Clinical profile of cutaneous adverse effects induced by topical corticosteroids and their source of information

Zaidi, Aliza; Saxena, Kshitij; Koti, Ven R.; Singh, Anukriti; Khalid, Ayesha N.; Jamil, Reyan Abdul

doi:10.18203/issn.2455-4529.intjresdermatol20212547

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Бесконтрольное применение ГКС может приводить к целому ряду побочных эффектов, включаю щих как патологические изменения кожи, так и выраженные негативные системные реакции. Среди нежелательных кожных реакций наиболее часто встречаются атрофия, телеангиоэктазии, фолликулит, обострение существующей инфекции, спровоцированные стероидами розацеа и акне, нарушение пигментации, фотосенсибилизация [6]. Несмотря на то что при наружном применении доза ГКС в разы меньше, чем при системной терапии, их длительное применение, особенно на большой площади кожных покровов, может приводить к формированию экзогенного синдрома Иценко -Кушинга [7].…”

Section: Introductionunclassified

Topical glucocorticosteroids: from high clinical efficacy to the problem of uncontrolled use (case report)

et al. 2023

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Due to their pronounced biological activity, glucocorticosteroids are widely used in various fields of medical practice. The variety of effects of these hormones makes them an important part of the treatment of dermatological patients. This group of drugs has a pronounced positive effect on various links in the pathogenesis of many chronic dermatoses due to anti-inflammatory, vasoconstrictive, immunosuppressive and antiproliferative effects. The creation of combined external preparations containing a glucocorticosteroid in combination with an antibacterial and/or antifungal component has become a significant achievement in dermatological practice. Due to the rapid relief of signs of inflammation, as well as additional antibacterial and antifungal effects, these external agents have become especially attractive to patients. Widespread advertising and over-the-counter sale of drugs containing glucocorticosteroids leads to the fact that a significant part of patients seek advice from a dermatologist only after their ineffective use. At the same time, their uncontrolled use can lead to a number of side effects, including both pathological changes in the skin and pronounced negative systemic reactions. This fact significantly changes the clinical picture of the disease, limits the possibilities of early laboratory diagnosis of infection, which often prolongs the time for verification of the diagnosis and complicates therapy. The article presents our own clinical observations of patients with skin mycoses who have been using combined topical preparations containing glucocorticosteroids for a long time. This led to an atypical clinical course of the infection and required additional diagnostics using histological examination. The analysis of clinical observations is intended to focus the attention of primary care physicians on this problem, which can increase patient awareness of the risks of using topical drugs containing glucocorticosteroids.

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Section: Introductionunclassified

Topical glucocorticosteroids: from high clinical efficacy to the problem of uncontrolled use (case report)

et al. 2023

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Optimized and safe use of topical corticosteroids in pediatric dermatology through interdisciplinary collaboration: a review

Sreeraj,

Risana,

Mathew

et al. 2024

Discov Med

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The use of topical corticosteroids (TCs) in pediatric patients is a common therapeutic approach for various dermatological conditions. However, their application can lead to a spectrum of adverse drug reactions (ADRs), from localized skin changes to systemic effects. Due to factors such as thinner skin, enhanced cutaneous absorption, and developing organ systems, pediatric populations are particularly vulnerable to TCs-led ADRs. The most common ADRs associated with the use of TCs in the pediatric population include skin atrophy, striae, and telangiectasia. Other less common ADRs include allergic contact dermatitis, perioral dermatitis, and systemic effects such as suppression of the hypothalamic–pituitary–adrenal (HPA) axis, etc. To minimize the possibility of ADRs and unwanted medication reactions, rational and safe use of TCs shall be promoted. Clinical Pharmacists (CPs) play a pivotal role in ensuring appropriate and safe utilization of TCs in pediatric patient care. CPs collaborate with healthcare practitioners to design individualized treatment regimens considering factors such as age, skin type, and medical history. They also educate patients and caregivers on proper TCs application techniques, therapy duration, and potential side effects, thereby facilitating better adherence and treatment outcomes. Clinical research specific to pediatric populations is essential to provide precise insights into TCs effectiveness and safety, accounting for age-related variations and long-term consequences. TCs represent a valuable tool in pediatric dermatology, but their use requires careful consideration of the risks and benefits, active involvement of CPs, regulatory measures, and ongoing research to optimize therapy outcomes and safety in pediatric patients.

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Evaluation of the effectiveness of a moisturizing cream as an adjuvant in the treatment of eczema: A preliminary real-world study report

Gala

Muchhala

Rathod

et al. 2022

CSDM

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Objectives: Eczema is a papulosquamous disease characterized by itchy, dry, rough, flaky, inflamed, and irritated skin on arms, inner elbows, backs of the knees, or head. Numerous skin conditions can be managed with the help of moisturizers. Venusia® Max is a moisturizing cream meant for eczema with a unique combination of four butters – shea, cocoa, mango, and aloe that act as emollients along with glycerin, propylene glycol, emulsifying wax, and cyclomethicone. The study’s objective is to assess Venusia® Max cream’s moisturizing efficacy when used as an adjuvant to the main line of treatment for eczema. Material and Methods: This monocentric, real-world setting study evaluates the effectiveness of Venusia® Max as an adjuvant, along with prescribed treatment in patients with eczema, versus prescribed treatment only (without Venusia® Max) as well as baseline. One hundred and twenty subjects enrolled in the study were divided in two groups: 1. Receiving Venusia® Max cream as an adjuvant, along with prescribed treatment and 2. receiving prescribed treatment only. The subjects were assessed for eczema area and severity index (EASI) scores, skin hydration using moisture meter-SC, transepidermal water loss (TEWL) using VapoMeter, and subject self-assessment of itching, cutaneous dryness, and burning sensation. Results: In the group with Venusia® Max cream, significant reduction in the EASI score, burning sensation, itching, and TEWL along with significant increase in skin hydration was observed when compared to baseline. Conclusion: Thus, Venusia® Max cream offers a novel and effective topical treatment for the dry skin of eczema patients.

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Clinical profile of cutaneous adverse effects induced by topical corticosteroids and their source of information

Cited by 3 publications

References 16 publications

Topical glucocorticosteroids: from high clinical efficacy to the problem of uncontrolled use (case report)

Topical glucocorticosteroids: from high clinical efficacy to the problem of uncontrolled use (case report)

Optimized and safe use of topical corticosteroids in pediatric dermatology through interdisciplinary collaboration: a review

Evaluation of the effectiveness of a moisturizing cream as an adjuvant in the treatment of eczema: A preliminary real-world study report

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