Clinical, Radiographic, and Tumor Characteristics of Solitary Intra-Osseous Neurofibroma of Jaws- A Systematic Review

Sharma, Anka; Rai, Arpita; Kasat, Vikrant O

doi:10.1007/s12070-023-04058-9

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…In the present case, the lesion was successfully removed without any obvious complications, although a preoperative biopsy was not performed. Complete surgical excision of this lesion could mainly be attributed to the presence of a complete capsule, which indicates that setting the resection margin is easier compared with most solitary non-encapsulated neuro bromas [3,6,10,13,14]. Previous studies have reported that gross specimens of neuro broma tissue appear to have a doughy consistency with a whitish and shiny surface [4,19].…”

Section: Discussionmentioning

confidence: 87%

“…Only a few cases of solitary intraosseous neuro bromas of the oral cavity have been described in the literature, with those in the mandible being the most common location owing to the presence of a major nerve bundle, namely, the inferior alveolar nerve [6- 9,11,12]. This relative rarity of solitary intraosseous neuro bromas of the maxilla is exempli ed in a review by Sharma et al, wherein of the 22 cases in their series of solitary neuro bromas involving the jawbone over the last two decades, only four were neuro bromas of the maxilla [13]. Therefore, solitary intraosseous neuro bromas of the hard palate are extremely rare, as was observed in the present case.…”

Section: Discussionmentioning

confidence: 99%

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Solitary Intraosseous Neurofibroma of the Hard Palate: A Case Report and Literature Review

Guo,

Wu,

Liang

et al. 2024

Preprint

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Background Neurofibroma is a benign tumor of neuronal origin that can occur as a solitary tumor or as a component of the generalized syndrome of neurofibromatosis. Neurofibromas are primarily located in the subcutaneous soft tissues and commonly involve extra-oral sites. Solitary intraosseous neurofibromas of the oral cavity are infrequent, with occurrences in the maxilla being exceedingly rare. Case presentation: A 22-year-old male patient presented with an asymptomatic mass in the maxilla. Cone-beam computed tomography revealed a round, well-outlined, radiolucent lesion with expansive growth. The neoplasm with the complete capsule was completely removed and confirmed as a neurofibroma based on histopathological and immunohistochemical findings. The reported cases of solitary intraosseous neurofibromas located in the maxilla published in the English literature were compiled to assist in the diagnosis of solitary intraosseous neurofibromas of the maxilla. Four months after the surgery, there were no signs of tumor recurrence or malignant transformation. Conclusions This report emphasizes that rare neoplasms, such as solitary intraosseous neurofibromas, typically demonstrate nonspecific clinical and radiological features. Clinicians should consider solitary intraosseous neurofibromas as possible differential diagnoses and recognize the histopathological and immunohistochemical features to confirm the correct diagnosis. A longer follow-up period is required because of the potential for local recurrence and malignant transformation of these tumors.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Solitary Intraosseous Neurofibroma of the Hard Palate: A Case Report and Literature Review

Guo,

Wu,

Liang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In the present case, the lesion was successfully removed without any obvious complications. Complete surgical excision of this lesion could mainly be attributed to the presence of a complete capsule, which indicates that setting the resection margin is easier compared with most solitary non-encapsulated neurofibromas [ 3 – 6 , 10 , 13 , 14 ]. Previous studies have reported that gross specimens of neurofibroma tissue appear to have a doughy consistency with a whitish and shiny surface [ 4 , 19 ], which were observed in the current case.…”

Section: Discussionmentioning

confidence: 99%

“…Only a few cases of solitary intraosseous neurofibromas of the oral cavity have been described in the literature, with those in the mandible being the most common location owing to the presence of a major nerve bundle, namely, the inferior alveolar nerve [6][7][8][9][10][11][12]. This relative rarity of solitary intraosseous neurofibromas of the maxilla is exemplified in a review by Sharma et al, wherein of the 22 cases in their series of solitary neurofibromas involving the jawbone over the last two decades, only four were neurofibromas of the maxilla [13]. Therefore, solitary intraosseous neurofibromas of the hard palate are extremely rare, as was observed in the present case.…”

Section: Discussionmentioning

confidence: 99%

Solitary intraosseous neurofibroma of the oral cavity: rare localization in the maxilla

Guo,

Wu,

Liang

et al. 2024

BMC Oral Health

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Background Neurofibroma is a common benign tumor of neuronal origin that can occur as a solitary tumor or as a component of the generalized syndrome of neurofibromatosis. Neurofibromas are primarily located in the subcutaneous soft tissues and commonly involve extra-oral sites. Solitary intraosseous neurofibromas of the oral cavity are infrequent, with occurrences in the maxilla being exceedingly rare. Case presentation A 22-year-old male patient presented with an asymptomatic mass in the maxilla. Cone-beam computed tomography revealed a round, well-outlined, radiolucent lesion with expansive growth. The neoplasm with the complete capsule was completely removed and confirmed as a neurofibroma based on histopathological and immunohistochemical findings. The reported cases of solitary intraosseous neurofibromas located in the maxilla published in the English literature were compiled to assist in the diagnosis of solitary intraosseous neurofibromas of the maxilla. Nine months after the surgery, there were no signs of tumor recurrence or malignant transformation. Conclusions This report emphasizes that rare locations of neurofibromas, such as solitary intraosseous neurofibromas in the maxilla, typically demonstrate nonspecific clinical and radiological features. Clinicians should consider solitary intraosseous neurofibromas as possible differential diagnoses and recognize the histopathological and immunohistochemical features to confirm the correct diagnosis. A longer follow-up period is required because of the potential for local recurrence and malignant transformation of these tumors.

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Clinical, Radiographic, and Tumor Characteristics of Solitary Intra-Osseous Neurofibroma of Jaws- A Systematic Review

Cited by 2 publications

References 22 publications

Solitary Intraosseous Neurofibroma of the Hard Palate: A Case Report and Literature Review

Solitary Intraosseous Neurofibroma of the Hard Palate: A Case Report and Literature Review

Solitary intraosseous neurofibroma of the oral cavity: rare localization in the maxilla

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