Clinical, radiological and histological study of the failure of cervical interbody fusions with bone substitutes

Xie, Yubing; Chopin, D.; Hardouin, Pierre; Lu, Jianxi

doi:10.1007/s00586-005-0052-1

Cited by 30 publications

(21 citation statements)

References 28 publications

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“…Our results found no material-specific reasons for failure of bone substitutes as given in the literature [7,10,30,[35][36][37]. Probably the reasons for failure of substitutes have to be reduced to unspecific reasons like the age of the individual, tissue perfusion (due to sclerosis), and personal habits (smoking), or bony instability.…”

Section: Discussioncontrasting

confidence: 61%

Microvascular response to calcium phosphate bone substitutes: an intravital microscopy analysis

Roetman

Ring

Langer

et al. 2010

Langenbecks Arch Surg

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Section: Discussioncontrasting

confidence: 61%

Microvascular response to calcium phosphate bone substitutes: an intravital microscopy analysis

Roetman

Ring

Langer

et al. 2010

Langenbecks Arch Surg

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“…Being more degradable and bioresorbable in vivo than hydroxyapatite, b-TCP might be replaced faster by the new bone but weak in mechanical strength when load-bearing capacity is regarded. Xie et al [28] reported a failed case of anterior cervical interbody fusion with a stand-alone dense b-TCP block and suggested special design for the bioceramic to assure bone ingrowth and meet the mechanical requirements in cervical interbody fusion. In the current series, interbody cages were used to contain granulated b-TCP.…”

Section: Discussionmentioning

confidence: 99%

Anterior cervical fusion with interbody cage containing β-tricalcium phosphate augmented with plate fixation: a prospective randomized study with 2-year follow-up

Dai

Jiang

2008

Eur Spine J

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A variety of bone graft substitutes, interbody cages, and anterior plates have been used in cervical interbody fusion, but no controlled study was conducted on the clinical performance of b-tricalcium phosphate (b-TCP) and the effect of supplemented anterior plate fixation. The objective of this prospective, randomized clinical study was to evaluate the effectiveness of implanting interbody fusion cage containing b-TCP for the treatment of cervical radiculopathy and/or myelopathy, and the fusion rates and outcomes in patients with or without randomly assigned plate fixation. Sixty-two patients with cervical radiculopathy and/or myelopathy due to soft disc herniation or spondylosis were treated with one-or twolevel discectomy and fusion with interbody cages containing b-TCP. They were randomly assigned to receive supplemented anterior plate (n = 33) or not (n = 29). The patients were followed up for 2 years postoperatively. The radiological and clinical outcomes were assessed during a 2-year follow-up. The results showed that the fusion rate (75.0%) 3 months after surgery in patients treated without anterior cervical plating was significantly lower than that (97.9%) with plate fixation (P \ 0.05), but successful bone fusion was achieved in all patients of both groups at 6-month follow-up assessment. Patients treated without anterior plate fixation had 11 of 52 (19.2%) cage subsidence at last follow-up. No difference (P [ 0.05) was found regarding improvement in spinal curvature as well as neck and arm pain, and recovery rate of JOA score at all time intervals between the two groups. Based on the findings of this study, interbody fusion cage containing b-TCP following one-or two-level discectomy proved to be an effective treatment for cervical spondylotic radiculopathy and/or myelopathy. Supplemented anterior plate fixation can promote interbody fusion and prevent cage subsidence but do not improve the 2-year outcome when compared with those treated without anterior plate fixation.

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“…Surgibone contains 20-29% protein in the form of collagen which may be antigenic, despite manufacturer's claims. Xie et al recently conducted a histological study on a failed bovine union [109]. Despite apparent fusion on radiography, the authors could not attest to this histologically.…”

Section: Animal Allograft (Xenograft)mentioning

confidence: 99%

Bone graft substitutes in anterior cervical discectomy and fusion

2009

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Anterior cervical discectomy with fusion is a common surgical procedure for patients suffering pain and/ or neurological deficits and unresponsive to conservative management. For decades, autologous bone grafted from the iliac crest has been used as a substrate for cervical arthrodesis. However patient dissatisfaction with donor site morbidity has led to the search for alternative techniques. We present a literature review examining the progress of available grafting options as assessed in human clinical trials, considering allograft-based, synthetic, factor-and cell-based technologies.

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Clinical, radiological and histological study of the failure of cervical interbody fusions with bone substitutes

Cited by 30 publications

References 28 publications

Microvascular response to calcium phosphate bone substitutes: an intravital microscopy analysis

Microvascular response to calcium phosphate bone substitutes: an intravital microscopy analysis

Anterior cervical fusion with interbody cage containing β-tricalcium phosphate augmented with plate fixation: a prospective randomized study with 2-year follow-up

Bone graft substitutes in anterior cervical discectomy and fusion

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