Clinical profile of congenital diaphragmatic hernia and their short-term outcome in a tertiary care neonatal unit: A retrospective study

Abstract

ongenital diaphragmatic hernia (CDH) remains one of the most difficult problems of the perinatology and neonatal surgery. Western literature showing 90% of survival rate is not reflected in our population. Initial stabilization of the neonate with advanced ventilatory techniques and optimal management of associated pulmonary hypertension by the neonatologist has significantly lowered the operative mortality in developed countries. However, the mortality rate in developing countries is still 40-50% [1]. Several predictors of mortality have been suggested, including polyhydramnios, early prenatal diagnosis, intrathoracic stomach, intrathoracic liver, presence of associated anomalies, right-sided hernia, and low Apgar scores [2].Hence, this study was carried out to analyze the clinical profile of neonates with CDH and determines the risk factors associated with mortality in these neonates. RESULTSCase records of 148 patients with a diagnosis CDH were reviewed. The mean age at admission, birth weight, sex, and

Analysis of prognostic factors in congenital diaphragmatic hernia in neonates

“…Studies from other Indian centers have reported survival rate ranging from 58% to 78%. [234] On the other hand, studies from developed countries have reported a survival rate of 85%–90% with protocolized care. [67]…”

Outcomes of neonatal congenital diaphragmatic hernia in a non-ECMO center in a middle-income country: a retrospective cohort study

“…Over the past two decades, studies from South and Southeast (SE) Asian countries, mostly involving relatively small numbers of neonates and with varying selection criteria, report survival rates ranging from 56-78% in India [14][15][16][17][18], 52% in Malaysia [19], and 56-79% in Taiwan [20,21] and Singapore [8,22], moving from low-middle, upper-middle, and high-income countries, respectively. Antenatal diagnosis varies between 5-79% in these studies and risk factors for non-survival include an antenatal diagnosis, low Apgar score, the presence of moderate-to-severe persistent pulmonary hypertension of the newborn (PPHN), pneumothorax, and high oxygenation index (OI).…”