Clinical presentations of rotavirus infection among hospitalized children

Abstract

RV detection was greatest when diarrhea, vomiting and fever occurred together and lowest when each symptom occurred alone. The spectrum of symptoms of rotavirus disease in children at the time of admission to the hospital or short stay unit may be broader than previously recognized.

Prevalence and Molecular Genotyping of Group A Rotaviruses in Iranian Children

“…Most cases occur in children less than 5 years of age. The prevalence of rotavirus in children with diarrhoea varies from 30 to 50 % [14]. From 2009 to 2010, consecutive surveillance of rotavirus diarrhoea in children under 5 years of age in Jahrom, Iran showed a prevalence of 46 %, which is similar to other reports [1,15].…”

RIX4414 (Rotarix™): uma vacina contra o rotavírus humano com vírus vivo atenuado

“…The symptoms associated with rotavirus disease typically are diarrhea and vomiting accompanied by fever, nausea, anorexia, cramping, and malaise that can be mild and of short duration or produce severe dehydration. 5,6 Severe disease occurs primarily in young children, most commonly among those aged 6 to 24…”

“…Antibodies to these two proteins, and only these two proteins, are capable of neutralizing the virus in vitro. There are at least 14 types of the VP7, with five of them being common in human disease (G1-4 and G9), in There are at least 25 VP4 types, three of which are seen in humans (P [8], P [4], and P [6]). The most common combinations of VP7 and VP4 are G1P [8], G3P [8], G4P [8], G9P [8] G9P [6], and G2P [4].…”

“…There are at least 14 types of the VP7, with five of them being common in human disease (G1-4 and G9), in There are at least 25 VP4 types, three of which are seen in humans (P [8], P [4], and P [6]). The most common combinations of VP7 and VP4 are G1P [8], G3P [8], G4P [8], G9P [8] G9P [6], and G2P [4]. True heterologous protection would be against a virus that differs in both of these proteins.…”

“…True heterologous protection would be against a virus that differs in both of these proteins. Protection by the G1P [8] strain found in Rotarix™ against a G2P [6] infection would be an example of the heterologous protection, while protection of G1P [8] against G3P [8], G4P [8] and G9 P [8] would not be considered truly heterologous because they share the VP4 protein. Thus, the protection against G9…”