Clinical Presentations and Predisposing Factors of Cholelithiasis and Sludge in Children

Wesdorp, I. C. E.; Bosman, D. K.; Graaff, Aafke de; Aronson, Daniël C.; Blij, Frits Van Der; Taminiau, J. A. J. M.

doi:10.1097/00005176-200010000-00015

Cited by 172 publications

(224 citation statements)

References 22 publications

Supporting

Mentioning

170

Contrasting

Unclassified

Order By: Relevance

“…Unlike adults having an asymptomatic disease over 80% (14,15), children are less likely to present with asymptomatic presentation, ranging between 17%-50% (6,12,16). In the present study, the frequency of asymptomatic disease was concordant with the current literature by comprising 38.7% of the entire study population.…”

Section: Discussionsupporting

confidence: 89%

“…(1)(2)(3)(4)(5). Although the exact prevalence of gallstones in children is not known, studies have shown an overall prevalence of 0.13% to 1.9% in children (1,6,7).…”

Section: Introductionmentioning

confidence: 99%

“…For asymptomatic adults, expectant management with periodical clinical and sonographic controls is recommended (8). In children, the data on the natural history of asymptomatic gallstones are limited, and small series suggest conservative management for those without symptoms (6,9). Ursodeoxycholic acid (UDCA) as a nonsurgical approach has been rarely studied in children and found to be ineffective (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A retrospective review of children with gallstone: Single-center experience from Central Anatolia

Gökçe

Yıldırım²,

Erdoğan³

2014

Turk J Gastroenterol

View full text Add to dashboard Cite

Background/Aims: To evaluate children with gallstone in respect to demographic features, type of presentation, predisposing risk factors, laboratory features, complications, and outcome. Materials and Methods: Overall, 124 children with sonographically diagnosed gallstone were stratified into group 1 (symptomatic) and group 2 (asymptomatic). The data on demographic features, predisposing risk factors, laboratory features, complications, and outcome were collected from medical charts and compared by using convenient statistical methods.Results: There were 76 (61%) children in group 1. Females were significantly older than males at the time of diagnosis (p=0.001). After adjusting for age and sex, asymptomatic presentation was associated with hemolytic anemia (r=346, <0.001) and being an oncologic patient (r=248, p=0.006). No risk factor was specifically associated with having a symptomatic presentation. Sixteen children (12.9%) developed complications: 14 (18.4%) in group 1 and 2 (4.2%) in group 2 (p=0.027). Gallstone resolution was detected in 20 (29.4%) and 10 children (23.3%) in groups 1 and 2, respectively (p=0.477). Resolution was observed in 43.8% of children with ceftriaxone-associated gallstone. The rate of resolution with ursodeoxycholic acid (UDCA) was similar to that observed with expectant management. Gallstone resolution was evident in 9 infants (50.0%) and was significantly higher than children over 2 years of age (21 out of 106 children, 19.8%) (p=0.006). The most important factor associated with gallstone resolution was to be an infant (<2 years of age) at the time of diagnosis (OR: 3.1; 95% CI: 1.1-8.8; p=0.034). Conclusion: Ceftriaxone-associated gallstones are most likely to resolve but do not always undergo spontaneous resolution. UDCA treatment seems to be ineffective. Young age is a favorable factor for gallstone resolution. The rate of complications in children with asymptomatic presentation is considerably low. Thus, clinical follow-up rather than surgical intervention is suggested in children with asymptomatic presentation and in infants.

show abstract

Section: Discussionsupporting

confidence: 89%

“…(1)(2)(3)(4)(5). Although the exact prevalence of gallstones in children is not known, studies have shown an overall prevalence of 0.13% to 1.9% in children (1,6,7).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A retrospective review of children with gallstone: Single-center experience from Central Anatolia

Gökçe

Yıldırım²,

Erdoğan³

2014

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Gallstones are increasingly found in childhood, not only because of the use of ultrasonography in the workup of abdominal pain but also because of the increase of incidence in obesity worldwide and the high frequency of hemolytic anemias in all countries [1][2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…In the past, gallbladder disease in children was usually observed primarily in patients with comorbid conditions such as hemolytic disorders, parenteral nutrition dependence, or cystic fibrosis [2,3]. However, the cholecystectomy rate in children without the diagnosis of hemolytic anemia has doubled in United States in recent years [4].…”

mentioning

confidence: 99%

Management of gallstone disease in children: a new protocol based on the experience of a single center

Tannuri

Leal

Velhote

et al. 2012

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Effect of Orlistat on Weight and Body Composition in Obese Adolescents

Chanoine¹,

Hampl²,

Jensen³

et al. 2005

JAMA

529

287

View full text Add to dashboard Cite

HE PREVALENCE OF OVERweight in adolescents is increasing worldwide. In the United States, the proportion of adolescents with a body mass index (BMI) at or above the 95th percentile for age, a widely accepted definition of obesity in adolescents, 1,2 has increased 15.5% to 23.4% in certain ethnic minorities. 3 A similar picture is seen in European countries: the prevalence of overweight in adolescents has increased 8% to 21% in northern European countries and 17% to 23% in southern European countries. 4 Excess weight in adolescents is associated with an increased risk of disorders such as hyperlipidemia and type 2 diabetes 5 and can result in decreased emotional and physical quality of life. 6,7 In addition, childhood obesity results in increased risk of morbidity and mortality in adulthood. 8,9 Long-term follow-up studies of children and adolescents indicate that overweight children have a 15-fold greater risk of becoming overweight adults compared with those children and adolescents who were not overweight. 8 Effective weight management in children and adolescents may therefore have important immediate and future societal health benefits. Treatment of obesity in the pediatric age group, and in particular during adolescence, 10 is notoriously difficult. While behavioral therapy has had some success in treating obesity in young children (aged 6-12 years), most stud-For editorial comment see p 2932.

show abstract

Clinical Presentations and Predisposing Factors of Cholelithiasis and Sludge in Children

Cited by 172 publications

References 22 publications

A retrospective review of children with gallstone: Single-center experience from Central Anatolia

A retrospective review of children with gallstone: Single-center experience from Central Anatolia

Management of gallstone disease in children: a new protocol based on the experience of a single center

Effect of Orlistat on Weight and Body Composition in Obese Adolescents

Contact Info

Product

Resources

About