Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: a pilot study

Peters, Mathilde C.; Tallman, J. A.; Braun, Thomas; Jacobson, Juliet

doi:10.1007/bf03262762

Cited by 36 publications

(26 citation statements)

References 12 publications

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“…The authors recognized that these data are preliminary and that double‐blind, randomized, longitudinal studies using more human subjects are required to conclude about the potential for using licorice lollipops for caries control in young children who are at risk for dental caries (Hu et al , 2011). Peters et al (2010) also carried out a pilot study using a lollipop made with a different licorice extract and showed that when used twice daily, it significantly reduces both number and relative percent of S. mutans in high‐risk preschool children. However, this study suffered from the lack of a true control group in which a placebo was used.…”

Section: Dental Caries and Licoricementioning

confidence: 99%

Licorice and its potential beneficial effects in common oro‐dental diseases

et al. 2011

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Licorice, the name given to the roots and stolons of Glycyrrhiza species, has been used since ancient times as a traditional herbal remedy. Licorice contains several classes of secondary metabolites with which numerous human health benefits have been associated. Recent research suggests that licorice and its bioactive ingredients such as glycyrrhizin, glabridin, licochalcone A, licoricidin, and licorisoflavan A possess potential beneficial effects in oral diseases. This paper reviews the effects of licorice and licorice constituents on both the oral microbial pathogens and the host immune response involved in common ora-dental diseases (dental caries, periodontitis, candidiasis, and recurrent aphthous ulcers). It also summarizes results of clinical trials that investigated the potential beneficial effects of licorice and its constituents for preventing/treating oro-dental diseases.

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Section: Dental Caries and Licoricementioning

confidence: 99%

Licorice and its potential beneficial effects in common oro‐dental diseases

et al. 2011

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“…Jain et al (15) have showed antimicrobial and cariostatic efficacy of liquorice extracts and recommend that liquorice can be used as a preventive regimen in pediatric dental practice. Hu et al (20) and Peters et al (1) have demonstrated that licorice containing lollipop led to reduction in salivary SM in their studies.…”

Section: Introductionmentioning

confidence: 94%

“…Dental caries is a multifactorial, infectious and most common disease, caused by a specific group of cariogenic bacteria (1,2). World Health Organization estimated that 5 billion people of the world's 6.5 billion population are affected by dental caries (3).…”

Section: Introductionmentioning

confidence: 99%

“…Glycyrrhiza glabra, known as Licorice root, is one such medicinal plant that has been used since ancient times to relieve coughs, sore throats, gastric inflammation as a traditional herbal remedy (15). It has been used as a sweetener in food and drug industry and Food and Drug Administration listed licorice in generally regarded as safe (1).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Efficacy of Chlorhexidine and Licorice Mouthwashes in Children

Öznurhan¹,

Buldur²,

Cartı³

et al. 2019

meandros

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Amaç: Bu in vivo çalışmanın amacı, çocuklarda tükürük Streptococcus mutans (SM) düzeylerini azaltmaya yönelik basit bir bitkisel çürük önleme protokolünün etkinliğini değerlendirmektir. Gereç ve Yöntemler: Yapılan bu çalışmada Klorheksidin (CHX), meyan kökü ve serum fizyolojik kullanılmıştır. Toplam 90 hasta, her bir grup için 30 kişi olacak şekilde rastgele 3 gruba ayrıldı. Gargara öncesi, gargaradan 5 dk sonra ve gargaradan 1 saat sonrasında tükürük örnekleri toplanmıştır. Değerlendirmeler gargara sonrası 5 dk (T1), 1 saat sonra (T2) ve aradaki farklılıkları tespit amacıyla 5-60 dk (T3) olarak hesaplanmıştır. Ekimi yapılan örneklerin enkübasyon süresi sonunda plaklar değerlendirmeye alınarak üreyen kolonilerin colony forming Unit/mL (CFU mL-1) olarak sayımları yapılmıştır. CFU değerlerindeki azalmalar istatistiksel olarak analiz edildi. Elde edilen verilerin değerlendirilmesinde Kruskall-Wallis, Mann-Whitney U and Bonferroni düzeltmeli Friedman, Wilcoxon işaret ve testleri ile yapıldı ve yanılma düzeyi 0,05 olarak alındı. Bulgular: CHX, T1 ve T2 zamanları içerisinde istatistiksel olarak anlamlı düşüşler gösterirken (p<0,05), T3 grubunda CHX ve meyan kökü grubunda istatistiksel olarak anlamlı bir farklılık görülmedi (p>0,05). Sonuç: Meyan kökü dental işlemlerde kullanılabilecek yararlı bir ajan olabilir ve meyan kökü oranının, içerisindeki glisirizik asit yüzdesinin ve tedavinin süresi ile ilgili daha ileri çalışmaların yapılması gerekmektedir. Objective:The aim of this in vivo study is to evaluate the effectiveness of a simple herbal caries-prevention protocol for reducing salivary Streptococcus mutans levels in children. MaterialsandMethods:A total of 90 individuals were recruited randomly divided into three groups (n=30). Mouthwashes including chlorhexidine (CHX), licorice and saline were used as tested antimicrobial agents, and saliva samples were collected before rinsing, at the end of 5 min (T1) and 60 min (T2) following rinsing, and the differences were calculated within 5-60 min (T3). Plaques were evaluated following incubation, and counts of the growing colonies were performed in colony forming units (CFU)/mL. Decreases in CFU were calculated in ratio for statistical analysis. Data were analyzed with Kruskal-Wallis, Mann-Whitney U, Friedman and Wilcoxon signed rank tests by Bonferroni correction, using a 0.05 of significance level. Results: CHX caused significantly different decreases for T1 and T2 (p<0.05), but, there were no significant differences between CHX and licorice for T3 (p>0.05). Conclusion: Licorice might be a useful agent for dental procedures and further studies are needed to learn more about the dose of licorice, the ratio of glycyrrhizin and the duration of dental therapy. Anah tarKe li me ler

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“…The studies involved in the lollipop development demonstrated in adults its safety and effectiveness in reducing bacterial count and percentage over a 10-day period of twice-daily administration 35 . Twice-daily use of herbal liquorice lollipop significantly reduced the number and relative percentage of S. mutans in high-risk children during a 3-week intervention 36 . The results of these studies indicate that further randomised controlled trials are needed to determine the efficacy of the antibacterial properties as well as the impact of bacterial reduction in dental caries prevention.…”

Section: Herbal Liquoricementioning

confidence: 99%

Developing pathways for oral care in elders: evidence‐based interventions for dental caries prevention in dentate elders

Ghezzi

2014

Gerodontology

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Background Dental caries is becoming an ever‐growing challenge as the number of elders maintaining their teeth increases. There is a need for low‐cost, effective preventive interventions to retain natural teeth for elders. Objective The purpose of this article is to evaluate evidence based interventions for dentate elders, specifically the adjunct therapies of fluoride, chlorhexidine, xylitol, casein phosphopeptide‐amorphous calcium phosphate, ozone, and herbal liquorice. Results Fluoride interventions have demonstrated prevention and remineralization of dental caries in elders. Systematic reviews of the literature are unable to establish definitive conclusions regarding the effectiveness of other adjunct therapies in dental caries prevention. Conclusions Further research with elders requires improved study design with well designed multi‐center trials. Considerations for new strategies for research of the effectiveness of therapies to reduce dental caries include the development and evaluation of combinations of therapeutic interventions and dental caries management by risk assessment.

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Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: a pilot study

Abstract: A potential for simple effective caries-prevention for high-risk children has been demonstrated. Encouraging results warrant randomised clinical trials (RCT) of liquorice root in herbal lollipops or alternative modes of delivery.

Cited by 36 publications

References 12 publications

Licorice and its potential beneficial effects in common oro‐dental diseases

Licorice and its potential beneficial effects in common oro‐dental diseases

Antimicrobial Efficacy of Chlorhexidine and Licorice Mouthwashes in Children

Developing pathways for oral care in elders: evidence‐based interventions for dental caries prevention in dentate elders

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