2022
DOI: 10.1002/clc.23882
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Clinical recommendations to diagnose and monitor patients with transthyretin amyloid cardiomyopathy in Asia

Abstract: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a debilitating and lifethreatening condition with a heterogeneous clinical presentation. Recent guidelines from the United States and Europe have been published to guide clinical practice and to facilitate management conformity by covering current diagnostic and treatment strategies for patients with ATTR-CM. These guidelines highlight the importance of an early diagnosis to optimize therapeutic outcomes, specifying the use of tests and imaging techniques to al… Show more

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Cited by 5 publications
(10 citation statements)
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“…Expert consensus recommendations from the European Society of Cardiology (ESC) and the American Society of Nuclear Cardiology (ASNC) were consulted for the diagnostic pathway for ATTR-CM [2,17]. Additionally, other publications on various aspects of diagnosing ATTR-CM, such as a suspicion of the condition, the use of bone scintigraphy, imaging procedures, imaging parameters, and interpretation of the results, were also referred [3,[18][19][20][21][22][23][24][25].…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…Expert consensus recommendations from the European Society of Cardiology (ESC) and the American Society of Nuclear Cardiology (ASNC) were consulted for the diagnostic pathway for ATTR-CM [2,17]. Additionally, other publications on various aspects of diagnosing ATTR-CM, such as a suspicion of the condition, the use of bone scintigraphy, imaging procedures, imaging parameters, and interpretation of the results, were also referred [3,[18][19][20][21][22][23][24][25].…”
Section: Methodsmentioning
confidence: 99%
“…Cardiac manifestations of ATTR-CM include increased left ventricular wall thickness in the absence of hypertension or valvular heart disease, heart failure symptoms, diastolic dysfunction, atrial fibrillation, conduction system disease, and elevated cardiac biomarkers. Extra-cardiac manifestations include a history of bilateral carpal tunnel syndrome, spinal stenosis, hip or knee replacement, prior shoulder surgery, proteinuria, or peripheral/autonomic neuropathy [2,3,22,32]. The rationale for suggesting the diagnostic tests and criteria for ATTR-CM is based on the expert consensus, as well as the sensitivity and specificity of the tests.…”
Section: Clinical Suspicionmentioning
confidence: 99%
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“…Various scientific statements and consensus papers have also been developed to guide clinicians in the diagnosis, evaluation and management of CA. [1][2][3] Light at the End of the Tunnel Despite all the challenges, there is hope in improving care pathways to ensure early diagnosis and recognitions of CA in Malaysia. Building an amyloidosis network may be a good starting point, allowing for exchange of ideas and experiences between various centres to facilitate referrals for pivotal pathological and radiological services across the country.…”
Section: Clinical Perspectivementioning
confidence: 99%
“…In fact, clinical pathways in the initial evaluation and management of CA remain sparse in Malaysia, although an Asian consensus document does exist. 3 There is a complex interplay between various factors (Figure 1), and using two case examples, we highlight these barriers.…”
mentioning
confidence: 97%