Clinical Profile and Treatment Evaluation of Rifampicin-Resistant and Multidrug-Resistant Tuberculosis Patients at Dr. Kanujoso Djatiwibowo Public Hospital, Balikpapan

Adiwinata, Randy; Rasidi, Josephine; Marpaung, Maurits

doi:10.36497/jri.v38i3.2

Cited by 5 publications

(10 citation statements)

References 7 publications

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“…Based on Table 1, from 178 DR TB patients, 34.2% RR TB patients and 65.8% MDR TB patients were found. This result differed from studies by Tirtana & Musrichan (2011) and Adiwinata et al (2018), which stated that monoresistance to rifampicin was the most common resistance pattern. It might be because isoniazid and rifampicin are the first-line active drugs in TB therapy.…”

Section: Characteristics Of Drug-resistant Tb Patientscontrasting

confidence: 99%

Diabetes Mellitus and History of Tuberculosis Treatment as Risk Factors of Developing Multidrug-Resistant Tuberculosis at TB Polyclinic Dr. Soetomo General Hospital 2019 - 2020

Habibi

Bakhtiar²,

Indiastuti³

et al. 2022

JIUBJ

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Multidrug-Resistant Tuberculosis (MDR TB) is a condition when Mycobacterium tuberculosis were resistant to Isoniazid and Rifampicin simultaneously, with or without being followed by other first-line Anti-Tuberculosis Drugs. Diabetic patients who also have TB are more susceptible to drug resistance. There is ample evidence noting that a history of previous TB treatment is one of the main factors contributing to the development of MDR TB. This study was a case-control study. The sample of this study was all patients from TB Polyclinic Dr. Soetomo Hospital who were diagnosed with pulmonary TB by pulmonologists on January 1, 2019 – December 31, 2020, who met the inclusion criteria. The data obtained were analyzed using the IBM SPSS Statistics 23 application with a binary logistic regression test.There were 178 samples of this study. MDR TB (65.8%) was the dominant resistance type in Drug-Resistant Tuberculosis (DR TB) patients. Patients with DM were 2.2 times more likely to develop MDR TB than patients without DM. Patients with histories of previous tuberculosis (TB) treatment tended to be three times more likely to develop MDR TB than new patients. Other factors such as age, sex, BMI, history of alcohol consumption, and history of smoking did not show a significant relationship with the incidence of MDR TB. Diabetes Mellitus comorbidity and history of previous Tuberculosis treatment were significant risk factors for developing MDR TB.

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Section: Characteristics Of Drug-resistant Tb Patientscontrasting

confidence: 99%

Diabetes Mellitus and History of Tuberculosis Treatment as Risk Factors of Developing Multidrug-Resistant Tuberculosis at TB Polyclinic Dr. Soetomo General Hospital 2019 - 2020

Habibi

Bakhtiar²,

Indiastuti³

et al. 2022

JIUBJ

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“…Moreover, other intervention such as counselling, health education, as well as adequate support was mandatory in patients with MDR-TB. It is expected to improve the management and to limit the drop out case (Adiwinata, Rasidi, Marpaung, Timur, & Timur, 2018). An effective early diagnosis and pharmacotherapy would be key to reduce failure of TB treatment (Bhatt, Chopra, & Vashisht, 2019).…”

Section: Methodsmentioning

confidence: 99%

Knowledge, Behavior, and Role of Health Cadres in The Early Detection of New Tuberculosis Case in Wonogiri

Ratnasari¹,

Marni²,

Husna³

2019

Kemas

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Tuberculosis (TB) is an infectious disease that remain a serious health problem. Seventy five percent of TB cases in developing countries are found in people of productive age. Delay in case finding and handling will lead to disability and death and hamper TB control program. The objective of this study was to evaluate how far the role of health cadres in detecting new case of TB in Tirtomoyo, Wonogiri. The study design was a cross-sectional and data was collected from February to April 2019. The population of the study was all health cadres in Tirtomoyo numbering 465 cadres from 9 villages. Sample of the study was the cadres in Tirtomoyo who met inclusion criteria set by the researchers with total number of 202 cadres. The sampling technique was purposive sampling, and the inclusion criteria included: active person, in a healthy state, not currently receiving inpatient care in hospital, and agree to participate in the study. Subjects completed the questionnaire consisting of sociodemographic data, knowledge, behavior, and the role of cadre. The data was analyzed using SPSS version 22. The behavior of the health cadres was found to significantly correlate to the role of cadres in early detection of new TB cases with p value of 0.039 (OR 0.121– 0.946). The health cadres play an essential role, and active screening for TB detection was more effective than passive screening. Early diagnosis would affect the success of the TB treatment program.

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“…9 History of previous TB treatment such as failed category 1 TB cases, relapsed TB cases, and dropped out of treatment are groups at high risk of developing resistance. 10 Comorbidity can also be a risk factor for anti-TB drug resistance associated with decreased immunity. 11 Based on the differences in first-line anti-TB drug resistance patterns in various places and the previously mentioned facts, there are several opportunities in the development of studies on first-line anti-TB drug resistance patterns in Indonesia.…”

Section: Original Articlementioning

confidence: 99%

“…19 Another study in Balikpapan, Indonesia also showed that the dominant pattern was HR in 5 of 15 patients (33.3%) and followed by isoniazid, rifampicin, pyrazinamide, ethambutol (HRZE) in 2 patients (13.3%). 10 Based on several studies in Indonesia, the dominant pattern of first-line anti-TB drug resistance in Indonesia is HR. 10,18,19 This may be due to the fact that isoniazid and rifampicin are the first-line active drugs in TB therapy.…”

Section: First-line Anti-tuberculosis Drug Resistance Patternmentioning

confidence: 99%

“…10 Based on several studies in Indonesia, the dominant pattern of first-line anti-TB drug resistance in Indonesia is HR. 10,18,19 This may be due to the fact that isoniazid and rifampicin are the first-line active drugs in TB therapy. Therefore, the possibility of isoniazid and rifampicin used as monotherapy or in combination with other antibiotics is higher.…”

Section: First-line Anti-tuberculosis Drug Resistance Patternmentioning

confidence: 99%

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First-Line Anti-Tuberculosis Drug Resistance Pattern

Heriqbaldi

Setiabudi

Meliana

2022

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Introduction: Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis and usually attacks the lungs. Indonesia is in the third rank of TB cases in the world. An important concern regarding TB currently is the case of anti-TB drug resistance, hence research on resistance patterns and risk factors is essential. This study aimed to identify the pattern of first-line anti-TB drug resistance at Dr. Soetomo General Hospital, Surabaya.Methods: A descriptive retrospective study was conducted at Dr. Soetomo General Hospital, Surabaya for the period of 2017-2019. The samples were obtained through total population sampling of 239 pulmonary TB patients with first-line anti-TB drug resistance which were registered at MDR-TB Polyclinic Dr. Soetomo General Hospital, Surabaya. Only complete medical records were included. The variables were first-line anti-TB drug resistance (isoniazid, rifampicin, ethambutol, streptomycin) and patients’ characteristics (age, gender, treatment history, and comorbidities). The drug resistance test was performed using certified culture methods.Results: Among 239 patients, the incidences of resistance to H, R, E, and S were 79.08%, 94.14%, 25.94%, and 20.08%, respectively. The most common patterns were HR (42.26%), R (18.83%), and HRE (12.55%). The largest age group was 45-54 years old (38%). The dominant gender was male (56.49%). The most treatment history category was relapsed patients (48%) and there were more patients with comorbidity (57%).Conclusion: The highest incidence rate of resistance was rifampicin and the most common resistance pattern was HR. Most of the patients were of working age, male, relapse patients, and had comorbidities. An appropriate TB therapy treatment plays an important role in preventing resistance.

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Clinical Profile and Treatment Evaluation of Rifampicin-Resistant and Multidrug-Resistant Tuberculosis Patients at Dr. Kanujoso Djatiwibowo Public Hospital, Balikpapan

Cited by 5 publications

References 7 publications

Diabetes Mellitus and History of Tuberculosis Treatment as Risk Factors of Developing Multidrug-Resistant Tuberculosis at TB Polyclinic Dr. Soetomo General Hospital 2019 - 2020

Diabetes Mellitus and History of Tuberculosis Treatment as Risk Factors of Developing Multidrug-Resistant Tuberculosis at TB Polyclinic Dr. Soetomo General Hospital 2019 - 2020

Knowledge, Behavior, and Role of Health Cadres in The Early Detection of New Tuberculosis Case in Wonogiri

First-Line Anti-Tuberculosis Drug Resistance Pattern

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