2015
DOI: 10.3889/oamjms.2015.017
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Clinical Relevance of Transforming Growth Factor-β1, Interleukin-6 and Haptoglobin for Prediction of Obesity Complications in Prepubertal Egyptian Children

Abstract: BACKGROUND:The rate of obesity is increasing throughout the world. Obesity in adults’ research is characterized by chronic inflammation, associated with type 2 Diabetes and cardiovascular risk. The degree to which these changes occur in childhood obesity is not fully defined.AIM:This study was designed to explore the relation between circulating levels of pro-inflammatory cytokines, and obesity.PATIENTS AND METHODS:This cross sectional case control study was carried out in 50 randomly selected pre-pubertal ove… Show more

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Cited by 11 publications
(5 citation statements)
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“…suPAR is considered a biomarker of both inflammation and immune activation since it is released from several cell types in response to inflammatory stimulation [ 24 ], and higher levels can be associated with a risk of cardiovascular disease (CVD), type II diabetes, cancer, and premature mortality, independent of CRP levels [ 25 ]. Higher levels of the three inflammatory biomarkers-CRP, haptoglobin, and suPAR-have been found in obese subjects, particularly in children and adolescents [ 17 , 26 , 27 ]. Gut microbiota is connected to energy homeostasis and inflammation and can be considered as a factor in the pathophysiology of obesity [ 28 ].…”
Section: Introductionmentioning
confidence: 99%
“…suPAR is considered a biomarker of both inflammation and immune activation since it is released from several cell types in response to inflammatory stimulation [ 24 ], and higher levels can be associated with a risk of cardiovascular disease (CVD), type II diabetes, cancer, and premature mortality, independent of CRP levels [ 25 ]. Higher levels of the three inflammatory biomarkers-CRP, haptoglobin, and suPAR-have been found in obese subjects, particularly in children and adolescents [ 17 , 26 , 27 ]. Gut microbiota is connected to energy homeostasis and inflammation and can be considered as a factor in the pathophysiology of obesity [ 28 ].…”
Section: Introductionmentioning
confidence: 99%
“…In a case control study by Alameey et al obese or overweight group of children was compared with healthy, non-obese children. The finding showed that the level of TGF-β1 were significantly positively correlated with the body weight, BMI (kg/m 2 ) and BMI z-score of obese/overweight cases, respectively (P < 0.001, in all) [ 12 ]. Other studies in human subjects showed that secretion of TGF-β1 by adipose tissue increases in obese individuals [ 13 ].…”
Section: Discussionmentioning
confidence: 99%
“…Lastly, I'm not alone-in my view-that obesity is a state of chronic inflammation, which is characterized by high levels inflammatory biomarkers like interleukin-6, and transforming growth factor-beta (TGF-β) 24 . TGF-β is a polypeptide-cytokine of multicellular activities 25,26 , formed by respiratory epithelium and stimulates fibroblasts-multiplication which may cause significant lung-fibrosis 27 .…”
Section: Discussionmentioning
confidence: 99%