Clinical presentation of <i>Helicobacter pylori</i>‐positive and ‐negative functional dyspepsia

Werdmuller, B. F. M.; Putten, Toon B.M.M. Van der; Balk, T. G.; Lamers, C. B. H. W.; Loffeld, R.J.L.F.

doi:10.1046/j.1440-1746.2000.02080.x

Cited by 26 publications

(18 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to organoleptic scoring, there was no clear relationship found between the gastric presence of H.pylori and halitosis. This result was in agreement with some other studies [47, 48, 59, 78]. However was not in agreement with the results of the studies conducted by Tiomny et al [49], Serin et al [50], Li et al [51], Katsinelos et al [79] and Chen et al [80].…”

Section: Discussionsupporting

confidence: 78%

The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints

et al. 2017

View full text Add to dashboard Cite

BackgroundThe oral cavity can be an extra-gastric reservoir for Helicobacter pylori (H.pylori). This can play a role in the pathogenesis of halitosis, glossitis, recurrent aphthous stomatitis, and dental caries. The present study was conducted to detect the presence of H.pylori within the dental biofilm and in saliva samples collected from children suffering from dyspepsia and children without any gastrointestinal complaints. Associations with gastric infection, halitosis, and some oral parameters were also evaluated.MethodsSeventy children (aged between 5–16) with dyspepsia were selected for the study group and control group composed of 30 healthy children without dyspepsia were also included in the study. After detailed oral and clinical examinations for oral parameters, saliva, and supragingival dental biofilm samples were collected for 16S rRNA and 23S rRNA genes detection by real-time polymerase chain reaction (RT-PCR). The presence of gastric H.pylori was evaluated in endoscopic biopsy specimens histopathologically. Halitosis was evaluated by benzoyl-DL-arginine-naphthylamid (BANA) test. Salivary S.mutans and Lactobacilli sp. counts were also carried out by commercial kits.Results H.pylori was histopathologically detected amongst 83% of the children with the dyspeptic condition. The detection rate of this bacteria in dental biofilm and saliva samples and halitosis were found relatively higher in the dyspeptic children rather than the control group (p < 0.01). Halitosis was not significantly different between dyspeptic children and those detected with H.pylori (p > 0.05). In the gastric H.pylori positive group with dyspepsia, DMFT/S and dmft/s numbers and plaque indices were found higher than the control group (p < 0.01). Only plaque indices of gastric H.pylori negative group with dyspepsia were found higher than the control group (p < 0.01). S.mutans and Lactobacilli sp. counts were not significantly different between gastric H.pylori positive and negative groups (p > 0.05). Comparing to those with negative for both genes, in children whose dental biofilm and saliva samples were positive for both 16S rRNA and 23S rRNA genes, significantly higher results for halitosis, and DMFS numbers and significantly lower results for dmfs numbers and pH values were found (p < 0.01).Conclusions Helicobacter pylori can occur in the oral cavity aside and independently from the stomach. However, the high number of bacteria in the oral cavities of children with gastric H.pylori, an association between the presence of H.pylori and halitosis, DMFS, and pH were found.Electronic supplementary materialThe online version of this article (doi:10.1186/s12903-017-0361-x) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionsupporting

confidence: 78%

The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints

et al. 2017

View full text Add to dashboard Cite

show abstract

“…19 Werdmuller et al have also shown that weight loss is significantly more common in the H. pylori infected patients. 20 On the other hand, Sarnelli et al demonstrated no difference in the clinical presentation of patients with or without H. pylori infection. 21 Recent reviews have highlighted the methodological problems in most of the therapeutic trials of anti-H. pylori treatment in patients with functional dyspepsia.…”

Section: Discussionmentioning

confidence: 98%

Role of helicobacter pylori in functional dyspepsia

Shrivastava¹,

Gupta²,

Gupta³

et al. 2006

Endoscopy

View full text Add to dashboard Cite

Background: The association of Helicobacter pylori with functional dyspepsia is widely reported, but it remains unclear whether H. pylori infection actually causes symptoms or is just an associated finding. Aims: This study was conducted to determine the role of H. pylori in causing symptoms of functional dyspepsia and to observe any improvement in symptoms after eradication of H. pylori. Setting and Design: This study was conducted in a prospective, randomised double-blind manner at the Surgery Department of our institution. Materials and Methods: Eighty patients with functional dyspepsia were randomly distributed into two groups to receive eradication or placebo therapy after taking biopsies for H. pylori. Symptom evaluation was done at baseline, at one and at three months to notice any improvement. Statistical Analysis: Changes in the dyspepsia score were compared using ANOVA test at baseline, one and at three months to compare the improvement in symptoms.Results: Approximately two-thirds of patients with functional dyspepsia are infected with H. pylori. Significant longterm improvement was observed after eradication in H. pylori infected patients. No significant improvement was seen with placebo therapy. Conclusion: H. pylori plays a significant role in causing symptoms of functional dyspepsia. Treatment with triple drug regimen brings a significant long-term improvement in the symptoms.

show abstract

“…There is no 100% clear correlation found between these ulcers and halitosis. 50,51 In vitro studies show significant VSC production by H. pylori . 52 More recent research by Lee et al 53 confirmed this statement.…”

Section: Originmentioning

confidence: 99%

Halitosis: the multidisciplinary approach

2012

View full text Add to dashboard Cite

Halitosis, bad breath or oral malodour are all synonyms for the same pathology. Halitosis has a large social and economic impact. For the majority of patients suffering from bad breath, it causes embarrassment and affects their social communication and life. Moreover, halitosis can be indicative of underlying diseases. Only a limited number of scientific publications were presented in this field until 1995. Ever since, a large amount of research is published, often with lack of evidence. In general, intraoral conditions, like insufficient dental hygiene, periodontitis or tongue coating are considered to be the most important cause (85%) for halitosis. Therefore, dentists and periodontologists are the first-line professionals to be confronted with this problem. They should be well aware of the origin, the detection and especially of the treatment of this pathology. In addition, ear–nose–throat-associated (10%) or gastrointestinal/endocrinological (5%) disorders may contribute to the problem. In the case of halitophobia, psychiatrical or psychological problems may be present. Bad breath needs a multidisciplinary team approach: dentists, periodontologists, specialists in family medicine, ear–nose–throat surgeons, internal medicine and psychiatry need to be updated in this field, which still is surrounded by a large taboo. Multidisciplinary bad breath clinics offer the best environment to examine and treat this pathology that affects around 25% of the whole population. This article describes the origin, detection and treatment of halitosis, regarded from the different etiological origins.

show abstract

Clinical presentation of Helicobacter pylori‐positive and ‐negative functional dyspepsia

Cited by 26 publications

References 15 publications

The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints

The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints

Role of helicobacter pylori in functional dyspepsia

Halitosis: the multidisciplinary approach

Contact Info

Product

Resources

About