Clinical profile of dengue and predictive severity variables among children at a secondary care hospital of Chilpancingo, Guerrero, Mexico: case series

Alvarado-Castro, Víctor Manuel; Ramírez-Hernández, Elizabeth; Paredes-Solís, Sergio; Legorreta-Soberanis, José; Saldaña-Herrera, Vianey Guadalupe; Salas-Franco, Liliana Sarahí; Castillo-Medina, Jorge Alberto del; Andersson, Neil

doi:10.1016/j.bmhime.2016.06.003

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…Our exploration revealed that the 2019 outbreak was characterized by fever in all patients with the most common associated features being nausea and/or vomiting, severe headache, anorexia, and retro-orbital pain. These are the general features of dengue fever [25] and are well correlated with other similar studies [29][30][31]. But this year hemorrhagic presentation was relatively less common with approximately 5% having one or more bleeding manifestations.…”

Section: Discussionsupporting

confidence: 82%

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Hasan¹,

Tabassum²,

Sharif

et al. 2021

BMC Infect Dis

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Background The clinical presentation of dengue fever had been observed to change with time since its first outbreak in 2000 in Bangladesh. This report showed the clinical presentation of the 2019 outbreak in Bangladesh along with its comparison to previous outbreaks witnessed in this region. Methods This hospital-based cross-sectional study was conducted in one of the largest tertiary care hospitals in Dhaka city. A total of 553 laboratory-confirmed and 194 probable dengue cases were interviewed. The clinical manifestation of the confirmed cases of the current outbreak was compared with three of the outbreak reports retrieved from the databases. R version 3.6.3 was used for data analysis. Results Among the confirmed cases, two-thirds were male (63.2%) and the average age was 27(± 11) years. Positive tests for NS1 and IgM were present in 99.6% (n = 525/527) and 82.6% (n = 38/46) of the cases, respectively. Thrombocytopenia was present in 66.1% of cases. Fever (100%) was common for all. Gastrointestinal (GIT) features, including abdominal pain (86.5%), anorexia and/or vomiting (69.6%), and Diarrhea (> 3 motions/day) (26.2%) were more frequent than typical rash and other pain symptoms. Hypotension was present in approximately a quarter of patients (25%). GIT features (anorexia, nausea, and/or vomiting) and hypotension were more common among adult participants while bleeding manifestation (melena and vaginal bleeding, p = 0.009 & 0.032) was more frequent in pediatric patients. Compared to outbreaks of 2008, 2016, and 2018, increasing trends in GIT symptoms e.g. anorexia, abdominal pain, and diarrhea were observed. While a negative trend in hemorrhagic manifestations (skin rash, melena, and conjunctival hemorrhage/hemorrhagic sclera) and arthralgia/joint pain were found. Conclusion The present outbreak was noticeably characterized by GIT symptoms and hypotension in addition to the typical clinical features like rash and pain symptoms. An increasing trend in GIT features and decreasing trend in hemorrhagic manifestations was noted over the last decade of dengue outbreaks.

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Section: Discussionsupporting

confidence: 82%

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Hasan¹,

Tabassum²,

Sharif

et al. 2021

BMC Infect Dis

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“…21 out of 30 severe dengue cases (70%) presented with fever spike of temperature above 39• C. There was statistically significant association between fever spike with temperature above 39•C and severe dengue as also reported by Alvarado-castro et al [11] .…”

Section: Resultssupporting

confidence: 76%

Clinical and Laboratory Profile of Children with Dengue Fever and Predictors of Severe Dengue

Sahana¹,

Vk²,

A³

2021

Int J Res Rev

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Objectives: To study the Clinical and Laboratory profile of children upto 12 years of age with Dengue fever and to study the predictors of Severe Dengue among these children. Methods: Design: Descriptive study over 1 year 9 months. Setting: SAT hospital, Thiruvananthapuram, a tertiary care center. Study Population: 204 children aged 1month to 12 years admitted with serologically confirmed dengue fever without any co-infections; consecutive sampling. Procedure: Relevant history, detailed physical examination and investigations were noted. Patients were classified for their severity based on DENGUE guidelines-WHO 2009. Children were followed up till discharge during hospital stay. Categorical values were expressed as proportions and quantitative variables in mean and standard deviation. Association between various study variables and severe dengue were statistically analysed. Results: Mild dengue was seen in 96 children(47.1%), moderate dengue in 78 children(38.2%) and severe dengue in 30 children(14.7%). Mean age of presentation was 6.4 years. Age distribution- infants were 4.4%, 38.7% were between 1 year and 5 years; 56.9% were between 6 and 12 years.51% of children were males. Common clinical presentation was fever (100%), vomiting(46.6%), abdominal pain(32.4%), lethargy(24.5%), myalgia(22%), headache(16.7%) and reduced appetite(15.7%). Mean fever duration was 5 days. Hypotension was noted in 13.2%, Tender hepatomegaly in 44%, signs of plasma leakage in 6%, hypoalbuminemia in 7.8%. Total number of death was 2(1%). Variables with significant association with severe dengue on univariate analysis were Lethargy (p-<0.001, OR- 11.6), reduced appetite (p- <0.001,OR- 17.14), mucosal bleed (p<0.001, OR- 15.45), Fever spike >39◦C (p- 0.001, OR- 4.3), tender hepatomegaly (p- 0.001, OR- 4.2), decreased urine output (p <0.001, OR- 23.04), hypoalbuminemia (p <0.001, OR-43.5), platelet count below 80,000 (p <0.001, OR-4.43), SGOT above 85 (p <0.001, OR-4.9). According to the maximum area under ROC curve, a cutoff of platelet count 80,000 had 75% sensitivity and 60% specificity for predicting severe dengue. Conclusion: Proportion of children developed severe dengue was 14.7%. Independent predictors of severe dengue after multiple logistic regression were Lethargy, Reduced appetite, Reduced urine output and Hypoalbuminemia. Keywords: severe dengue; urine output; shock; hypoalbuminemia.

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“…5 From 14 Knowledge of group vulnerable to DSS is essential for prevention efforts in the community as well as the rational implementation of dengue vaccines and antiviral drug. 18 The frequency of male affected in this study was more than female, similar to studies in India and Mexico, [19][20][21] but contrary to the studies in the following cities in Indonesia: Yogyakarta, Jakarta, and Bandung. [22][23][24] A study from 6 countries in Asia suggested that the males have a habit of being outdoors which provides a greater opportunity of getting dengue infection due to mosquito bites.…”

Section: Discussionsupporting

confidence: 75%

Epidemiology of Children with Severe Dengue Infection in Dr. Soetomo General Hospital

2020

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Introduction: Dengue infection is endemic to Indonesia and remains a public health problem. Severe dengue infection can cause rapid death, especially in children. Aim: To determine the epidemiology of children with severe dengue infection in Dr. Soetomo Hospital. A cross-sectional study was conducted at the pediatric ward of Dr. Soetomo Hospital. Data were derived from medical records of children aged ≤18 years which hospitalized with severe dengue from March to April 2019. Of 135 children admitted with DHF, obtained 48 samples with characteristics >5–12 years old (72.9%), male (58.3%), residence Surabaya (89.6%), elementary school (60.3%), referral (81.3%), hospitalized ≤5 days (66.7%), day of illness ≥4 days (89.6%), moderate malnutrition (35.4%), had severe plasma leakage consisting of DHF grade III (73%) and IV (27%). Two patients died (4.2%). No patient with congenital disease and malignancy. This study is not in line with the tendency of shifted dengue incidence to older age groups (>15 years old) in Indonesia. All patients had severe plasma leakage. No severe dengue patient with severe hemorrhage and organ impairment. Most patients were male, had moderate malnutrition, from referral, day of illness ≥4 days, hospitalized ≤5 days.

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Clinical profile of dengue and predictive severity variables among children at a secondary care hospital of Chilpancingo, Guerrero, Mexico: case series

Cited by 8 publications

References 15 publications

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Clinical and Laboratory Profile of Children with Dengue Fever and Predictors of Severe Dengue

Epidemiology of Children with Severe Dengue Infection in Dr. Soetomo General Hospital

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