Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis

Jacquet, Pierre; Sugarbaker, Paul H.

doi:10.1007/978-1-4613-1247-5_23

Cited by 1,495 publications

(1,262 citation statements)

References 36 publications

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“…The volume and extent of the tumor deposits were prospectively recorded using the PCI. 7 This assessment combines lesion size (0 to 3) with tumor distribution (abdominopelvic region 0 to13) to quantify the extent of disease as a numerical score (PCI-0 to 39) (Fig. 1).…”

Section: Standardized Data Formmentioning

confidence: 99%

“…7 Sites and volumes of the residual disease after CRS were also prospectively recorded using the completeness of cytoreduction (CC) Score. 7 A CC-0 indicated no visible evidence of disease, CC-1 indicated residual tumors 2.5 mm in diameter, CC-2 indicated residual tumors between 2.5 mm and 2.5 cm in diameter, and CC-3 indicated residual tumors >2.5 cm in diameter or a confluence of tumor nodules present at any site. Standardized clinical data on consecutive patients from each of the 8 institutions were entered into a central database.…”

Section: Standardized Data Formmentioning

confidence: 99%

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A novel tumor‐node‐metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi‐institutional database*

Yan

Deraco²,

Élias

et al. 2010

Cancer

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135

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A novel digital active homodyne demodulation scheme to eliminate the signal fading in interferometric fiber‐optic sensors is proposed. The error signal is obtained by the square‐wave phase modulation and then the digital correlation detection technique is applied to demodulate the low‐frequency environmental phase drift and generate the offset phase, which is then fed back the integrated optical phase modulator to lock the interferometer in quadrature. The high‐frequency signal phase can be read out and recovered from the photodetector output with the interferometer in quadrature. The simulation and experimental results verify the feasibility of the proposed scheme, which obviates the feedback integrator saturation and the system resetting problem encountered in the conventional active homodyne detection schemes. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:20–23, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25640

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Section: Standardized Data Formmentioning

confidence: 99%

Section: Standardized Data Formmentioning

confidence: 99%

A novel tumor‐node‐metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi‐institutional database*

Yan

Deraco²,

Élias

et al. 2010

Cancer

Self Cite

135

View full text Add to dashboard Cite

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“…The peritoneal cancer index is a quantitative assessment of cancer distribution of tumor throughout the abdomen and pelvis (14). Two components are involved in its calculation.…”

Section: Peritoneal Cancer Indexmentioning

confidence: 99%

“…The completeness of cytoreduction score is an assessment of the volume of disease that remains after the surgery (14). The site containing the largest amount of residual disease following cytoreductive surgery must be recorded.…”

Section: Completeness Of Cytoreduction Scorementioning

confidence: 99%

Histopathologic Analysis in 46 Patients with Pseudomyxoma Peritonei Syndrome: Failure versus Success with a Second-Look Operation

et al. 2001

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Pseudomyxoma peritonei syndrome is a disease characterized by mucinous ascites and mucinous tumor disseminated on peritoneal surfaces; the disease almost always originates from a perforated appendiceal epithelial tumor. Histopathologic assessment of aggressive versus noninvasive character of the mucinous tumor has been shown to have an impact on survival in patients treated with cytoreductive surgery and intraperitoneal chemotherapy. Out of a database of 312 patients having a complete cytoreduction for pseudomyxoma peritonei syndrome, 46 patients (24 male and 22 female) had at least one second-look surgery. Before this review, all 46 of these patients were clinically uniformly categorized with a diagnosis of pseudomyxoma peritonei. Using the criteria described by Ronnett and colleagues, all specimens from the multiple surgical procedures performed on these patients were reviewed and reclassified as disseminated peritoneal adenomucinosis (adenomucinosis), adenomucinosis/mucinous adenocarcinoma (hybrid), or mucinous adenocarcinoma. The review was performed in a blinded fashion by a single pathologist (HY). To facilitate a critical evaluation of these histopathologic assessments, the patients were separated into two groups: (1) 19 patients who had a second-look surgery that was unsuccessful in that they went on to die of their disease or in that they currently have disease progression and a limited survival and (2) 27 patients who had a successful second look and currently continue disease free with a minimum 3-year follow-up period. As a result of this review, 11 of 19 patients with an unsuccessful second look and originally designated pseudomyxoma peritonei were reclassified as hybrid-type malignancy (four patients) or mucinous adenocarcinoma (seven patients). Only two patients were reclassified in the successful second-look group (P ‫؍‬ .0005). Transitions from a less aggressive to a more invasive histology from one cytoreduction to the next occurred on 13 occasions in patients whose second-look surgery failed and in one patient with a successful second-look surgery (P < .0001). Seven patients retained a histologic classification of disseminated peritoneal adenomucinosis but went on to die of an aggressive disease process. Clinical assessments suggested that failure of second-look surgery for pseudomyxoma peritonei was associated with a biologically more aggressive disease. Unsuccessful second-look surgery for patients with a clinical diagnosis of pseudomyxoma peritonei tumor was often related to an inaccurate initial histologic classification of appendiceal mucinous tumor. Also, a transition from less to more aggressive histology was frequently seen in patients dying of this disease. Assessment of tumor histology can predict the outcome if a uniform surgical treatment is used in patients with peritoneal dissemination of mucinous epithelial tumors of the appendix.

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“…Quantitative prognostic indicators have been defined to measure the outcomes of CRS and HIPEC and these should be used in selecting patients for the procedure. [18] These indicators are histopathology, imaging findings, peritoneal cancer index (PCI) and the completeness of cytoreduction score (CCR). [18,19] Apart from the general health and fitness for the procedure, these indicators should be taken into consideration before taking up a patient for surgery.…”

Section: Patient Selection For Crs and Hipecmentioning

confidence: 99%

Cytoreductive Surgery and Peritonectomy Procedures

Mehta

Bhatt

Gléhen

2016

Indian J Surg Oncol

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Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has become widely accepted as an effective method of treating peritoneal metastases (PM) from various cancers. CRS performed with the goal of removing all the macroscopic disease and comprises of peritonectomy procedures and visceral resections. CRS is a technically challenging surgery that requires a considerable amount of skill and appropriate patient selection. This article is a review of the techniques and current recommendations for performing CRS.

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Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis

Cited by 1,495 publications

References 36 publications

A novel tumor‐node‐metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi‐institutional database*

A novel tumor‐node‐metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi‐institutional database*

Histopathologic Analysis in 46 Patients with Pseudomyxoma Peritonei Syndrome: Failure versus Success with a Second-Look Operation

Cytoreductive Surgery and Peritonectomy Procedures

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