Clinical research activity in periodontal medicine: a systematic mapping of trial registers

Monsarrat, Paul; Blaizot, Alessandra; Kémoun, Philippe; Ravaud, Philippe; Nabet, Cathy; Sixou, Michel; Vergnes, Jean-Noël

doi:10.1111/jcpe.12534

Cited by 148 publications

(117 citation statements)

References 76 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…It has been proposed that periodontal disease, as a chronic infectious inflammatory disease, may be a risk factor for various systemic diseases, including dementia, although the scientific evidence is not conclusive. Dementia is considered a severe public health problem, with an estimated prevalence of more than 37 million cases worldwide that is expected to increase .…”

Section: Introductionmentioning

confidence: 99%

Systemic inflammatory impact of periodontitis on cognitive impairment

et al. 2019

View full text Add to dashboard Cite

Objectives The role in dementia of systemic inflammation derived from periodontal disease is not fully elucidated. The objective of our study was to examine the impact of inflammation on the relationship between periodontitis and cognitive impairment. Methods We have designed a case (n = 171) and control (n = 131) study to determine the periodontal health status, grade of cognitive impairment/dementia and systemic inflammation level, the last being measured by analysis of 29 inflammatory biomarkers using multiplex techniques. Results At the time of sampling, 11 of the 29 inflammatory biomarkers were associated with cognitive impairment in patients with more severe periodontitis. However, the inflammatory response to severe periodontitis was more reduced (lower biomarker concentrations) in cases (with cognitive impairment or dementia) than in (cognitively healthy) controls, an unexpected finding. Conclusions Based on these results, we cannot confirm that systemic inflammation derived from periodontal disease plays a relevant role in the aetiology of cognitive impairment.

show abstract

Section: Introductionmentioning

confidence: 99%

Systemic inflammatory impact of periodontitis on cognitive impairment

et al. 2019

View full text Add to dashboard Cite

show abstract

“…A recent systematic review indicates that nearly 2% of terms in MeSH from the WHO International Clinical Trials Registry Platform representing 57 systemic conditions have been related to periodontal disease, and most of them are NCDs . Indeed, in the past 2 decades, many studies have explored the association of different systemic conditions with periodontal disease and the relevant implications of clinical intervention.…”

Section: Introductionmentioning

confidence: 99%

Periodontal disease increases the risk for onset of systemic comorbidities in dental hospital attendees: An 18‐year retrospective cohort study

Zhao

Zhen

Pelekos

et al. 2018

Journal of Periodontology

View full text Add to dashboard Cite

Background Periodontal disease closely links to various systemic diseases. This l8‐year retrospective cohort study investigated whether poor periodontal condition may increase the risk for onset of systemic comorbidities. Methods A total of 488 individual dental folders from 17 400 dental hospital attendees registered from 1996 to 1998 were randomly selected, and these participants were free of diabetes, cardiovascular disease, chronic obstructive pulmonary disease, cancer, stroke, cognitive impairment, hypertension, and dyslipidemia in the Clinical Management System. The records of periodontal examination and orthopantomogram on the first registration were obtained, and full‐mouth bone level (BL) was measured. Onsets of the eight comorbidities concerned above until 2016 were retrieved from the system. Results The participants with worse periodontal status on their first registration had significantly higher numbers of the eight comorbidities/mortality during the 18‐year follow‐ups than their counterparts (P < 0.05). BL presented as bone loss/age was independently correlated to the comorbidity profiles in two multivariate models (0 to 1 versus ≥2; 0 to 2 versus ≥3) after adjusting for age and sex (odds ratio [OR] = 1.87; OR = 2.18, P < 0.05), highlighting that the individuals with more bone resorption exhibited a greater number of the comorbidities as compared with their counterparts. Moreover, those with onsets of more comorbidities showed worse periodontal conditions according to four parameters employed (community periodontal index, BL, bone loss/age and number of remaining teeth) (P < 0.05). Conclusions Within the limitations of this 18‐year retrospective cohort study, our findings provide the first evidence that periodontal disease experience to some extent reflects the host susceptibility to onset of common systemic comorbidities. Further studies with larger sample sizes and appropriate adjustment of critical confounders are highly warranted to substantiate the current observation.

show abstract

“…In the previous issue of the Journal of Clinical Periodontology, a thought‐provoking paper lists the clinical research in progress in the field of periodontal medicine (Monsarrat et al. ). Interestingly and intriguingly, the paper of Monsarrat et al.…”

mentioning

confidence: 99%

“…Interestingly and intriguingly, the paper of Monsarrat et al. () takes another approach by compiling a list of the possible links of periodontitis with other systemic conditions. Instead of using existing and published research, as was gathered in the joint EFP/AAP workshop, Monsarrat and co‐workers used modern bio‐ and medical informatics tools to tabulate from existing worldwide trial registers all submitted clinical research proposals on the topic of periodontal medicine.…”

mentioning

confidence: 99%