Clinical relationship between Hashimoto's thyroiditis and papillary thyroid cancer

Ahn, Dongbin; Heo, Sung Jae; Park, Ji Hyun; Kim, Jae Hyug; Sohn, Jin Ho; Park, Ji Young; Park, Sun-Kyun; Park, Junesik

doi:10.3109/0284186x.2011.602109

Cited by 125 publications

(111 citation statements)

References 18 publications

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“…Although it is not statistically significant, our study showed that, the TNM staging of PTC patients in HT group had a higher proportion of stage I than the PTC patients in non-HT group. These results were compatible with the literatüre and these results can be suggestive that the tumor's biological behavior is better in the case of HT or its due to the close follow-up of HT patients for thyroid disorders (3,6,9,14).…”

Section: Discussionsupporting

confidence: 80%

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Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Kutlutürk¹,

Ünal²,

Çetin³

2017

J Turgut Ozal Med Cent

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Aim: A positive correlation between Hashimoto's thyroiditis (HT) and papillary thyroid cancer (PTC) is determinated in studies based on histopathological examination of the thyroidectomy materials, but this correlation is not determinated in studies based on Fine Niddle Aspiration Biopsy (FNAB). In this study, the histopathologic results of bilateral total thyroidectomy (TT) specimens were studied for outcomes of PTC association with HT and its relationship with clinical and pathological prognostic factors. Material and Methods: Demographic data, thyroidectomy indications and pathology results of 568 patients with performed TT between April 2009 March 2016 were collected. PTC identified patients, were evaluated in terms of HT association. In these patients, the prognostic factors were evaluated according to coexistence of HT. Results: The average age of the patients was 48.9 years and M / F ratio was 1: 3.5. HT was detected in 36 patients and PTCin 121 patients by histopathological examinations. PTC incidence in HT group was higher than non-HT group. (p = 0.025). HT incidence in PTC group was higher than non-PTC group (p = 0.025).When compared in terms of demographic and prognostic data of PTC patiens,no statistically significant difference was detected between PTC with and without HT groups. Conclusion: PTC detection rate in patients with HT, who has indication for thyroidectomy is higher than non-HT patients. HT patients (especially female sex), should be followed closely, in terms of the development of malignant nodules.

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Section: Discussionsupporting

confidence: 80%

“…In addition, many studies reported that PTC patients with HT is younger (6,8). This mismatch, may be due to the small number of PTC patients with HT in our study group.…”

Section: Discussionmentioning

confidence: 42%

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Kutlutürk¹,

Ünal²,

Çetin³

2017

J Turgut Ozal Med Cent

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“…The literature also describes other types of malignant lesions such as medullary carcinomas and even anaplastic thyroid cancer [21]. Generally, the percentages of PTC exceed those of FTC and medullary carcinoma [20][21][22].…”

Section: Prace Oryginalnementioning

confidence: 99%

Clinical, ultrasonographical and histopathological aspects in Hashimoto’s thyroiditis associated with malignant and benign thyroid nodules

Zosin¹,

Balaş²

2013

Endokrynologia Polska

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Intriduction: The reported prevalence of chronic autoimmune thyroiditis associated with differentiated thyroid cancer (DTC) is heterogeneous. The aim of this study was to evaluate some epidemiological, clinical, sonographical and histological features of operated thyroid nodules with background diffuse autoimmune thyroiditis. Material and methods:The study included 411 cases with Hashimoto's thyroiditis (HT), of which 118 presented thyroid nodular disease (TND). Thyroidectomy was performed in 76 cases. Of these patients, 24 presented histologically confirmed DTC and 52 benign lesions. DTC types were as follows: papillary thyroid cancer (PTC) (n = 6), follicular variant of PTC (FVPTC) (n = 6), papillary microcarcinomas (n = 8), follicular thyroid carcinoma (n = 1) and the mixed form (classic PTC and FVPTC) (n = 3). The benign nodules were dominated by: follicular adenoma (48%), and colloid goitre (40.3%). Results:The sonographic features with predictive risk for malignancy in cases with HT associated with TND were represented by: solid composition, hypoechogenicity and microcalcifications. The characters of margins, the nodular shape and the type of vascularity do not seem to be as useful for identification of malignant nodules in HT. Fine needle-aspiration biopsy (FNAB) showed in DTC cases different cytological smears: malignant (ten), indeterminate (eight), benign (two), and non-diagnostic (four). In the group of benign nodules, the indeterminate smears represented also a significant percentage (n = 12). Conclusions: The incidence of TND associated with HT was 28.7%. Among 76 operated cases, 31.5% presented DTC. The accuracy of FNAB in the preoperative diagnosis showed higher sensitivity (90.0%) and specificity (61.5%) compared to sonographic criteria. StreszczenieWstęp: Podawane w literaturze dane na temat rozpowszechnienia przewlekłego autoimmunologicznego zapalenia tarczycy związanego ze zróżnicowanym rakiem tarczycy (DTC, differentiated thyroid cancer) cechuje duża rozpiętość. Celem badania była ocena wybranych cech epidemiologicznych, klinicznych, ultrasonograficznych i histopatologicznych operowanych guzków tarczycy u pacjentów z rozlanym autoimmunologicznym zapaleniem tarczycy. Materiał i metody: Do badania włączono 411 przypadków choroby Hashimoto (HT, Hashimoto thyroiditis), z czego 118 pacjentów zgłosiło się do lekarza z powodu choroby guzkowej tarczycy (TND, thyroid nodular disease). Tyroidektomię wykonano u 76 pacjentów, przy czym u 24 pacjentów badanie histopatologiczne wykazało DTC, a u pozostałych 52 -zmiany łagodne. Postacie DTC były następujące: rak brodawkowaty tarczycy (PTC, papillary thyroid cancer) (n = 6), wariant pęcherzykowy PTC (FVPTC, follicular variant of papillary thyroid cancer) (n = 6), mikroraki brodawkowate (n = 8), rak pęcherzykowy tarczycy (n = 1) i postać mieszana (klasyczny PTC i FVPTC) (n = 3). Większość guzków łagodnych stanowiły gruczolaki pęcherzykowe (48%) i wole koloidalne (40,3%). Wyniki: Cechy ultrasonograficzne związane z ryzykiem rozpoznania nowotworu złośl...

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“…Several analyses of surgical resection specimens have shown that PTC is frequently accompanied by HT. Interestingly, PTC with HT is associated with a lower rate of neck lymph node metastasis and has a better prognosis than PTC without thyroiditis in spite of increased incidence correlation [1][2][3][4][5][6][7][8][9][10]. In contrast, other studies conducted by fine-needle aspiration biopsy specimens and ultrasonographic findings have found no correlation between the incidences of these two diseases, with researchers insisting that HT does not increase the risk of thyroid…”

mentioning

confidence: 72%

Genomic evidence of reactive oxygen species elevation in papillary thyroid carcinoma with Hashimoto thyroiditis

Park

Sung

et al. 2015

Endocr J

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Abstract. Elevated levels of reactive oxygen species (ROS) have been proposed as a risk factor for the development of papillary thyroid carcinoma (PTC) in patients with Hashimoto thyroiditis (HT). However, it has yet to be proven that the total levels of ROS are sufficiently increased to contribute to carcinogenesis. We hypothesized that if the ROS levels were increased in HT, ROS-related genes would also be differently expressed in PTC with HT. To find differentially expressed genes (DEGs) we analyzed data from the Cancer Genomic Atlas, gene expression data from RNA sequencing: 33 from normal thyroid tissue, 232 from PTC without HT, and 60 from PTC with HT. We prepared 402 ROS-related genes from three gene sets by genomic database searching. We also analyzed a public microarray data to validate our results. Thirtythree ROS related genes were up-regulated in PTC with HT, whereas there were only nine genes in PTC without HT (Chisquare p-value < 0.001). Mean log 2 fold changes of up-regulated genes was 0.562 in HT group and 0.252 in PTC without HT group (t-test p-value = 0.001). In microarray data analysis, 12 of 32 ROS-related genes showed the same differential expression pattern with statistical significance. In gene ontology analysis, up-regulated ROS-related genes were related with ROS metabolism and apoptosis. Immune function-related and carcinogenesis-related gene sets were enriched only in HT group in Gene Set Enrichment Analysis. Our results suggested that ROS levels may be increased in PTC with HT. Increased levels of ROS may contribute to PTC development in patients with HT.Key words: Reactive oxygen species, Thyroid cancer, Hashimoto thyroiditis, Gene expression, Bioinformatics illary thyroid carcinoma (PTC) has been extensively studied, but the precise relationship between these two diseases is still being debated. Several analyses of surgical resection specimens have shown that PTC is frequently accompanied by HT. Interestingly, PTC with HT is associated with a lower rate of neck lymph node metastasis and has a better prognosis than PTC without thyroiditis in spite of increased incidence correlation [1][2][3][4][5][6][7][8][9][10]. In contrast, other studies conducted by fine-needle aspiration biopsy specimens and ultrasonographic findings have found no correlation between the incidences of these two diseases, with researchers insisting that HT does not increase the risk of thyroid Original

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Clinical relationship between Hashimoto's thyroiditis and papillary thyroid cancer

Abstract: HT was definitely associated with PTC as was chronic inflammation with cancer in other locations. Interestingly, however, the coexistence of HT in PTC cases introduced favourable clinical outcomes compared with those of PTC without HT.

Cited by 125 publications

References 18 publications

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Clinical, ultrasonographical and histopathological aspects in Hashimoto’s thyroiditis associated with malignant and benign thyroid nodules

Genomic evidence of reactive oxygen species elevation in papillary thyroid carcinoma with Hashimoto thyroiditis

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