Clinical resolution of glycogenic hepatopathy following improved glycemic control

Hudacko, Rachel; Manoukian, Aram V.; Schneider, Stephen H.; Fyfe, Billie

doi:10.1016/j.jdiacomp.2007.11.004

Cited by 50 publications

(46 citation statements)

References 2 publications

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“…GH tends to occur in patients with poorly controlled T1D, especially in children and adolescents (Table 1) [1,2,4,[6][7][8][9][10][11][12]. GH has also been reported in patients with poorly controlled type 2 diabetes (T2D) treated with insulin therapy [17], as well as in a T2D patient who injected 180 units of insulin glargine as suicide Schiff (PAS) staining (Fig.…”

Section: Discussionmentioning

confidence: 99%

A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRI

et al. 2012

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Section: Discussionmentioning

confidence: 99%

A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRI

et al. 2012

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“…Some diabetic patients, with poor metabolic control, may develop reversible hepatomegaly and high serum transaminase concentrations, which is rarely reported in the literature (1). Hepatic enlargement in diabetes is usually the result of either glycogenosis or non-alcoholic steatohepatitis (NASH) (3).…”

Section: Discussionmentioning

confidence: 99%

“…Glycogenic hepatopathy (GH) is a rare and underecognized condition observed in poorly controlled diabetes (1). It is a diagnosis with unique pathologic features due to hepatocyte glycogen overload that is reversible with good glycemic control (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Glycogenic hepatopathy in young adults: a case series

Silva¹,

Marques²,

Cardoso³

et al. 2016

Rev Esp Enferm Dig

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Glycogenic hepatopathy is a rare and underecognized complication in long-standing poorly controlled type 1 diabetes mellitus patients. This is a distinct entity from other causes of hepatomegaly and elevated liver enzymes in diabetics, such as nonalcoholic fatty liver disease. Glycogenic hepatopathy is characterized by the combination of poorly controlled diabetes, acute liver injury with marked elevation in serum aminotransferases, and the characteristic histological features on liver biopsy. It is important to distinguish this entity as it has the potential for resolution following improved glycemic control.In this report, we describe four cases of adult patients presenting elevated serum transaminases and hepatomegaly with a history of poorly controlled type I diabetes mellitus. One of the patients had also elevated amylase and lipase in the serum, without clinical or imagiologic evidence of acute pancreatitis. Liver biopsy was performed in all patients and revealed glycogenic hepatopathy. Clinician's awareness of glycogenic hepatopathy should prevent diagnostic delay or misdiagnosis and will provide better insight and management for this condition.

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“…4,5,11,12 The disappearance of clinical hepatomegaly and resolution of symptoms after initiation of insulin can range from weeks to months.…”

Section: Treatment and Prognosismentioning

confidence: 99%

A 21-Year-Old Woman with Hepatomegaly

Barry

Zaki²,

Munro³

et al. 2015

CJGIM

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SummaryWe report the case of a 21-year old woman with uncontrolled diabetes mellitus type 1 presenting with tender hepatomegaly and mildy elevated liver enzymes, with negative investigations for common causes. She was diagnosed by liver biopsy with glycogenic hepatopathy, an uncommon and likely under-recognized complication of poor glycemic control. The disease is typically reversible after weeks to months of appropriate insulin therapy and is unlikely to lead to permanent liver disease. Our patient was treated with a new insulin regimen and analgesics and discharged home. Unfortunately, on follow-up imaging in our patient 10 months later, her hepatomegaly persists. Her glycemic control remains unchanged and she has since been admitted to hospital twice for episodes of diabetic ketoacidosis. RésuméIl s'agit du cas d'une femme de 21 ans présentant un diabète de type 1 non équilibré accompagné d'une hépatomégalie douloureuse et d'une légère augmentation du taux des enzymes du foie, et pour qui les investigations du côté des causes courantes s'avèrent négatives. Une biopsie du foie mena à un diagnostic d'hépathopathie glycogénique, une complication peu courante et souvent mal identifiée qui résulte d'un mauvais contrôle de la glycémie. La maladie est habituellement réversible en quelques semaines ou mois d'insulinothérapie et mène rarement à des atteintes hépatiques permanentes. La patiente a été traitée à l'aide d'une nouvelle insulinothérapie et des analgésiques et a pu retourner à la maison. Malheureusement, lors de l'imagerie médicale de suivi effectuée sur la patiente dix mois plus tard, l'hépatomégalie est toujours présente. La glycémie s'avère inchangée et depuis ce suivi la patiente a dû être hospitalisée deux fois pour des épisodes d'acidocétose diabétique.

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Clinical resolution of glycogenic hepatopathy following improved glycemic control

Cited by 50 publications

References 2 publications

A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRI

A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRI

Glycogenic hepatopathy in young adults: a case series

A 21-Year-Old Woman with Hepatomegaly

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