Clinical Relevance of Postprandial Lipaemia

Kolovou, Genovefa; Anagnostopoulou, Katherine K.; Daskalopoulou, Stella S.; Mikhailidis, Dimitri P.; Cokkinos, Dennis V.

doi:10.2174/0929867054546609

Cited by 115 publications

(113 citation statements)

References 176 publications

(231 reference statements)

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“…coronary heart disease, explaining why some individuals develop atherosclerotic disease despite normal fasting lipid values 2) . TG-rich lipoproteins are involved in atherosclerosis and thrombosis, and TG, remnant-like particle (RLP)-C and RLP-TG increase after a fat load and could contribute to atherothrombosis.…”

mentioning

confidence: 99%

Acute Effects of Shortly Pre- Versus Postprandial Aerobic Exercise on Postprandial Lipoprotein Metabolism in Healthy but Sedentary Young Women

Hashimoto

Ootani

Hayashi

et al. 2011

JAT

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mentioning

confidence: 99%

Acute Effects of Shortly Pre- Versus Postprandial Aerobic Exercise on Postprandial Lipoprotein Metabolism in Healthy but Sedentary Young Women

Hashimoto

Ootani

Hayashi

et al. 2011

JAT

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“…[7][8][9] Indeed, elevated intestinally derived remnant lipoproteins have been associated with increased cardiovascular disease. 10 It is therefore of considerable clinical interest to better understand the mechanism(s) leading to TRL accumulation so that strategies can be formulated to reduce their plasma levels.…”

mentioning

confidence: 99%

Hyperinsulinemia Is Associated With Increased Production Rate of Intestinal Apolipoprotein B-48–Containing Lipoproteins in Humans

Duez

Lamarche

Uffelman

et al. 2006

ATVB

159

109

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Objectives-Whereas postprandial hyperlipidemia is a well-described feature of insulin-resistant states and type 2 diabetes, no previous studies have examined intestinal lipoprotein production rates (PRs) in relation to hyperinsulinemia or insulin resistance in humans. Methods and Results-Apolipoprotein B-48 (apoB-48)-containing lipoprotein metabolism was examined in the steady-state fed condition with a 15-hour primed constant infusion of [D3]-L-leucine in 14 nondiabetic men with a broad range of body mass index (BMI) and insulin sensitivity. To examine the relationship between indices of insulin resistance and intestinal lipoprotein PR data were analyzed in 2 ways: by correlation and by comparing apoB-48 PRs in those whose fasting plasma insulin concentrations were above or below the median for the 14 subjects studied (60 pmol/L). ApoB-48 PR was significantly higher in hyperinsulinemic, insulin-resistant subjects (1.73Ϯ0.39 versus 0.88Ϯ0.13 mg/kg per day; PϽ0.05) and correlated with fasting plasma insulin concentrations (rϭ0.558; Pϭ0.038), despite great heterogeneity in apoB-48 kinetic parameters, particularly among the obese subjects. There was no significant difference in clearance of apoB-48 between the 2 groups, nor was there a significant correlation between apoB-48 fractional clearance rate and fasting insulin or homeostasis model assessment-insulin resistance. Conclusions-These are the first human data to conclusively demonstrate that intestinal apoB-48 -containing triglyceride-rich lipoprotein PR is increased in hyperinsulinemic, insulin-resistant humans. Intestinal lipoprotein particle overproduction is a newly described feature of insulin resistance in humans.

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“…Also, it is the remnant lipoproteins associated with elevated triglycerides and not the triglycerides, per se, that are considered atherogenic [15,16]. The presence of an enlarged waist with elevated triglyceride levels could identify individuals unable to clear and store excess triglycerides from over-nutrition and, therefore, identify individuals who are more likely to be chronically exposed to elevated remnant lipoproteins than individuals without the phenotype [1].…”

Section: Research Articlementioning

confidence: 99%

Hypertriglyceridemic-Waist Phenotype is a Useful Global Assessment Tool for Predicting Acute Myocardial Infarction

Egeland¹,

Igland²,

Nygård³

et al. 2015

J Cardiovasc Dis Diagn

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Research ArticleOpen Access strongly with post-prandial remnant lipoproteins, and that non-fasting triglycerides are superior to fasting triglycerides in characterizing the usual post-prandial state and its' associated risks [13,14]. Also, it is the remnant lipoproteins associated with elevated triglycerides and not the triglycerides, per se, that are considered atherogenic [15,16]. The presence of an enlarged waist with elevated triglyceride levels could identify individuals unable to clear and store excess triglycerides from over-nutrition and, therefore, identify individuals who are more likely to be chronically exposed to elevated remnant lipoproteins than individuals without the phenotype [1].Given the strong association of the hypertriglyceridemic-waist phenotype with insulin resistance and that elevated non-fasting triglycerides associate with greater exposures to atherogenic remnant lipoproteins, we evaluated, prospectively, the risk of incident acute IntroductionThe presence of hypertriglyceridemia with an elevated waist circumference, referred to as the hypertriglyceridemic-waist phenotype, is considered a proxy indicator of visceral fat which is now recognized to have greater metabolic consequences than that attributed to subcutaneous fat alone [1]. The phenotype has also been proposed to be a simpler alternative to the metabolic syndrome, and there has, therefore, been growing research interest in exploring the utility of the hypertriglyceridemic-waist phenotype as a predictor of cardiometabolic risk [2]. Numerous studies have identified the phenotype as being a strong associate and determinant of insulin resistance and diabetes in cross-sectional and prospective studies [3][4][5][6][7]. While a few prospective studies have evaluated the association between the phenotype and cardiovascular disease (CVD), the results of these studies are highly variable [8][9][10][11][12]. Thus, the usefulness of the phenotype as an independent predictor of CVD beyond classical CVD risk factors is not yet established.In addition, data suggest that non-fasting triglycerides correlate AbstractBackground: There has been growing research interest in exploring the utility of the hypertriglyceridemicwaist phenotype as a predictor of cardio-metabolic risk. To date, prospective studies evaluating the phenotype as a predictor of cardiovascular disease have provided variable results. Objectives:To evaluate the usefulness of the hypertriglyceridemic-waist phenotype as an independent predictor of acute myocardial infarction beyond classical cardiovascular disease risk factors in a homogeneous Norwegian population. Methods:Norwegian health survey (Cohort Norway) participants (n=116,111), free of heart disease in 1994-2003, were followed through 2009 by record linkages to The Cause of Death Registry and hospital discharge diagnoses through the Cardiovascular disease in Norway project. Cox proportional hazards analyses adjusted for conventional risk factors.Results: During a mean follow-up of 11.5 yrs (SD=2.8), 3,624 participants...

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Clinical Relevance of Postprandial Lipaemia

Cited by 115 publications

References 176 publications

Acute Effects of Shortly Pre- Versus Postprandial Aerobic Exercise on Postprandial Lipoprotein Metabolism in Healthy but Sedentary Young Women

Acute Effects of Shortly Pre- Versus Postprandial Aerobic Exercise on Postprandial Lipoprotein Metabolism in Healthy but Sedentary Young Women

Hyperinsulinemia Is Associated With Increased Production Rate of Intestinal Apolipoprotein B-48–Containing Lipoproteins in Humans

Hypertriglyceridemic-Waist Phenotype is a Useful Global Assessment Tool for Predicting Acute Myocardial Infarction

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