Clinical Research Trends in Respiratory Diseases Related to Particulate Matter

유, 이란; 김, 진후; 양, 원경; 김, 승형; 박, 양춘

doi:10.22246/jikm.2019.40.3.443

J Int Korean Med

2019

DOI: 10.22246/jikm.2019.40.3.443

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Clinical Research Trends in Respiratory Diseases Related to Particulate Matter

이란 유¹,

진후 김²,

원경 양³

et al.

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Cited by 3 publications

References 30 publications

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Review on the Effects of Herbal Medicine on Respiratory Diseases in <italic>In Vivo</italic> Particulate Matter Models

Woo¹,

Lee²,

Park³

2023

J Int Korean Med

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Objective: This study was conducted to review the effects of herbal medicine on respiratory diseases induced by the treatment of particulate matter in in vivo animal models.Methods: Literature searches were performed in seven databases (Pubmed, Embase, Cochrane Library, KISS, KTKP, OASIS, and ScienceON). After the searched studies were screened based on the inclusion/exclusion criteria, the publication date, origin, used animals, induction of particulate matter models, herbal medicine used for intervention, study design, outcome measure, and results of studies were analyzed.Results: Among a total of 972 studies primarily searched, 34 studies were finally included in our study. Of this number, 29 studies induced animal models by using only particulate matter, and 5 studies induced animal models with respiratory diseases, such as asthma and chronic obstructive pulmonary disease, by using particulate matter and other materials. In the selected studies, the treatments of herbal medicine in particulate matter models suppressed oxidative stress and inflammation in lung tissue, bronchoalveolar lavage fluid, and blood as well as lung injury in histological analysis.Conclusion: The results of this study suggest that herbal medicine is effective in treating respiratory diseases induced by particulate matter. These results are also expected to be useful data for designing further studies. However, more systematically designed in vivo studies related to particulate matter are needed.

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Review on the Effects of Herbal Medicine on Respiratory Diseases in <italic>In Vivo</italic> Particulate Matter Models

Woo¹,

Lee²,

Park³

2023

J Int Korean Med

Self Cite

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Artemisia gmelinii Attenuates Lung Inflammation by Suppressing the NF-κB/MAPK Pathway

et al. 2022

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Cigarette smoke (CS) is the main cause of chronic obstructive pulmonary disease (COPD), and continuous CS exposure causes lung inflammation and deterioration. To investigate the protective effects of Artemisia gmelinii against lung inflammation in this study, cigarette smoke extract (CSE)/lipopolysaccharide (LPS)-treated alveolar macrophages (AMs) and mice stimulated with CSE/porcine pancreas elastase (PPE) were used. Artemisia gmelinii ethanol extract (AGE) was effective in decreasing the levels of cytokines, chemokine, inducible nitric oxide synthase, and cyclooxygenase-2 by inhibiting mitogen-activated protein (MAP) kinases/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway in AMs. Additionally, oral administration of AGE suppressed inflammatory cells’ infiltration and secretion of inflammatory cytokines, chemokines, matrix metallopeptidase 9, and neutrophil extracellular traps in bronchoalveolar lavage fluid from the COPD model. Moreover, the obstruction of small airways, the destruction of the lung parenchyma, and expression of IL-6, TNF-α, IL-1β, and MIP-2 were suppressed by inhibiting NF-κB activation in the lung tissues of the AGE group. These effects are associated with scopolin, chlorogenic acid, hyperoside, 3,4-di-Ο-caffeoylquinic acid, 3,5-di-Ο-caffeoylquinic acid, and 4,5-di-Ο-caffeoylquinic acid, which are the main components of AGE. These data demonstrate the mitigation effect of AGE on lung inflammation via inhibition of MAPK and NF-κB pathways, suggesting that AGE may be instrumental in improving respiratory and lung health.

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The Status and Influencing Factors of Respiratory System Diseases in Korean Farmers with Disease

gyeong¹,

Soo²,

Choi³

et al. 2020

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Clinical Research Trends in Respiratory Diseases Related to Particulate Matter

Cited by 3 publications

References 30 publications

Review on the Effects of Herbal Medicine on Respiratory Diseases in <italic>In Vivo</italic> Particulate Matter Models

Review on the Effects of Herbal Medicine on Respiratory Diseases in <italic>In Vivo</italic> Particulate Matter Models

Artemisia gmelinii Attenuates Lung Inflammation by Suppressing the NF-κB/MAPK Pathway

The Status and Influencing Factors of Respiratory System Diseases in Korean Farmers with Disease

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