Clinical presentation, pregnancy complications, and outcomes of pregnant women with <scp>COVID</scp>‐19 during the Omicron‐dominant third wave in Mumbai, India

Mahajan, Niraj N.; Kesarwani, Shweta; Salunke, Chetna; Kumbhar, Padmaja; Yenkure, Piyusha; Shaikh, Juvairiya; Shikhare, Shrutika; Mahale, Smita D.; Sachdeva, Geetanjali; Gajbhiye, Rahul

doi:10.1002/ijgo.14348

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…They reported higher maternal mortality among the symptomatic patients throughout their study period (overall death rate 17%, with 25% in the beta wave, 18% in the delta wave, and 5% in the omicron wave). This study supports our earlier observations of COVID‐19 disproportionately affecting pregnant and postpartum women in LMICs compared with high‐income countries (HICs) 3–6 …”

Section: Parameter First Wave Pre‐delta Period (April 2 2020 To Janua...supporting

confidence: 91%

“…This study supports our earlier observations of COVID-19 disproportionately affecting pregnant and postpartum women in LMICs compared with high-income countries (HICs). [3][4][5][6] Immediately after the declaration of COVID-19 pandemic, we launched the PregCovid registry (https://pregc ovid.com/) through the network of 19 government medical colleges in Maharashtra, India for capturing information of pregnant, postpartum women with COVID-19 and their newborns. The detailed information on study sites, inclusion and exclusion criteria of study participants, and data collection instruments was published elsewhere.…”

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confidence: 99%

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Different impact of COVID‐19 on symptomatic pregnant and postpartum women in low‐income countries and low‐ and middle‐income countries

Mahajan

Ansari

Munshi

et al. 2023

Intl J Gynecology & Obste

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Section: Parameter First Wave Pre‐delta Period (April 2 2020 To Janua...supporting

confidence: 91%

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confidence: 99%

Different impact of COVID‐19 on symptomatic pregnant and postpartum women in low‐income countries and low‐ and middle‐income countries

Mahajan

Ansari

Munshi

et al. 2023

Intl J Gynecology & Obste

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“…Of the 18 studies included [ 9 , 10 , 12 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], most were limited to America ( n = 6), followed by Turkey and the UK (3 in Turkey, 2 in Turkey and the UK, 1 in the UK). The included studies described maternal and perinatal outcomes of different SARS-CoV-2 variant infections during pregnancy, involving a total of 133,058 cases of SARS-CoV-2 infection during pregnancy, and 99,567 cases of SARS-CoV-2 wild type or pre-variant infections (4129 wild type infections, 93,825 pre-Delta infections, 1416 pre-variant infections, 130 pre-Omicron infections, 67 pre-Alpha infections) and 33,494 cases of SARS-CoV-2 variant infections (2587 Alpha infections, 29,016 Delta infections, 1843 Omicron infections, 25 Alpha or Gamma infections, 23 Alpha or Beta infections).…”

Section: Resultsmentioning

confidence: 99%

Association of Infection with Different SARS-CoV-2 Variants during Pregnancy with Maternal and Perinatal Outcomes: A Systematic Review and Meta-Analysis

Deng

Liu

et al. 2022

IJERPH

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The aim of this study is to review the currently available data, and to explore the association of infection with different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants during pregnancy with maternal and perinatal outcomes in the real world. Observational cohort studies were analyzed that described the maternal and perinatal outcomes of infection with different SARS-CoV-2 variants during pregnancy. Random-effects inverse-variance models were used to evaluate the pooled prevalence (PP) and its 95% confidence interval (CI) for maternal and perinatal outcomes. Random effects were used to estimate the pooled odds ratios (OR) and their 95% CI for different outcomes between Delta and pre-Delta periods, and between Omicron and Delta periods. Eighteen studies, involving a total of 133,058 cases of SARS-CoV-2 infection during pregnancy (99,567 cases of SARS-CoV-2 wild type or pre-variant infection and 33,494 cases of SARS-CoV-2 variant infections), were included in this meta-analysis. Among pregnant women with SARS-CoV-2 infections, the PPs for required respiratory support, severe or critical illness, intensive care unit (ICU) admission, maternal death, and preterm birth <37 weeks were, respectively, 27.24% (95%CI, 20.51–33.97%), 24.96% (95%CI, 15.96–33.96%), 11.31% (95%CI, 4.00–18.61%), 4.20% (95%CI, 1.43–6.97%), and 33.85% (95%CI, 21.54–46.17%) in the Delta period, which were higher than those in the pre-Delta period, while the corresponding PPs were, respectively, 10.74% (95%CI, 6.05–15.46%), 11.99% (95%CI, 6.23–17.74%), 4.17% (95%CI, 1.53–6.80%), 0.63% (95%CI, 0.05–1.20%), and 18.58% (95%CI, 9.52–27.65%). The PPs for required respiratory support, severe or critical illness, and ICU admission were, respectively, 2.63% (95%CI, 0.98–4.28%), 1.11% (95%CI, 0.29–1.94%), and 1.83% (95%CI, 0.85–2.81%) in the Omicron period, which were lower than those in the pre-Delta and Delta periods. These results suggest that Omicron infections are associated with less severe maternal and neonatal adverse outcomes, though maternal ICU admission, the need for respiratory support, and preterm birth did also occur with Omicron infections. Since Omicron is currently the predominant strain globally, and has the highest rates of transmission, it is still important to remain vigilant in protecting the vulnerable populations of mothers and infants. In particular, obstetricians and gynecologists should not ignore the adverse risks of maternal ICU admission, respiratory support, and preterm births in pregnant patients with SARS-CoV-2 infections, in order to protect the health of mothers and infants.

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“…59 We reviewed 25 studies reporting specific information relating to SARS-CoV-2 variants, including 3667 pregnancies with the wild-type strain, 1740 pregnancies with the Alpha variant, 35,673 pregnancies with the Delta variant, and 11,968 pregnancies with the Omicron variant. [17][18][19][20]51,52,54,57,[59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75] Table 1 shows the clinical characteristics and maternal outcomes of pregnancies with SARS-CoV-2 infection. Maternal deaths arising from COVID-19 infection were rare, irrespective of whether the cases involved the wild-type strain or variants.…”

Section: Maternal Outcomesmentioning

confidence: 99%

“…We reviewed 25 studies reporting specific information relating to SARS-CoV-2 variants, including 3667 pregnancies with the wild-type strain, 1740 pregnancies with the Alpha variant, 35,673 pregnancies with the Delta variant, and 11,968 pregnancies with the Omicron variant 17–20,51,52,54,57,59–75 Table 1. shows the clinical characteristics and maternal outcomes of pregnancies with SARS-CoV-2 infection.…”

Section: Maternal Outcomesmentioning

confidence: 99%

Maternal and Perinatal Outcomes of SARS-CoV-2 and Variants in Pregnancy

et al. 2023

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Pregnancy is a physiological state that predisposes women to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a disease that can cause adverse maternal and perinatal outcomes. The severity of coronavirus disease 2019 (COVID-19) disease is known to vary by viral strain; however, evidence for the effects of this virus in pregnant women has yet to be fully elucidated. In this review, we describe maternal and perinatal outcomes, vaccination, and vertical transmission, among pregnant women infected with the different SARS-CoV-2 variants identified to date. We also summarize existing evidence for maternal and perinatal outcomes in pregnant women with specific information relating to SARS-CoV-2 variants. Our analysis showed that Omicron infection was associated with fewer severe maternal and perinatal adverse outcomes while the Delta variant was associated with worse pregnancy outcomes. Maternal deaths arising from COVID-19 were found to be rare (<1.0%), irrespective of whether the virus was a wild-type strain or a variant. Severe maternal morbidity was more frequent for the Delta variant (10.3%), followed by the Alpha (4.7%), wild-type (4.5%), and Omicron (2.9%) variants. The rates of stillbirth were 0.8%, 4.1%, 3.1%, and 2.3%, respectively, in pregnancies infected with the wild-type strain, Alpha, Delta, and Omicron variants, respectively. Preterm birth and admission to neonatal intensive care units were more common for cases with the Delta infection (19.0% and 18.62%, respectively), while risks were similar for those infected with the wild-type (14.7% and 11.2%, respectively), Alpha (14.9% and 13.1%), and Omicron variants (13.2% and 13.8%, respectively). As COVID-19 remains a global pandemic, and new SARS-CoV-2 variants continue to emerge, research relating to the specific impact of new variants on pregnant women needs to be expanded.

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Clinical presentation, pregnancy complications, and outcomes of pregnant women with COVID‐19 during the Omicron‐dominant third wave in Mumbai, India

Cited by 9 publications

References 12 publications

Different impact of COVID‐19 on symptomatic pregnant and postpartum women in low‐income countries and low‐ and middle‐income countries

Different impact of COVID‐19 on symptomatic pregnant and postpartum women in low‐income countries and low‐ and middle‐income countries

Association of Infection with Different SARS-CoV-2 Variants during Pregnancy with Maternal and Perinatal Outcomes: A Systematic Review and Meta-Analysis

Maternal and Perinatal Outcomes of SARS-CoV-2 and Variants in Pregnancy

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