Clinical presentation and risk factors of placental abruption

Tikkanen, Minna; Nuutila, Mika; Hiilesmaa, Vilho; Paavonen, Jorma; Ylikorkala, Olavi

doi:10.1080/00016340500449915

Cited by 149 publications

(147 citation statements)

References 25 publications

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“…Correlation of placental abruption with both chronic hypertension and preeclampsia has been clearly established (8,(16)(17)(18)(19). Similarly, in our study an association of both chronic hypertension and preeclampsia with abruption was seen, consistent with the literature (p<0.05).…”

Section: Discussionsupporting

confidence: 82%

Risk Factors and Outcomes of Placental Abruption: Evaluation of 53 Cases

Budak¹,

Şentürk²,

Çakmak³

et al. 2018

Haseki

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Plasenta Dekolmanının Risk Faktörleri ve Sonuçları: Elli Üç Olgunun DeğerlendirmesiAim: The aim of this study was to evaluate the risk factors and maternal-perinatal outcomes of placental abruption in a non-tertiary center.Methods:Fifty-three cases with placental abruption and 147 cases of non-placental abruption were compared retrospectively. Age, gravida, parity, concomitant medical problems (preeclampsia, hypertension, and diabetes), previous cesarean rate and proteinuria rate were compared between groups. Multiple regression analysis was performed to determine risk factors for placental abruption. A p value under 0.05 was considered as meaningful.Results: Prematurity, need for intensive care unit for the newborn, peripartum mortality and low Apgar score were higher in the group with placental abruption (p<0.05). Preeclampsia, duration in the hospital, complications (especially disseminate intravascular coagulation), proteinuria and blood product transfusion rate was higher in the placental abruption group (p<0.05). Previous cesarean, preeclampsia, concomitant medical problems and proteinuria were risk factors for placental abruption (p<0.05). Conclusion:Pregnancy related hypertensive disorders and previous cesarean increase the risk of placental abruption. Placental abruption is associated with serious maternal and perinatal morbidity. Keywords: Complications, morbidity, perinatal morbidities, placental abruptionAmaç: Bu çalışmanın amacı non-tersiyer bir merkezdeki plasental dekolman olgularını inceleyerek risk faktörleri ile maternal ve perinatal sonuçları araştırmaktır.Yöntemler: Retrospektif olarak 53 olgu ile plasental dekolman olmayan 147 olgu incelendi. Yaş, gravida, parite, eşlik eden medikal durumlar (preeklampsi, hipertansiyon, diabetes mellitus), önceki sezeryan öyküsü, proteinüri oranları iki grup arasında karşılşatırıldı. Yine maternal ve perinatal sonuçlar iki grup arasında karşılşatırıldı. Multipl regresayon analizi ile risk faktörleri araştırıldı. İstatistiksel olrak p değerinin 0,05 altında olması anlamlı kabul edildi. Bulgular: Plasental dekolman olan grupta prematürite, yenidoğan yoğun bakım ihtiyacı, peripartum mortalite ve düşük apgar skoru oranı daha fazla idi (p<0,05). Yine dekolman olan grupta eski sezeryan oranı, preeklampsi, hastanede yatış süresi, özellikle dissemine intravasküler koagülopati başta olmak üzere komplikasyon oranları, idararda proteinüri oranı ile transfüzyon oranları daha fazla idi (p<0,05). Eski sezaryen olması, preeklampsi ve ek morbiditenin olması ile proteinüri varlığı preeklampsi riskini artırmaktadır (p<0,05). Sonuç:Gebeliğin hipertansif hastalıkları ve eski sezeryanlı olmak plasental dekolman riskini artırmaktadır. Plasenta dekolmanı ciddi perinatal ve maternal morbidite ile ilişkilidir.

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Section: Discussionsupporting

confidence: 82%

Risk Factors and Outcomes of Placental Abruption: Evaluation of 53 Cases

Budak¹,

Şentürk²,

Çakmak³

et al. 2018

Haseki

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“…Undoubtedly, smoking during preg- nancy may be detrimental to both maternal and fetal health. Smoking is associated with preterm birth and preterm premature rupture of membranes (PPROM), placenta abruption, placenta previa-accreta, intrauterine fetal growth retardation, and sudden infant death syndrome (32)(33)(34)(35)(36). Despite the adverse effects of smoking on maternal-fetal health, numerous studies demonstrate that smoking is protective against PIH (1-6).…”

Section: Discussionmentioning

confidence: 99%

Nicotine Inhibits Cytokine Production by Placenta Cells via NFκB: Potential Role in Pregnancy-Induced Hypertension

Dowling

Rochelson

Way

et al. 2007

Mol Med

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“…The arterioles rupture and separation of the placenta occur. Placental biopsies after abruption show the same abnormal vascular structures as in preeclampsia (33).…”

Section: Tab 1: Incidence Of Hereditary Thrombophilia In the Generalmentioning

confidence: 56%

Factor V Leiden Mutation and its Impact on Pregnancy Complications

Hammerova

Chabada

Drobny

et al. 2011

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary:Objective: The aim of this prospective study was to find the association between the factor V Leiden mutation and adverse pregnancy outcomes. Methods: This study is an analysis of a prospective observational study of the frequency of placenta-mediated complications of factor V Leiden mutation carriers. We compared pregnancy outcomes of 11 women with a heterozygous form of the factor V Leiden mutation with 41 women of a control group. Results: All pregnancies ended with delivery of a living infant. None of the 52 pregnancies were complicated by venous thromboembolism. There were a few significant differences regarding placenta-mediated complications. The gestational age at delivery showed small significant differences. There was a significant difference in the birth weight deviation in percentage between FVL carriers and controls. The incidence of blood loss exceeding 1000 ml was higher in the control group. Conclusions: Carriership of the factor V Leiden mutation did not affect the incidence of preeclampsia. Adverse pregnancy outcomes such as placental abruption were rare. Eclampsia, intrauterine fetal death and venous thromboembolism did not occur. Our results provide evidence that the maternal heterozygous FVL mutation did not increase the risk of an adverse pregnancy outcome.

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Clinical presentation and risk factors of placental abruption

Cited by 149 publications

References 25 publications

Risk Factors and Outcomes of Placental Abruption: Evaluation of 53 Cases

Risk Factors and Outcomes of Placental Abruption: Evaluation of 53 Cases

Nicotine Inhibits Cytokine Production by Placenta Cells via NFκB: Potential Role in Pregnancy-Induced Hypertension

Factor V Leiden Mutation and its Impact on Pregnancy Complications

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