Clinical Presentation and Outcome of Bacterial Meningitis in University Hospital

Abstract

Purpose: To determine the clinical characteristics and outcome of bacterial meningitis in adult patients using CT, MRI and CSF culture. Methods: Patients admitted to the university hospital with clinical diagnosis of meningitis were included in the present study. All patients were subjected to clinical examination as well as CT, MRI scanning and CSF-bacteriological culture. Results: The age distribution of the patients shows that there is high frequency of symptoms found in the age group between ages 40 -45. CSF in the present study included WBS, RBC, glucose and protein, which is associated with the adverse outcome. Meningitis can be confirmed by many methods, in the present study three different methods were used, which included CT scan, MRI and CSF analysis and bacterial culture. In CT scan, among the predictors of meningitis, persons with TB (P = 0.037), patients with HIV (P = 0.036) and stroke (P = 0.036) showed significant association. Whereas MRI findings were significantly associated with TB meningitis (P = 0.015). Meningitis was prevalent in the age group of <45. Conclusion: This study highlights the importance of several modalities for diagnosing and predicting the outcome of meningitis in adults.

Antimicrobial sensitivity profile and bacterial isolates among suspected pyogenic meningitis patients attending at Hawassa University Hospital: Cross-sectional study

“…The predominant organism in our study was found to be N. meningitidis. However, in agreement findings were reported from other studies from Nigeria [41] and Iran [39] indicating that E. coli was the predominant bacteria next to S. pneumoniae. In another study from a systematic review and metaanalysis conducted in different regions of Europe [28], Haemophilus influenzae accounted (35.5%), was the predominant organism next to Streptococcus pneumoniae (19.6%) and other pathogens (12%).…”

“…The most common clinical presentation in the current study was fever 330(83.8%), headache 205(52.1%) and neck stiffness 179(45.4) followed by altered mental status upon arrival 125(31.6%). Inconsistent findings to this study were also reported from Saudi Arabia fever (80%) altered mental status (70.0%) followed by neck rigidity (41.7%) [39]. This difference could be due to the difference in clinician management, geographical area or difference in the guideline used in meningitis management.…”

Spectrum of central nervous system infections in a tertiary health care centre in Cameroon

“…Clinical manifestations are often similar to those of classical data [ 4 ]. In this study, the neurological signs were mainly: headache, impaired consciousness, meningeal syndrome, and seizures.…”

“…Central nervous system (CNS) infections are potentially life-threatening conditions that constitute a diagnostic and therapeutic emergency [ 1 – 5 ]. It is a group of neurological conditions with varying symptoms depending on the type of infection, the pathogen involved and the site in which they occur [ 4 , 6 ]. These infections are caused by microorganisms (viruses, bacteria, fungi, protozoa); macro-organisms and microparticles (prions) [ 3 , 6 – 8 ].…”