Clinical Presentation, Histological Findings and Prevalence of &lt;i&gt;Helicobacter pylori&lt;/i&gt; in Patients of Gastric Carcinoma

Kabir, M A; Barua, Rajib; Masud, Hasan; Ahmed, Dewan Saifuddin; Islam, Muhammad Muinul; Karim, Enayet; Sarker, Mst Naznin; Barman, Rashmisnata

doi:10.3329/fmcj.v6i2.9205

Cited by 10 publications

(15 citation statements)

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“…10 Another study done by Kabir et al showed that ulcerative lesion was 56%, ulceroproliferative lesion 10%, and polypoidal lesion 34%. 15 As per our study ulceroproliferative lesion was commonest (50%) followed by ulcerative lesion (26%).…”

Section: Discussionsupporting

confidence: 65%

“…In a study done by Kabir et al, abdominal pain (100%), vomiting (78%), dysphagia (24%), and weight loss (62%) were predominant symptoms pertaining gastric carcinoma. 9 Aird et al were the first to notice the correlation between gastric cancer and blood group A. The association between blood group A and gastric cancer has been mentioned in the studies of several groups.…”

Section: Discussionmentioning

confidence: 99%

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An epidemiological study of 50 consecutive cases of gastric cancer from a tertiary care hospital in West Bengal

et al. 2015

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Stomach cancer is the second-most common cancer among men and third-most among females in Asia and worldwide. 1 The symptoms and sign of stomach cancer are often reported late when the disease is already in advanced stages and 5-year survival is less than 30% in developed countries and around 20% in developing countries. 2 Despite of large number of such patients being treated in, there is lack of sufficient publications on the epidemiology of gastric cancer from India. 3 Most of the reported studies on gastric cancer from India are case reports or case series and few are case-control studies and they often deal with few specific risk factors associated with gastric cancer without looking into the entire spectrum of the disease. 4 Hence there is an urgent need for more research is to understand the etiology, develop suitable screening test, to demarcate high-risk population ABSTRACT Background: Gastric cancer in India shows marked regional variation both in incidence and presentation. Highest incidence is seen in the north eastern states of India. Its also common in West Bengal. However data on various clinicopathological characteristics of our gastric cancer patients is limited. The aim of this study was to find out the epidemiological profile of gastric cancer patients attending a tertiary care government hospital in West Bengal. Methods: 50 cases of gastric cancer patients were included in the study. They were admitted from surgical OPD. Patient characteristics were obtained using pretested questionnaire. All relevant investigations like endoscopy, biopsy reports, HPE and operative notes were recorded. Results: Average age of the patients was 51.76 years. There were 41 males and 9 females (4.56:1). There were 35 Hindus and 15 Muslims (2.33:1). 56% of the patients came from rural areas while the rest (44%) resided in urban areas. Weight loss was the commonest symptom followed by dyspepsia and abdominal pain. Majority of them were smokers (76%). Antrum was the commonest site of involvement and most common type of lesion was ulceroproliferative type (50%). Most of the gastric cancers were poorly differentiated adenocarcinomas. Indeterminate type was the commonest histological subtype. 16% of patients deemed operable on preoperative workup had advanced unresectable cancers. Conclusions: Majority of the gastric cancer patients appear to be male and Hindu by religion, mostly with a rural background. The average age at diagnosis was 51 years. Commonest symptoms were weight loss and dyspepsia. A high percentage of the patients were smokers with a long duration of smoking. About half of the patients had poorly differentiated cancers and indeterminate histology. A significant number of cases presented late with advanced disease. There is a need for urgent screening protocol to identify patients at earlier stages of the disease.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

An epidemiological study of 50 consecutive cases of gastric cancer from a tertiary care hospital in West Bengal

et al. 2015

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“…25 Another study by Kabir et al showed that ulcerative lesion was 56%, ulceroproliferative lesion 10% and polypoidal lesion 34%. 24 In this study, the most common type was ulceroproliferative (58%) followed by infiltrative (36%). The least common was ulcerative (6%) while the polypoidal type was not found.…”

Section: Macroscopical Typesmentioning

confidence: 56%

“…21,23 In a study done by Kabir et al, abdominal pain (100%), vomiting (78%), dysphagia (24%) and weight loss (62%) were predominant symptoms pertaining to gastric carcinoma. 24 Interview of 18,365 patients by the American college of surgeons, common presentations were weight loss (66.6%), abdominal pain (51.6%), nausea/vomiting (34%) and melaena (20.2%). Again Qurieshi et al showed common presenting symptoms as weight loss (35%), dyspepsia (76%), anorexia (35%) and vomiting (35.8%).…”

Section: Clinical Presentationmentioning

confidence: 99%

Clinicopathological Profile of Ca Stomach and Comparison of Preoperative Findings with Peroperative and Histopathological Findings

S¹,

Das²

2019

jemds

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A B S T R A C T BACKGROUNDGastric cancer has been one of the leading causes of cancer-related mortality over the past century. Today it is the 4 th most common cancer in the world. Surgery remains the only major curative option. Majority of these cancers are found to be unresectable on laparotomy. It is also frequently seen that patients with a preoperatively resectable cancer as per a staging CT-Scan of the abdomen are found to have unresectable disease on laparotomy. In this study, we are trying to assess the clinico-pathological profile of gastric cancer and tally the preoperative radiological findings with the peroperative and final histopathological findings. METHODSIt is a short-term prospective, observational study. 50 patients with gastric cancer permitted surgical intervention were prepared, operated, followed-up and preoperative, peroperative and final histopathological findings were tallied. RESULTS50 patients with gastric cancer were studied. The maximum age was 76 years and minimum age was 23 years with a mean age of 49.12 years with a standard deviation of 13.9776. Peak incidence was found in the age group of 41-60 years. 54% of the patients were male and 46% were female. The most common symptom was anorexia (94%, z-value 8.8) followed by weight loss (86%, z-value 7.2). The most common sign was anaemia which was present in 80% of the patients (z-value 6.0). 64% of the patients had intestinal type while 36% had diffuse type of gastric cancer. Patients with diffuse type were <50 years of age. Diffuse type was more common in females while intestinal type was more common in males. The accuracy of T, N, M staging on preoperative CT-Scan tallied with peroperative findings is 44%, 38% and 72% respectively. 44% of the patients underwent a palliative surgical procedure, of which 90.9% had poorly-differentiated and 9.1% had moderatelydifferentiated cancer. CONCLUSIONSPreoperative CT-Scan may not be a very accurate staging investigation for gastric cancer. It is poorly-differentiated cancers (both adenocarcinoma and signet-ring cell carcinoma) which have a greater possibility of being inaccurately staged by a preoperative CT-Scan.

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“…This is similar to results from other studies. 21,22 Some authors have reported that though the intestinal variant remains the commonest sub type, there is a relative increase in the incidence of the diffuse variant. 23,24 It has been suggested that this change may be as a result of a decreased rate of severe gastritis or due to changes in environmental carcinogenic factors in some populations.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and management of gastric cancer in Port Harcourt

Manuel

Danagogo

2020

Int Surg J

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Background: Gastric cancer is a relatively common cancer and has been documented as the 5th commonest cancer worldwide and the 3rd leading cause of cancer death. Surgery is the treatment of choice for operable cases while chemotherapy. It has a poor prognosis with a relative overall 5-year survival rate of 18%.Methods: This is a retrospective study of all patients that presented with gastric cancer to University of Port Harcourt Teaching Hospital between 1st January 2008 to 31st December 2017. Data were extracted and analyzed using the Statistical Package for Social Sciences (SPSS).Results: There were 14 males and 12 females seen within the study period making a male to female ratio of 1.2:1. Their ages ranged from 35 to 75 years with a mean of 54.7±4.8 years. The peak age incidence is in the 61-70-year age range. Four patients had curative surgery (D2 sub total gastrectomy) while 6 patients (23.1%) had D1 sub total gastrectomy. Post-operative complications occurred in 7 patients (26.9%). And the commonest was surgical site infection, seen in 4 patients (15.4%). Three patients died giving a mortality rate of 11.5%.Conclusions: Most patients with gastric cancer present with advance disease. The choice of treatment should be based on patient’s fitness, survival benefit and after an accurate assessment of extent of disease.

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Clinical Presentation, Histological Findings and Prevalence of <i>Helicobacter pylori</i> in Patients of Gastric Carcinoma

Cited by 10 publications

References 5 publications

An epidemiological study of 50 consecutive cases of gastric cancer from a tertiary care hospital in West Bengal

An epidemiological study of 50 consecutive cases of gastric cancer from a tertiary care hospital in West Bengal

Clinicopathological Profile of Ca Stomach and Comparison of Preoperative Findings with Peroperative and Histopathological Findings

Clinicopathological features and management of gastric cancer in Port Harcourt

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