gleason pattern 3 or 4.…”
Section: Updated International Society Of Urologic Pathology Grading mentioning
confidence: 99%